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抗Mouse (Murine) PIAS3 抗体:
抗Human PIAS3 抗体:
抗Rat (Rattus) PIAS3 抗体:
Human Polyclonal PIAS3 Primary Antibody for IHC (p), WB - ABIN1882115
Nojiri, Joh, Miura, Sakata, Nomura, Nakao, Sobue, Ohara, Asai, Ito: ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. in Biochemical and biophysical research communications 2004
Show all 7 Pubmed References
Human Polyclonal PIAS3 Primary Antibody for IHC (p), WB - ABIN1882116
Long, Wang, Matsuura, He, Liu: Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 7 Pubmed References
Suppressed Th17 levels correlated with upregulated expression of negative regulatory genes, PIAS3, SHP2, and SOCS3 in CD4 T cells during acute SIV infection.
Data indicate that PIAS3 (protein inhibitor of activated STAT3) interaction modulates EKLF (erythroid Kruppel-like factor (显示 KLF1 抗体)) activity in a promoter-dependent and SUMO-independent manner.
PIAS3 suppresses acute graft-versus-host disease by modulating effector T and B cell subsets through inhibition of STAT3 (显示 STAT3 抗体) activation.
These data indicate that tachypacing decreased ATBF1 (显示 ZFHX3 抗体), leading to enhanced STAT3 (显示 STAT3 抗体) DNA-binding activity due to the reduced formation of a binary complex of ATBF1 (显示 ZFHX3 抗体) and PIAS3.
MRL/lpr (显示 FAS 抗体) mice have significantly increased expressions of STAT3 (显示 STAT3 抗体) mRNA and protein and decreased expression of mRNA PIAS3 in the kidneys compared with BALB/C mice.
L97A, R99N and R99Q mutations of the PINIT domain (PIAS3(85-272) ) were found to abrogate binding to STAT3 (显示 STAT3 抗体), suggesting that these residues were part of a potential binding surface.
Our results indicate that Pias3-dependent SUMOylation of photoreceptor-specific transcription factors is a common mechanism that controls both rod and cone photoreceptor subtype specification, regulating distinct molecular targets in the two cell types
there is an interaction between Zimp7 (显示 ZMIZ2 抗体) and PIAS (显示 PIAS1 抗体) proteins with higher preference for PIAS3, in androgen receptor (显示 AR 抗体)-mediated transcription
results indicate a potential role of PIAS3 as transcriptional modulator of TIF2 (显示 NCOA2 抗体)-mediated signalling
role in inducing SUMO-1 (显示 SUMO1 抗体) modification and transcriptional repression of IRF-1 (显示 IRF1 抗体)
identified a novel conserved domain of 180 residues in PIAS (显示 PIAS1 抗体) proteins and showed that its 'PINIT' motif as well as other conserved motifs (in the SAP (显示 APCS 抗体) box and in the RING domain) are independently involved in nuclear retention of PIAS3L
PAI-1 (显示 SERPINE1 抗体) interacted with PIAS3 to regulate Stat3 (显示 STAT3 抗体)-dependent gene expression and miR (显示 MLXIP 抗体)-34a was transcriptionally suppressed by Stat3 (显示 STAT3 抗体) to form a positive regulatory loop through Stat3 (显示 STAT3 抗体) signaling in non-small cell lung cancer cells.
Levels of PIAS3 are significantly lower, in contrast with phosphorylation of STAT3 (显示 STAT3 抗体), in women with endometriosis compared to women without endometriosis.
TRIM8 (显示 TRIM8 抗体) activates STAT3 (显示 STAT3 抗体) by suppressing the expression of PIAS3, an inhibitor of STAT3 (显示 STAT3 抗体), most likely through E3-mediated ubiquitination and proteasomal degradation.
Low PIAS3 expression is associated with breast cancer organoid invasiveness.
SHP2 (显示 PTPN11 抗体), SOCS3 (显示 SOCS3 抗体) and PIAS3 levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 downregulation is more reversely correlated with STAT3 (显示 STAT3 抗体) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (显示 STAT3 抗体) downregulation and decreased incidence of STAT3 (显示 STAT3 抗体) nuclear translocation, PIAS3 is upregulated, the SHP2 (显示 PTPN11 抗体) level remains unchanged and SOCS3 (显示 SOCS3 抗体) is downregulated.
The results revealed that although the expression levels of SOCS1 (显示 SOCS1 抗体), SOCS3 (显示 SOCS3 抗体) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 (显示 STAT3 抗体) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.
3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 (显示 STAT3 抗体) signaling through the induction of PIAS3.
PIAS3 may serve as a biomarker for predicting hormone therapy stratification, although it is limited to those breast cancer patients receiving hormone therapy.
Taken together, these results suggest that PIAS3 functions as a positive regulator of HIF-1alpha (显示 HIF1A 抗体)-mediated transcription by increasing its protein stability.
PIAS3 suppression may be protective against joint destruction in rheumatoid arthritis by regulating synoviocyte migration, invasion, and activation.
This gene encodes a member of the PIAS
protein inhibitor of activated STAT, 3
, E3 SUMO-protein ligase PIAS3-like
, e3 SUMO-protein ligase PIAS3-like
, E3 SUMO-protein ligase PIAS3
, protein inhibitor of activated STAT protein 3
, zinc finger, MIZ-type containing 5
, potassium channel regulatory protein KChAP
, potassium channel-associated protein