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Suppressed Th17 levels correlated with upregulated expression of negative regulatory genes, PIAS3, SHP2, and SOCS3 in CD4 T cells during acute SIV infection.
Data indicate that PIAS3 (protein inhibitor of activated STAT3) interaction modulates EKLF (erythroid Kruppel-like factor (显示 KLF1 ELISA试剂盒)) activity in a promoter-dependent and SUMO-independent manner.
PIAS3 suppresses acute graft-versus-host disease by modulating effector T and B cell subsets through inhibition of STAT3 (显示 STAT3 ELISA试剂盒) activation.
These data indicate that tachypacing decreased ATBF1 (显示 ZFHX3 ELISA试剂盒), leading to enhanced STAT3 (显示 STAT3 ELISA试剂盒) DNA-binding activity due to the reduced formation of a binary complex of ATBF1 (显示 ZFHX3 ELISA试剂盒) and PIAS3.
MRL/lpr (显示 FAS ELISA试剂盒) mice have significantly increased expressions of STAT3 (显示 STAT3 ELISA试剂盒) mRNA and protein and decreased expression of mRNA PIAS3 in the kidneys compared with BALB/C mice.
L97A, R99N and R99Q mutations of the PINIT domain (PIAS3(85-272) ) were found to abrogate binding to STAT3 (显示 STAT3 ELISA试剂盒), suggesting that these residues were part of a potential binding surface.
Our results indicate that Pias3-dependent SUMOylation of photoreceptor-specific transcription factors is a common mechanism that controls both rod and cone photoreceptor subtype specification, regulating distinct molecular targets in the two cell types
there is an interaction between Zimp7 (显示 ZMIZ2 ELISA试剂盒) and PIAS (显示 PIAS1 ELISA试剂盒) proteins with higher preference for PIAS3, in androgen receptor (显示 AR ELISA试剂盒)-mediated transcription
results indicate a potential role of PIAS3 as transcriptional modulator of TIF2 (显示 NCOA2 ELISA试剂盒)-mediated signalling
role in inducing SUMO-1 (显示 SUMO1 ELISA试剂盒) modification and transcriptional repression of IRF-1 (显示 IRF1 ELISA试剂盒)
identified a novel conserved domain of 180 residues in PIAS (显示 PIAS1 ELISA试剂盒) proteins and showed that its 'PINIT' motif as well as other conserved motifs (in the SAP (显示 APCS ELISA试剂盒) box and in the RING domain) are independently involved in nuclear retention of PIAS3L
PAI-1 (显示 SERPINE1 ELISA试剂盒) interacted with PIAS3 to regulate Stat3 (显示 STAT3 ELISA试剂盒)-dependent gene expression and miR (显示 MLXIP ELISA试剂盒)-34a was transcriptionally suppressed by Stat3 (显示 STAT3 ELISA试剂盒) to form a positive regulatory loop through Stat3 (显示 STAT3 ELISA试剂盒) signaling in non-small cell lung cancer cells.
Levels of PIAS3 are significantly lower, in contrast with phosphorylation of STAT3 (显示 STAT3 ELISA试剂盒), in women with endometriosis compared to women without endometriosis.
TRIM8 (显示 TRIM8 ELISA试剂盒) activates STAT3 (显示 STAT3 ELISA试剂盒) by suppressing the expression of PIAS3, an inhibitor of STAT3 (显示 STAT3 ELISA试剂盒), most likely through E3-mediated ubiquitination and proteasomal degradation.
Low PIAS3 expression is associated with breast cancer organoid invasiveness.
SHP2 (显示 PTPN11 ELISA试剂盒), SOCS3 (显示 SOCS3 ELISA试剂盒) and PIAS3 levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 downregulation is more reversely correlated with STAT3 (显示 STAT3 ELISA试剂盒) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (显示 STAT3 ELISA试剂盒) downregulation and decreased incidence of STAT3 (显示 STAT3 ELISA试剂盒) nuclear translocation, PIAS3 is upregulated, the SHP2 (显示 PTPN11 ELISA试剂盒) level remains unchanged and SOCS3 (显示 SOCS3 ELISA试剂盒) is downregulated.
The results revealed that although the expression levels of SOCS1 (显示 SOCS1 ELISA试剂盒), SOCS3 (显示 SOCS3 ELISA试剂盒) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 (显示 STAT3 ELISA试剂盒) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.
3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 (显示 STAT3 ELISA试剂盒) signaling through the induction of PIAS3.
PIAS3 may serve as a biomarker for predicting hormone therapy stratification, although it is limited to those breast cancer patients receiving hormone therapy.
Taken together, these results suggest that PIAS3 functions as a positive regulator of HIF-1alpha (显示 HIF1A ELISA试剂盒)-mediated transcription by increasing its protein stability.
PIAS3 suppression may be protective against joint destruction in rheumatoid arthritis by regulating synoviocyte migration, invasion, and activation.
This gene encodes a member of the PIAS
protein inhibitor of activated STAT, 3
, E3 SUMO-protein ligase PIAS3-like
, e3 SUMO-protein ligase PIAS3-like
, E3 SUMO-protein ligase PIAS3
, protein inhibitor of activated STAT protein 3
, zinc finger, MIZ-type containing 5
, potassium channel regulatory protein KChAP
, potassium channel-associated protein