Oncostatin M 蛋白 (OSM)产品概述

Full name:
Oncostatin M 蛋白 (OSM)
在www.antibodies-online.cn可供75 Oncostatin M (OSM) 蛋白的20不同的供货商。 再加上,我们可以发Oncostatin M 抗体 (208)Oncostatin M 试剂盒 (63)和数多这个蛋白质的别的产品。 总共357 Oncostatin M产品已列进来了。
OncoM, OSM
列出全部蛋白 基因 基因ID UniProt
OSM 5008 P13725
OSM 18413 P53347
OSM 289747 Q65Z15


按照种类Oncostatin M 蛋白 (OSM)


引用最多的Oncostatin M 蛋白

  1. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN2666535 : Beigel, Friedrich, Probst, Sotlar, Göke, Diegelmann, Brand: Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. in PLoS ONE 2014 (PubMed)
    Show all 7 references for 2666535

  2. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN2667567 : Chen, Benveniste: Oncostatin M: a pleiotropic cytokine in the central nervous system. in Cytokine & growth factor reviews 2004 (PubMed)
    Show all 5 references for 2667567

  3. Human Oncostatin M Protein expressed in HEK-293 Cells - ABIN2181568 : Tanaka, Miyajima: Oncostatin M, a multifunctional cytokine. in Reviews of physiology, biochemistry and pharmacology 2003 (PubMed)
    Show all 3 references for 2181568

  4. Human Oncostatin M Protein expressed in HEK293 - ABIN2039658 : Yin, Chain: Suppression of lymphokine production in anti-minor histocompatibility antigen responses. in Cytokine 1991 (PubMed)
    Show all 3 references for 2039658

  5. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN413690 : Sen, Che, Rajamani, Zerboni, Sung, Ptacek, Arvin: Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 references for 413690

  6. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN667495 : Nair, DeVico, Nakamura, Copeland, Chen, Patel, ONeil, Oroszlan, Gallo, Sarngadharan: Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 2 references for 667495

更多Oncostatin M互动伙伴

Human Oncostatin M (OSM) interaction partners

  1. OSM-induced plasticity was Signal Transducer and Activator of Transcription 3 (STAT3 (显示 STAT3 蛋白))-dependent, and also required a novel intersection with transforming growth factor-beta (TGF-beta)/SMAD (显示 SMAD1 蛋白) signaling. Removal of OSM or inhibition of STAT3 (显示 STAT3 蛋白) or SMAD3 (显示 SMAD3 蛋白) resulted in a marked reversion to a non-invasive, epithelial phenotype.

  2. Neutrophils are a major source of OSM-producing cells in patients with chronic rhinosinusitis and severe asthma.

  3. OSM and OSMR are highly expres (显示 TNF 蛋白)sed in inflammatory bowel disease intestinal mucosa compared to control mucosa. OSM promotes inflammatory behavior in human intestinal stroma.

  4. Study showed that in atrial fibrillation (AF) with thrombus, the atrial tissue infiltration of M1 macrophages increased significantly; the OSM expression was also found to increase simultaneously; downstream tissue factor (显示 F3 蛋白) (TF) increased and tissue factor (显示 F3 蛋白) pathway inhibitors (TFPI (显示 TFPI 蛋白))decreased, leading to an imbalance between TF and TFPI (显示 TFPI 蛋白) eventually. OSM might be related to thrombosis in patients with AF mediated by TF and TFPI (显示 TFPI 蛋白)

  5. a novel STAT3 (显示 STAT3 蛋白)/SMAD3 (显示 SMAD3 蛋白)-signaling axis is required for OSM-mediated senescence.

  6. This result demonstrates that HPV16 oncoproteins upregulate oncostatin M and play an important role to promote oral squamous cell carcinoma development

  7. The identification of the OSM inflammatory pathway as an important mediator of epithelial mesenchymal transition in triple-negative breast cancer (TNBC) may provide a novel potential opportunity to improve therapeutic strategies.

