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抗Mouse (Murine) IL15 抗体:
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抗Rat (Rattus) IL15 抗体:
Human Monoclonal IL15 Primary Antibody for CyTOF, FACS - ABIN4900389
Marra, Mathew, Grigoriadis, Wu, Kyle-Cezar, Watkins, Rashid, De Rinaldis, Hessey, Gazinska, Hayday, Tutt: IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. in Cancer research 2014
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Human Monoclonal IL15 Primary Antibody for CyTOF, FACS - ABIN4900390
Ong, Hamid, Travers, Strickland, Al Kerithy, Boguniewicz, Leung: Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Human Monoclonal IL15 Primary Antibody for FACS - ABIN4897621
Anguille, Van Acker, Van den Bergh, Willemen, Goossens, Van Tendeloo, Smits, Berneman, Lion: Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. in PLoS ONE 2015
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Human Polyclonal IL15 Primary Antibody for FACS, WB - ABIN4900388
Tejman-Yarden, Zlotnik, Lewis, Etzion, Chaimovitz, Douvdevani: Renal cells express a functional interleukin-15 receptor. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005
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Human Monoclonal IL15 Primary Antibody for FACS - ABIN4897620
Ferlazzo, Pack, Thomas, Paludan, Schmid, Strowig, Bougras, Muller, Moretta, Münz: Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Monoclonal IL15 Primary Antibody for - ABIN1383961
Bernard, Harb, Mortier, Quéméner, Meloen, Vermot-Desroches, Wijdeness, van Dijken, Grötzinger, Slootstra, Plet, Jacques: Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. in The Journal of biological chemistry 2004
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Human Polyclonal IL15 Primary Antibody for ELISA, WB - ABIN4324547
Schneider, Mohebiany, Ifergan, Beauseigle, Duquette, Prat, Arbour: B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. in Journal of immunology (Baltimore, Md. : 1950) 2011
Human Polyclonal IL15 Primary Antibody for Func, IHC (p) - ABIN2474939
Miller: T4 DNA polymerase (gene 43) is required in vivo for repair of gaps in recombinants. in Journal of virology 1975
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T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (显示 CD3 抗体)(-) CD8 (显示 CD8A 抗体)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (显示 IFNG 抗体), and that IL-15 elicits IFN-gamma (显示 IFNG 抗体) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (显示 CD8A 抗体) antigen, IFN-gamma (显示 IFNG 抗体)]
findings indicated that IL-15 plays an important role in preventing leukemia development.
NK cells activated by IL-4 (显示 IL4 抗体) in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity.
Genetic ablation of the IL2Rbeta chain on CD8 (显示 CD8A 抗体)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (显示 CD244 抗体) and Tim-3 (显示 HAVCR2 抗体); precludes terminal differentiation of highly defective PD-1 (显示 PDCD1 抗体)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (显示 IL7 抗体)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 (显示 IL2 抗体) and IL-15 as instigators of CD8 (显示 CD8A 抗体)(+) T-cell exhaustion during chronic viral infe...
aerobic interval training enhanced the anti-inflammatory indices IL-10 (显示 IL10 抗体)/TNF-alpha (显示 TNF 抗体) ratio and IL-15 expression in skeletal muscle in tumor-bearing mice.
this study reveals the function of IL-15 in astrocyte survival via Akt (显示 AKT1 抗体) phosphorylation in response to OGD (显示 FGFR1 抗体)-induced damage.
Our new compelling findings have established the critical roles of both IL-7 (显示 IL7 抗体) and IL-15 in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 (显示 IL7 抗体) and IL-15 further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders.
results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease
homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment.
Recombinant IL-15 is a promising agent for cancer immunotherapy both in humans and animals.
Taken together, these data suggest that CCR7 (显示 CCR7 抗体) biases memory CD8 (显示 CD8A 抗体) T cells toward IL-7 (显示 IL7 抗体)-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
IL-15 levels were found to be elevated in depressed patients with asthma.
this paper show that IL-15 boosts the function and migration of human terminally differentiated CD8 (显示 CD8A 抗体)+ T cells by inducing a unique gene signature
inhibits the Ca(2 (显示 CA2 抗体)+)-induced differentiation of keratinocytes, mainly via the attenuation of Ca(2 (显示 CA2 抗体)+)-stimulated PI3K (显示 PIK3CA 抗体)-AKT (显示 AKT1 抗体) signalling
The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33 (显示 CD33 抗体)(+) HL-60 targets and increased NK survival and proliferation.
In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway.
n this study, authors compared the concentrations of IL-15 and IL-7 (显示 IL7 抗体) in the plasma of MDS (显示 PAFAH1B1 抗体) patients (n = 20) compared with that in the plasma of healthy controls (n = 20). Results indicated that exposure to high levels of IL-15 may be involved in the T cell phenotype conversion observed in MDS (显示 PAFAH1B1 抗体).
the critical role played by IL-7 and IL-15 in T cell homeostasis and how these cytokines could be used to improve immune reconstitution after allogeneic SCT.
Downregulation of Hsc70 (显示 HSPA8 抗体), Hsp70 (显示 HSP70 抗体), and IL-15 expression at gene and/or protein levels might support the retention of fertilization products in cases of missed abortion and blighted ovum.
The presence of IL15 rs10833 AA genotype in HIV-/HCV-co-infected patients was associated with advanced liver fibrosis, inflammation-related biomarkers and increased rates of sustained virological response to pegIFN-alpha/RBV therapy.
High IL15 expression is associated with endometriosis.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (显示 FYN 抗体) and NF-kappaB (显示 NFKB1 抗体) pathways
IFN-gamma (显示 IFNG 抗体) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (显示 IFNG 抗体) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (显示 BCL2 抗体).
IL 15 generates a dramatic expansion of short-lived memory CD8 (显示 CD8A 抗体) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (显示 CD4 抗体)(+) and CD8 (显示 CD8A 抗体)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (显示 CD4 抗体) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (显示 CD4 抗体) on memory CD4 (显示 CD4 抗体) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.