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Rat (Rattus) JAK2 ELISA Kit for Sandwich ELISA - ABIN435372
Li, Ma, Jiang, Bai, Yan, Liu, Pan, Liu, Chen: Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus. in Scientific reports 2017
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (显示 IFNG ELISA试剂盒) signal.
Testing for JAK2 mutations is now included in the World Health Organization (WHO) criteria for the diagnosis of MPN (显示 PRSS27 ELISA试剂盒), and in 2011 the oral JAK2 kinase inhibitor ruxolitinib became the first Food and Drug Administration (FDA (显示 FDA ELISA试剂盒))-approved drug for the treatment of myelofibrosis.
In our study, there was no genotypic or phenotypic association between the JAK2 rs10758669 variant and UC. Only the (C) allele was identified to increase the risk of a more severe disease progression.
C-CALR (显示 CALR ELISA试剂盒) in response to Ca2 (显示 CA2 ELISA试剂盒)+ undergoes conformational changes that trigger its function to export GR from the nucleus, resetting the stress response of normal erythroid cells. Impairment of this function in JAK2V617F-positive erythroid cells maintains EPO-R (显示 EPOR ELISA试剂盒) signaling in proliferation mode, contributing to erythrocytosis in PV.
BRM (显示 SMARCA2 ELISA试剂盒) could activate JAK2/STAT3 (显示 STAT3 ELISA试剂盒) pathway to promote pancreatic cancer growth and chemoresistance.
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
Multiple myeloma cells over express JAK1 (显示 JAK1 ELISA试剂盒)/2 and suggest combined chemotherapy with ruxolitinib, bortezomib and lenalidomide to inhibit JAK (显示 JAK3 ELISA试剂盒)/STAT (显示 STAT1 ELISA试剂盒) pathway.
Molecular interactions of EphA4 (显示 EPHA4 ELISA试剂盒), growth hormone receptor (显示 GHR ELISA试剂盒), Jak2, and STAT5B (显示 STAT5B ELISA试剂盒) have been described.
Peritoneal membrane dysfunction in long-term peritoneal dialysis patients may result from IL-6 (显示 IL6 ELISA试剂盒) promotion of epithelial-to-mesenchymal transition of human peritoneal mesothelial cells possibly through the JAK2/STAT3 (显示 STAT3 ELISA试剂盒) signaling pathway.
Mutation inactivating JAK2 gene is associated with Breast Cancer Metastasis.
mechanical load upregulates expression of Runx2 (显示 RUNX2 ELISA试剂盒) gene via potentiation of PC1 (显示 PCSK1 ELISA试剂盒)-JAK2/STAT3 (显示 STAT3 ELISA试剂盒) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (显示 CBL ELISA试剂盒)(mut (显示 MUT ELISA试剂盒)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (显示 EZH2 ELISA试剂盒) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (显示 EZH2 ELISA试剂盒) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (显示 EZH2 ELISA试剂盒)
findings demonstrate that clinically relevant doses of the JAK1 (显示 JAK1 ELISA试剂盒)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
JAK2 has a role in hepatocarcinogenesis through regulating critical inflammatory pathways
Data show that CUZD1 (显示 CUZD1 ELISA试剂盒) interacts with a complex containing JAK1 (显示 JAK1 ELISA试剂盒)/JAK2 and STAT5 (显示 STAT5A ELISA试剂盒), downstream transducers of prolactin (显示 PRL ELISA试剂盒) signaling in the mammary gland.
The results showed that AG490 inhibited (p)-JAK2 and RANKL (显示 TNFSF11 ELISA试剂盒) expression.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (显示 JAK3 ELISA试剂盒)-STAT (显示 STAT1 ELISA试剂盒)-AKT (显示 AKT1 ELISA试剂盒) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (显示 STAT5A ELISA试剂盒) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (显示 STAT5A ELISA试剂盒) and mTOR (显示 FRAP1 ELISA试剂盒) signaling pathways.
SNPs in JAK2 and STAT5B (显示 STAT5B ELISA试剂盒) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase