IL12B 蛋白 (IL12B)产品概述

Full name:
Interleukin 12b 蛋白 (IL12B)
在www.antibodies-online.cn可供86 Interleukin 12b (IL12B) 蛋白的19不同的供货商。 再加上,我们可以发IL12B 抗体 (247)IL12B 试剂盒 (117)和数多这个蛋白质的别的产品。 总共476 IL12B产品已列进来了。
CLMF, CLMF2, IL-12, IL-12.p40, Il-12b, IL-12p40, Il12, IL12B, IL12p40, NKSF, NKSF2, p40
列出全部蛋白 基因 基因ID UniProt
IL12B 16160 P43432
IL12B 64546  
IL12B 3593 P29460


按照种类IL12B 蛋白 (IL12B)


引用最多的IL12B 蛋白

  1. Rat (Rattus) IL12B Protein expressed in Human Cells - ABIN2009536 : Sieburth, Jabs, Warrington, Li, Lasota, LaForgia, Kelleher, Huebner, Wasmuth, Wolf: Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. in Genomics 1992 (PubMed)
    Show all 5 references for 2009536

  2. Mouse (Murine) IL12B Protein expressed in Human Cells - ABIN2008511 : Gearing, Cosman: Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. in Cell 1991 (PubMed)
    Show all 5 references for 2008511

  3. Human IL12B Protein expressed in Human Cells - ABIN2001973 : Thierfelder, van Deursen, Yamamoto, Tripp, Sarawar, Carson, Sangster, Vignali, Doherty, Grosveld, Ihle: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. in Nature 1996 (PubMed)
    Show all 5 references for 2001973

  4. Mouse (Murine) IL12B Protein expressed in Human Cells - ABIN2008513 : Ling, Gately, Gubler, Stern, Lin, Hollfelder, Su, Pan, Hakimi: Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. in Journal of immunology (Baltimore, Md. : 1950) 1995 (PubMed)
    Show all 4 references for 2008513

  5. Marmoset IL12B Protein expressed in Human Cells - ABIN2010101 : Kato, Shimozato, Hoshi, Wakimoto, Hamada, Yagita, Okumura: Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 4 references for 2010101

  6. Rat (Rattus) IL12B Protein expressed in Human Cells - ABIN2009538 : Kim, Loveland, Sitz, Ratto Kim, Mclinden, Tencer, Davis, Burke, Boswell, Redfield, Birx: Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1. in Clinical and experimental immunology 1997 (PubMed)
    Show all 4 references for 2009538

  7. Human IL12B Protein expressed in Escherichia coli (E. coli) - ABIN1047232 : Wolf, Temple, Kobayashi, Young, Dicig, Lowe, Dzialo, Fitz, Ferenz, Hewick: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. in Journal of immunology (Baltimore, Md. : 1950) 1991 (PubMed)
    Show all 3 references for 1047232

  8. Human IL12B Protein expressed in Hi-5 - ABIN1098598 : Oppmann, Lesley, Blom, Timans, Xu, Hunte, Vega, Yu, Wang, Singh, Zonin, Vaisberg, Churakova, Liu, Gorman, Wagner, Zurawski, Liu, Abrams, Moore, Rennick, de Waal-Malefyt, Hannum, Bazan, Kastelein: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. in Immunity 2001 (PubMed)
    Show all 2 references for 1098598


Mouse (Murine) Interleukin 12b (IL12B) interaction partners

  1. this study shows that a systemic IL-12 (显示 IL12A 蛋白) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis

  2. this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (显示 IL12A 蛋白) production is inhibited by TLR stimulation from the plasma membrane

  3. Irradiation-induced IL-6 (显示 IL6 蛋白) can decrease IL-12 (显示 IL12A 蛋白) production through the inhibition of C-Rel (显示 NFkBP65 蛋白) phosphorylation by the IL-6 (显示 IL6 蛋白)/STAT3 (显示 STAT3 蛋白) signaling pathway.

  4. The IL-12 (显示 IL12A 蛋白) response by dendritic cells against S. aureus is highly growth phase dependent.

  5. the PI3K pathway mediated IL-12 (显示 IL12A 蛋白) inhibition but did not interfere with the inhibition of IL-23 (显示 IL23A 蛋白) or stimulation of IL-10 (显示 IL10 蛋白).

  6. Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.

  7. this study demonstrates viral RNA analog-induced transcription synergy of Il6 (显示 IL6 蛋白) and Il12b via IFN regulatory factor (IRF)1 (显示 IRF1 蛋白) (TLR3 (显示 TLR3 蛋白)-TIR domain-containing adaptor inducing IFN-beta (显示 TICAM1 蛋白) [TRIF (显示 RNF138 蛋白)] responsive), C/EBPbeta (显示 CEBPB 蛋白) (TLR7 (显示 TLR7 蛋白)-MyD88 (显示 MYD88 蛋白) responsive), and JunB (显示 JUNB 蛋白) (all responsive).

  8. These findings reveal a critical role for IL-12 (显示 IL12A 蛋白) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.

  9. our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.

  10. The systemic IL-10 (显示 IL10 蛋白)/IL-12 (显示 IL12A 蛋白) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (显示 IL10 蛋白) and polarization of neutrophils into an anti-inflammatory IL-12 (显示 IL12A 蛋白)-negative phenotype.

Human Interleukin 12b (IL12B) interaction partners

  1. Pre-incubation with IL-12 (显示 IL12A 蛋白) was able to restore IFN-gamma (显示 IFNG 蛋白) production and the cytotoxicity capacities of NK cells. This cytokine may therefore be considered as a potential treatment candidate in traumatic brain injury patients with immune suppression.

  2. NOD2 rs3135500 and IL12B rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.

  3. assembly-induced folding is key in IL-12 (显示 IL12A 蛋白) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (显示 IL12A 蛋白) cytokine

  4. IL-12B gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients

  5. this study shows that that IL-12 (显示 IL12A 蛋白) and IL-4 (显示 IL4 蛋白) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation

  6. The data suggested the association of IL12B with the psoriasis, however no evidence was observed for the epistatic effect of IL12B with HLA-Cw6 among the psoriasis patients in India.

  7. In summary, this meta-analysis finds that IL6 (显示 IL6 蛋白) rs1800795 and IL18 (显示 IL18 蛋白) rs1946518 polymorphisms decrease the risk of BD. However, IL12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary.

  8. Suggest Il12B SNPs as genetic marker of disease severity in Takayasu arteritis severity.

  9. The results of this study suggested that rs6887695 SNP in IL12B gene increase susceptibility to relapsing-remitting multiple sclerosis.

  10. The results of this case-control study suggest that IL-12A (显示 IL12A 蛋白), IL-12B, IL12RB1 (显示 IL12RB1 蛋白), IL12RB2 (显示 IL12RB2 蛋白) and IL23R (显示 IL23R 蛋白) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations

Cow (Bovine) Interleukin 12b (IL12B) interaction partners

  1. The results showed that the expression of TNF-alpha (显示 TNF 蛋白), iNOS (显示 NOS2 蛋白), and IL-6 (显示 IL6 蛋白) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (显示 IL12A 蛋白) was unaffected.[IL-6 (显示 IL6 蛋白), IL-12 (显示 IL12A 蛋白)]

  2. study investigated hypothesis that CD40 (显示 CD40 蛋白) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (显示 NOS2 蛋白) and IL-12p40 genes downstream of p38 (显示 MAPK14 蛋白)

Rhesus Monkey Interleukin 12b (IL12B) interaction partners

  1. In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (显示 TLR7 蛋白)/8 and TLR-9 (显示 TLR9 蛋白) stimulation, which could potentially affect their response to vaccination and viral infection.

Pig (Porcine) Interleukin 12b (IL12B) interaction partners

  1. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (显示 TNF 蛋白), IL-6 (显示 IL6 蛋白), IL-12p40, IL-1beta (显示 IL1B 蛋白), and resulted in increased expression of the apoptosis initiator caspase-8 (显示 CASP8 蛋白) and bcl2L1 (显示 BCL2L1 蛋白).



This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative names and synonyms associated with IL12B

  • interleukin 12 p40 subunit (IL-12)
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)
  • interleukin 12b (Il12b)
  • interleukin 12B (Il12b)
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B)
  • CLMF 蛋白
  • CLMF2 蛋白
  • IL-12 蛋白
  • IL-12.p40 蛋白
  • Il-12b 蛋白
  • IL-12p40 蛋白
  • Il12 蛋白
  • IL12B 蛋白
  • IL12p40 蛋白
  • NKSF 蛋白
  • NKSF2 蛋白
  • p40 蛋白

Protein level used designations for Interleukin 12b 蛋白 (IL12B)

CLMF p40 , Cytotoxic lymphocyte maturation factor 40 kDa subunit , IL-12 subunit p40 , Interleukin-12 subunit beta , CLMF p35 , IL-12 subunit p35 , IL-12A , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12B , interleukin-12 p35 subunit , interleukin-12 subunit alpha , IL-12 p40 , IL-23 subunit p40 , cytotoxic lymphocyte maturation factor 40 kDa subunit , interleukin-12 subunit beta , interleukin-12 p40 , IL-12B , interleukin-12 p40 subunit , IL12, subunit p40 , NK cell stimulatory factor chain 2 , interleukin 12, p40 , interleukin-12 beta chain , natural killer cell stimulatory factor, 40 kD subunit , interleukin 12 40kDa subunit , interleukin 12 p40 subunit , interleukin-12 p40 chain , IL-12 p40 subunit , interleukin-12p40

100860845 Capra hircus
403977 Canis lupus familiaris
16160 Mus musculus
64546 Rattus norvegicus
100135554 Cavia porcellus
3593 Homo sapiens
281857 Bos taurus
443472 Ovis aries
403976 Canis lupus familiaris
100034222 Equus caballus
768273 Felis catus
694747 Macaca mulatta
404671 Gallus gallus
397076 Sus scrofa
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