IL15 蛋白 (IL15)产品概述

Full name:
Interleukin 15 蛋白 (IL15)
在www.antibodies-online.cn可供147 Interleukin 15 (IL15) 蛋白的24不同的供货商。 再加上,我们可以发IL15 抗体 (311)IL15 试剂盒 (124)和数多这个蛋白质的别的产品。 总共595 IL15产品已列进来了。
AI503618, IL-15, IL15
列出全部蛋白 基因 基因ID UniProt
IL15 16168 P48346
IL15 3600 P40933
IL15 25670 P97604


按照种类IL15 蛋白 (IL15)


引用最多的IL15 蛋白

  1. Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2667461 : Meresse, Chen, Ciszewski, Tretiakova, Bhagat, Krausz, Raulet, Lanier, Groh, Spies, Ebert, Green, Jabri: Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. in Immunity 2004 (PubMed)
    Show all 10 references for 2667461

  2. Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2667463 : Armitage, Macduff, Eisenman, Paxton, Grabstein: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 8 references for 2667463

  3. Mouse (Murine) IL15 Protein expressed in Escherichia coli (E. coli) - ABIN2666689 : Tang, Zhao, Jiang, Ba, Cui, He: Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice. in Cellular & molecular immunology 2008 (PubMed)
    Show all 8 references for 2666689

  4. Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN1047241 : Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 4 references for 1047241

  5. Mouse (Murine) IL15 Protein expressed in Escherichia coli (E. coli) - ABIN666755 : Olsen, Ota, Kishishita, Kukimoto-Niino, Murayama, Uchiyama, Toyama, Terada, Shirouzu, Kanagawa, Yokoyama: Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for 666755


Chimpanzee Interleukin 15 (IL15) interaction partners

  1. T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.

  2. CD3 (显示 CD3 蛋白)(-) CD8 (显示 CD8A 蛋白)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (显示 IFNG 蛋白), and that IL-15 elicits IFN-gamma (显示 IFNG 蛋白) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (显示 CD8A 蛋白) antigen, IFN-gamma (显示 IFNG 蛋白)]

Mouse (Murine) Interleukin 15 (IL15) interaction partners

  1. findings extend understanding of the differential modes of action between IL-2 (显示 IL2 蛋白) and IL-15, and highlight how, although sharing the CD122 (显示 IL2RB 蛋白)/CD132 (显示 IL2RG 蛋白) receptor, they elicit such different immune actions

  2. IL-15 induced by inflammatory signals in response to lymphodepletion drives lymphocyte responses, as memory CD8 (显示 CD8A 蛋白) T cells proliferated in an IL-15-dependent manner.

  3. these findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies.

  4. developmental arrest of Natural killer cells results from a lack of IL-15 availability in the microenvironment.

  5. IL-15 impacts butyrate-producing bacteria and lowers butyrate levels in the absence of overt pathology, which represent events that precede and promote intestinal inflammatory diseases.

  6. endogenous IL-15 does not directly augment the pathogenesis of sepsis but enables the development of septic shock by maintaining NK cell numbers and integrity.

  7. this study shows that IL-15-mediated control of the precursor population affects the development of virus-specific CD8 (显示 CD8A 蛋白)+ T-cell memory

  8. this study shows that unleashed trans-presentation of IL-15 on MyD88 (显示 MYD88 蛋白)-deficient fibroblastic reticular cells during viral infection fosters the activation of cytotoxic and non-cytotoxic group 1 innate lymphoid cells and accelerates clearance of the virus

  9. this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 and its receptor

  10. Under steady-state conditions, KLF2 (显示 KLF2 蛋白)-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 starvation.

Human Interleukin 15 (IL15) interaction partners

  1. findings extend understanding of the differential modes of action between IL-2 (显示 IL2 蛋白) and IL-15, and highlight how, although sharing the CD122 (显示 IL2RB 蛋白)/CD132 (显示 IL2RG 蛋白) receptor, they elicit such different immune actions

  2. IL-15 drives bystander activation of CD8 (显示 CD8A 蛋白)+ T cells, which predicts disease progression in untreated HIV-1-infected patients and suggests that elevated IL-15 may also drive CD8 (显示 CD8A 蛋白)+ T cell expansion that is linked to increased morbidity and mortality in treated patients

  3. Sustained virologic response was significantly associated with IL15 rs10833 in chronic hepatitis C patients, treated with pegylated interferon-alpha (显示 IFNA 蛋白) and ribavirin.

