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抗Mouse (Murine) IL12B 抗体:
抗Rat (Rattus) IL12B 抗体:
抗Human IL12B 抗体:
Human Monoclonal IL12B Primary Antibody for IHC (fro), ELISA - ABIN2474931
Carter, Patel, Stanley, Ingham, Wadhwa, Bird, Thorpe, Selby, Banks: Production and characterization of monoclonal antibodies to human interleukin-12. in Hybridoma 1997
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Human Polyclonal IL12B Primary Antibody for IHC (p), WB - ABIN2176964
Li, Dan, Nie, Hu, Gesang, Bianba, Ze, Ciren: CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts. in Molecular medicine reports 2015
Human Monoclonal IL12B Primary Antibody for ELISA - ABIN2689727
DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. in The Journal of experimental medicine 1992
Human Polyclonal IL12B Primary Antibody for ELISA, IHC - ABIN4325518
Sheth, De, Nolan, Friel, Duffy, Ricciardi, Miller-Graziano, Bankey: Heat shock protein 27 inhibits apoptosis in human neutrophils. in The Journal of surgical research 2001
Human Monoclonal IL12B Primary Antibody for FACS - ABIN4898082
Napoletano, Zizzari, Rughetti, Rahimi, Irimura, Clausen, Wandall, Belleudi, Bellati, Pierelli, Frati, Nuti: Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. in European journal of immunology 2012
Mouse (Murine) Polyclonal IL12B Primary Antibody for ELISA, WB - ABIN408670
Stäger, Maroof, Zubairi, Sanos, Kopf, Kaye: Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. in European journal of immunology 2006
Mouse (Murine) Polyclonal IL12B Primary Antibody for ELISA, WB - ABIN238549
Gui, Xiong, Yang, Li, Huang: Effects of acupuncture on LIF and IL-12 in rats of implantation failure. in American journal of reproductive immunology (New York, N.Y. : 1989) 2012
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this study shows that a systemic IL-12 (显示 IL12A 抗体) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (显示 IL12A 抗体) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (显示 IL6 抗体) can decrease IL-12 (显示 IL12A 抗体) production through the inhibition of C-Rel (显示 NFkBP65 抗体) phosphorylation by the IL-6 (显示 IL6 抗体)/STAT3 (显示 STAT3 抗体) signaling pathway.
The IL-12 (显示 IL12A 抗体) response by dendritic cells against S. aureus is highly growth phase dependent.
the PI3K pathway mediated IL-12 (显示 IL12A 抗体) inhibition but did not interfere with the inhibition of IL-23 (显示 IL23A 抗体) or stimulation of IL-10 (显示 IL10 抗体).
Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.
this study demonstrates viral RNA analog-induced transcription synergy of Il6 (显示 IL6 抗体) and Il12b via IFN regulatory factor (IRF)1 (显示 IRF1 抗体) (TLR3 (显示 TLR3 抗体)-TIR domain-containing adaptor inducing IFN-beta (显示 TICAM1 抗体) [TRIF (显示 RNF138 抗体)] responsive), C/EBPbeta (显示 CEBPB 抗体) (TLR7 (显示 TLR7 抗体)-MyD88 (显示 MYD88 抗体) responsive), and JunB (显示 JUNB 抗体) (all responsive).
These findings reveal a critical role for IL-12 (显示 IL12A 抗体) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.
our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.
The systemic IL-10 (显示 IL10 抗体)/IL-12 (显示 IL12A 抗体) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (显示 IL10 抗体) and polarization of neutrophils into an anti-inflammatory IL-12 (显示 IL12A 抗体)-negative phenotype.
IL-12B -1188 C allele may be a protective factor against asthma in East Asians
The low expression of HDAC3 (显示 HDAC3 抗体) and overexpession of inflammatory cytokines (IL-18 (显示 IL18 抗体), IL-12 (显示 IL12A 抗体) and TNF-alpha (显示 TNF 抗体)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
Polymorphisms of IFNG (显示 IFNG 抗体), IL12B and IL12RB1 (显示 IL12RB1 抗体) genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
Identification of PARP-1 (显示 PARP1 抗体) as a unique regulator of Il12b transcription in response to inflammatory insults in an allele-differentiating manner
Pre-incubation with IL-12 (显示 IL12A 抗体) was able to restore IFN-gamma (显示 IFNG 抗体) production and the cytotoxicity capacities of NK cells. This cytokine may therefore be considered as a potential treatment candidate in traumatic brain injury patients with immune suppression.
NOD2 (显示 NOD2 抗体) rs3135500 and IL12B rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.
assembly-induced folding is key in IL-12 (显示 IL12A 抗体) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (显示 IL12A 抗体) cytokine
IL-12B gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients
this study shows that that IL-12 (显示 IL12A 抗体) and IL-4 (显示 IL4 抗体) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation
The data suggested the association of IL12B with the psoriasis, however no evidence was observed for the epistatic effect of IL12B with HLA-Cw6 among the psoriasis patients in India.
The results showed that the expression of TNF-alpha (显示 TNF 抗体), iNOS (显示 NOS2 抗体), and IL-6 (显示 IL6 抗体) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (显示 IL12A 抗体) was unaffected.[IL-6 (显示 IL6 抗体), IL-12 (显示 IL12A 抗体)]
study investigated hypothesis that CD40 (显示 CD40 抗体) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (显示 NOS2 抗体) and IL-12p40 genes downstream of p38 (显示 MAPK14 抗体)
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (显示 TLR7 抗体)/8 and TLR-9 (显示 TLR9 抗体) stimulation, which could potentially affect their response to vaccination and viral infection.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (显示 TNF 抗体), IL-6 (显示 IL6 抗体), IL-12p40, IL-1beta (显示 IL1B 抗体), and resulted in increased expression of the apoptosis initiator caspase-8 (显示 CASP8 抗体) and bcl2L1 (显示 BCL2L1 抗体).
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, IL-12 subunit p40
, Interleukin-12 subunit beta
, CLMF p35
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12B
, interleukin-12 p35 subunit
, interleukin-12 subunit alpha
, IL-12 p40
, IL-23 subunit p40
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin-12 subunit beta
, interleukin-12 p40
, interleukin-12 p40 subunit
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, interleukin 12, p40
, interleukin-12 beta chain
, natural killer cell stimulatory factor, 40 kD subunit
, interleukin 12 40kDa subunit
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, IL-12 p40 subunit