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Rat (Rattus) IL15 ELISA Kit for Sandwich ELISA - ABIN365261
Zanchi, Lira, de Siqueira Filho, Rosa, de Oliveira Carvalho, Seelaender, Santos, Lancha: Chronic low frequency/low volume resistance training reduces pro-inflammatory cytokine protein levels and TLR4 mRNA in rat skeletal muscle. in European journal of applied physiology 2010
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Human IL15 ELISA Kit for Sandwich ELISA - ABIN414877
Shi, Liu, Zhang, Guo, Song, Song, Liu: miR-15b is Downregulated in Myasthenia Gravis Patients and Directly Regulates the Expression of Interleukin-15 (IL-15) in Experimental Myasthenia Gravis Mice. in Medical science monitor : international medical journal of experimental and clinical research 2015
T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (显示 CD3 ELISA试剂盒)(-) CD8 (显示 CD8A ELISA试剂盒)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (显示 IFNG ELISA试剂盒), and that IL-15 elicits IFN-gamma (显示 IFNG ELISA试剂盒) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (显示 CD8A ELISA试剂盒) antigen, IFN-gamma (显示 IFNG ELISA试剂盒)]
this study shows that IL-15-mediated control of the precursor population affects the development of virus-specific CD8 (显示 CD8A ELISA试剂盒)+ T-cell memory
this study shows that unleashed trans-presentation of IL-15 on MyD88 (显示 MYD88 ELISA试剂盒)-deficient fibroblastic reticular cells during viral infection fosters the activation of cytotoxic and non-cytotoxic group 1 innate lymphoid cells and accelerates clearance of the virus
this study shows that synergistic enhancement of adaptive immunity by the combination of epigallo catechin gallate and vitamin A or E is dependent on both IL-15 and its receptor
Under steady-state conditions, KLF2 (显示 KLF2 ELISA试剂盒)-deficient NK cells alter their expression of homeostatic homing receptors and subsequently undergo apoptosis due to IL-15 starvation.
The induction of IgM (显示 CD40LG ELISA试剂盒) and IgA, which can play pivotal roles in mucosal immunity, was promoted in the presence of IL-15. Collectively, the data implicate IL-15 as the master cytokine that induces B-1a cells to mount a mucosal immune response.
The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery.
Muscle FNDC5 (显示 FNDC5 ELISA试剂盒) mRNA expression and irisin (显示 FNDC5 ELISA试剂盒) release are not IL-15-dependent in mice.
Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.
Impaired delivery of IL-15 to CD4 (显示 CD4 ELISA试剂盒)+ T cells in the colon downmodulates Foxp3 (显示 FOXP3 ELISA试剂盒) expression and enhances RORgammat expression. CD4 (显示 CD4 ELISA试剂盒)+ T cells deprived of IL-15 trigger IBD characterized by production of pro-inflammatory cytokines and accumulation of Th1 (显示 HAND1 ELISA试剂盒)/Th17 cells.
Most (86%) IL15 in serum resides in the free state, with a minor proportion (14%) residing in complex with IL15Ralpha. Results suggest that IL15 is released as a free molecule by an unknown mechanism rather than via cleavage of membrane-bound IL15/IL15Ralpha.
These results reveal a novel role of IL-7 (显示 IL7 ELISA试剂盒) and IL-15 in maintaining human T cell function, provide an explanation for T cell dysfunction in humanized mice, and have significant implications for in vitro studies with human T cells.
This analysis revealed highly connected functional interaction networks with two candidate genes, IL15 and SEC14L5 highly enriched in networks. Overall, from these results, we concluded that these genes can be recommended as some of the potential targets for Post-Traumatic Stress Disorder.
These data support a potential role for IL-15 in the pathogenesis of HIV-associated immune activation.
Cutaneous T-cell lymphoma (CTCL (显示 TSPYL2 ELISA试剂盒)) pathogenesis remains unknown, and there are no curative therapies. Our findings not only demonstrate a critical role for IL15-mediated inflammation in cutaneous T-cell lymphomagenesis, but also uncover a new oncogenic regulatory loop in CTCL (显示 TSPYL2 ELISA试剂盒) involving IL15, HDAC1 (显示 HDAC1 ELISA试剂盒), HDAC6 (显示 HDAC6 ELISA试剂盒), and miR (显示 MLXIP ELISA试剂盒)-21 that shows differential sensitivity to isotype-specific HDAC (显示 HDAC3 ELISA试剂盒) inhibitors
we provide the first direct evidence that IL-15 is expressed both at the mRNA and protein level in human salivary gland epithelial cells and it is clear that salivary glands from primary Sjogren's syndrome patients showed an intensified epithelial expression of IL-15
Data show a greater expression of interleukin 15 (IL-15) mRNA in healing wounds compared with non-healing wounds.
Our study indicates that the IL15 +96522A/C polymorphism correlates with the severity of Hashimoto's disease (HD), most likely by increasing Th17 cells.
this study shows that IL-15 induces cytokine-induced killer cells with a potent cytotoxic activity mostly against tumor cells from epithelial solid malignancies via NKG2D (显示 KLRK1 ELISA试剂盒)-mediated mechanism.
IL-15 is able to significantly regulate the inflammatory infiltration of macrophages in polymyositis patients through affecting the NF-kB pathway and MMP-9 (显示 MMP9 ELISA试剂盒) expression levels.
IL-15 mRNA expression was significantly higher in patients with moderately severe viral bronchiolitis compared to controls and patients with severe disease. Serum IL15 correlated with disease severity.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (显示 FYN ELISA试剂盒) and NF-kappaB (显示 NFKB1 ELISA试剂盒) pathways
IFN-gamma (显示 IFNG ELISA试剂盒) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (显示 IFNG ELISA试剂盒) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (显示 BCL2 ELISA试剂盒).
IL 15 generates a dramatic expansion of short-lived memory CD8 (显示 CD8A ELISA试剂盒) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (显示 CD4 ELISA试剂盒)(+) and CD8 (显示 CD8A ELISA试剂盒)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (显示 CD4 ELISA试剂盒) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (显示 CD4 ELISA试剂盒) on memory CD4 (显示 CD4 ELISA试剂盒) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.