  4. IL-15 mRNA and protein levels significantly increased in rhHBcAg stimulation group compared with non-stimulated group.

  5. this work provides evidence that the sushi-IL-15Ralpha/IL-15 fusion protein RLI (显示 ABCE1 蛋白) enhances antitumor activity of anti-PD-1 (显示 PDCD1 蛋白) treatment and is a promising approach to stimulate host immunity

  6. These results reveal a novel role of IL-7 (显示 IL7 蛋白) and IL-15 in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells.

  7. This analysis revealed highly connected functional interaction networks with two candidate genes, IL15 and SEC14L5 highly enriched in networks. Overall, from these results, we concluded that these genes can be recommended as some of the potential targets for Post-Traumatic Stress Disorder.

  8. These data support a potential role for IL-15 in the pathogenesis of HIV-associated immune activation.

  9. Cutaneous T-cell lymphoma (CTCL (显示 TSPYL2 蛋白)) pathogenesis remains unknown, and there are no curative therapies. Our findings not only demonstrate a critical role for IL15-mediated inflammation in cutaneous T-cell lymphomagenesis, but also uncover a new oncogenic regulatory loop in CTCL (显示 TSPYL2 蛋白) involving IL15, HDAC1 (显示 HDAC1 蛋白), HDAC6 (显示 HDAC6 蛋白), and miR (显示 MLXIP 蛋白)-21 that shows differential sensitivity to isotype-specific HDAC (显示 HDAC3 蛋白) inhibitors

  10. we provide the first direct evidence that IL-15 is expressed both at the mRNA and protein level in human salivary gland epithelial cells and it is clear that salivary glands from primary Sjogren's syndrome patients showed an intensified epithelial expression of IL-15

Pig (Porcine) Interleukin 15 (IL15) interaction partners

  1. Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.

  2. results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (显示 FYN 蛋白) and NF-kappaB (显示 NFKB1 蛋白) pathways

  3. IFN-gamma (显示 IFNG 蛋白) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response

  4. When induced by IFN-gamma (显示 IFNG 蛋白) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.

Cow (Bovine) Interleukin 15 (IL15) interaction partners

  1. Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (显示 BCL2 蛋白).

Rhesus Monkey Interleukin 15 (IL15) interaction partners

  1. IL 15 generates a dramatic expansion of short-lived memory CD8 (显示 CD8A 蛋白) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (显示 CD4 蛋白)(+) and CD8 (显示 CD8A 蛋白)(+) T cells.

  2. These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (显示 CD4 蛋白) + T cell compartment.

  3. IL-15 secretion significantly correlates with the up-regulated expression of CD4 (显示 CD4 蛋白) on memory CD4 (显示 CD4 蛋白) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.



The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

Alternative names and synonyms associated with IL15

  • interleukin 15 (IL15)
  • interleukin 15 (Il15)
  • AI503618 蛋白
  • IL-15 蛋白
  • IL15 蛋白

Protein level used designations for Interleukin 15 蛋白 (IL15)

interleukin 15 , interleukin-15 , IL-15

737808 Pan troglodytes
100034058 Equus caballus
16168 Mus musculus
3600 Homo sapiens
25670 Rattus norvegicus
403584 Canis lupus familiaris
397683 Sus scrofa
281248 Bos taurus
100009017 Oryctolagus cuniculus
395258 Gallus gallus
100379533 Cavia porcellus
493682 Felis catus
443056 Ovis aries
699616 Macaca mulatta
100484790 Ailuropoda melanoleuca
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