  8. Nucleolin stabilizes oncostatin-M mRNA by binding to a GC-rich element in its 3'UTR.

  9. Oncostatin M and interleukin-31 (显示 IL31 蛋白): Cytokines, receptors, signal transduction and physiology.

  10. Oncostatin M can regulate airway smooth muscle responses alone or in synergy with IL-17A (显示 IL17A 蛋白).

Mouse (Murine) Oncostatin M (OSM) interaction partners

  1. OSM mitigated the proliferation of Th17 cells and decreased the expression of IL-17 (显示 IL17A 蛋白) and IL-21 (显示 IL21 蛋白); it promoted the activation of suppressor of cytokine signaling 3 (SOCS3 (显示 SOCS3 蛋白)), STAT3 (显示 STAT3 蛋白), and STAT5 (显示 STAT5A 蛋白); observations suggest that OSM can inhibit Th17 differentiation by reciprocally controlling SOCS3 (显示 SOCS3 蛋白), STAT3 (显示 STAT3 蛋白), and STAT5 (显示 STAT5A 蛋白)

  2. In an animal model of anti-TNF (显示 TNF 蛋白)-resistant intestinal inflammation, genetic deletion or pharmacological blockade of OSM significantly attenuates colitis.

  3. these results support the proinflammatory role of OSM when it is overexpressed in the skin. However, OSM expression was not required in the murine model of psoriasis induced by topical application of imiquimod, as demonstrated by the inflammatory phenotype of OSM-deficient mice or wild-type mice treated with anti-OSM antibodies.

  4. OSM (mOSM) signals mainly via an OSM receptor (OSMR (显示 OSMR PLURAL_@42467@))-gp130 (显示 LRPPRC PLURAL_@42467@) heterodimer and binds with only very low affinity to mLIFR.

  5. Loss of Oncostatin M Signaling in Adipocytes Induces Insulin (显示 INS 蛋白) Resistance and Adipose Tissue Inflammation in Vivo.

  6. mechanism of OSM-induced cardiomyocyte dedifferentiation is associated with B-Raf (显示 SNRPE 蛋白)/Mek (显示 MDK 蛋白)/Erk (显示 EPHB2 蛋白) signaling pathway through the OSM receptor Obeta

  7. Oncostatin M and interleukin-31 (显示 IL31 蛋白): Cytokines, receptors, signal transduction and physiology.

  8. OSM plays multiple critical roles in the maintenance and development of the hematopoietic microenvironment in the bone marrow at a steady state as well as after injury.

  9. OSM treatment preserved cardiac function, inhibited apoptosis and fibrosis, and stimulated angiogenesis via upregulating VEGF (显示 VEGFA 蛋白) and bFGF (显示 FGF2 蛋白) in infarct border zone of ischemic myocardium, indicating that OSM could be a novel therapeutic target for MI.

  10. The mechanism of Oncostatin M on cardiac ischemia/reperfusion injury is partly mediated by the Notch3 (显示 NOTCH3 蛋白)/Akt (显示 AKT1 蛋白) pathway.

Cow (Bovine) Oncostatin M (OSM) interaction partners

  1. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.

蛋白简介Oncostatin M (OSM)


Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.

Alternative names and synonyms associated with Oncostatin M (OSM)

  • oncostatin M (OSM)
  • oncostatin M (Osm)
  • oncostatin M-like (LOC100342491)
  • oncostatin-M-like (LOC100152038)
  • OncoM 蛋白
  • OSM 蛋白

Protein level used designations for Oncostatin M 蛋白 (OSM)

oncostatin M , oncostatin-M

736338 Pan troglodytes
5008 Homo sapiens
18413 Mus musculus
289747 Rattus norvegicus
319086 Bos taurus
100724699 Cavia porcellus
611921 Canis lupus familiaris
101122466 Ovis aries
100342491 Oryctolagus cuniculus
100152038 Sus scrofa
Oncostatin M 蛋白 (OSM) 精选生产商