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Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-cell function, particularly of CD8 (显示 CD8A ELISA试剂盒)(+) T cells, and, may be linked with immune failure and loss of viral containment.
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2 (显示 IL2 ELISA试剂盒)- and IL-15 (显示 IL15 ELISA试剂盒)-activated T-cells has been reported.
systematic scoping review highlights the many potential uses of soluble interleukin-2 (显示 IL2 ELISA试剂盒) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
analysis of the contribution of IL2Rgamma to the dynamic formation of IL2 (显示 IL2 ELISA试剂盒)-IL2R (显示 IL2RA ELISA试剂盒) complexes
A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency (显示 PRKDC ELISA试剂盒) with an atypical phenotype
novel missense mutation in Japanese patient results in atypical X-linked severe combined immunodeficiency (显示 PRKDC ELISA试剂盒) with the presence of T cells and NK cells and revertant somatic mosaicism
reversion of mutation in common lymphoid progenitor results in mild phenotype of SCID (显示 PRKDC ELISA试剂盒)
High IL2RG expression is associated with Sezary syndrome.
Identification of a gammaC splice isoform revealed expression of soluble gammaC proteins (sgammaC). sgammaC directly interacted with surface IL-2Rbeta (显示 IL2RB ELISA试剂盒) to suppress IL-2 (显示 IL2 ELISA试剂盒) signaling and to promote pro-inflammatory Th17 cell differentiation. [review]
Study show the detection of IL2RG mutations in 2 families with X-SCID (显示 PRKDC ELISA试剂盒) and identified 2 novel mutations, confirming the X-SCID (显示 PRKDC ELISA试剂盒) pedigrees.
Interleukin 2 receptor subunit gamma mutation is associated with X-linked severe combined immunodeficiency (显示 PRKDC ELISA试剂盒).
Suggest that soluble common gamma chain may be one of the target molecules for the control of immunopathogenic progresses in COPD (显示 ARCN1 ELISA试剂盒).
Results indicate that conjugated-interleukin-2 (IL2 (显示 IL2 ELISA试剂盒)) protein derived from NKTR (显示 NKTR ELISA试剂盒)-214 occupy interleukin-2 (IL2 (显示 IL2 ELISA试剂盒)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (显示 IL2 ELISA试剂盒) protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2 (显示 IL2 ELISA试剂盒)-beta receptor response, to date classically described only in immune cells.
degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor gamma (IL2rgamma)-null mouse model, was examined.
We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2 (显示 RAG2 ELISA试剂盒)-/-IL2Rgnull mice.
Results demonstrate that IL2Rgamma has an onogenic role in JAK3 (显示 JAK3 ELISA试剂盒)-mutation-positive leukemias.
findings demonstrate that NOD SCID (显示 PRKDC ELISA试剂盒) IL2R (显示 IL2RA ELISA试剂盒) common gamma chain -/- mice are capable of engraftment of canine PBLs yet develop graft versus host disease similar to Hu-PBL-SCID (显示 PRKDC ELISA试剂盒) mice
Interleukin-2 (显示 IL2 ELISA试剂盒) signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.
gammac expression was required to signal the differentiation of MHC class I-specific thymocytes into CD8 (显示 CD8A ELISA试剂盒)+ cytotoxic lineage T cells and into invariant natural killer T cells.
analysis of multiorgan metastasis of human HER-2 (显示 ERBB2 ELISA试剂盒)+ breast cancer in Rag2 (显示 RAG2 ELISA试剂盒)-/-;Il2rg-/- mice and treatment with PI3K inhibitor
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
cytokine receptor common subunit gamma
, interleukin 2 receptor gamma
, interleukin 2 receptor, gamma (severe combined immunodeficiency)
, membrane receptor Il2rg
, interleukin 2 receptor, gamma
, CD132 antigen
, IL-2 receptor subunit gamma
, IL-2R subunit gamma
, common cytokine receptor gamma chain
, IL-2R gamma chain
, cytokine receptor common gamma chain
, interleukin-2 receptor gamma chain
, interleukin-2 receptor subunit gamma
, interleukin 2 receptor gamma chain
, common gamma chain
, gamma C receptor