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These data suggest that plasmacytoid dendritic cells producing IFN-alpha (显示 IFNA ELISA试剂盒) and IL-33 (显示 IL33 ELISA试剂盒) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (显示 CCL1 ELISA试剂盒) expression including CCL2 (显示 CCL2 ELISA试剂盒).
this study shows that the presence of IFN-alpha (显示 IFNA ELISA试剂盒) at antigen sensitization activates an IDO1 (显示 IDO1 ELISA试剂盒)/TGF-beta (显示 TGFB1 ELISA试剂盒)-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells
these studies demonstrate an important role for type I IFN in skin fibrosis, and they provide a rationale for IFNAR1 inhibition in scleroderma
These results identify a key interface created by IFNAR1 residues Tyr (显示 TYR ELISA试剂盒)(240) and Tyr (显示 TYR ELISA试剂盒)(274) interacting with IFN-beta (显示 IFNB1 ELISA试剂盒) residues Phe(63), Leu(64), Glu (显示 GCG ELISA试剂盒)(77), Thr (显示 TRH ELISA试剂盒)(78), Val(81), and Arg(82) that underlie IFN-beta (显示 IFNB1 ELISA试剂盒)-IFNAR1-mediated signaling and biological processes.
IFNAR1-deficiency accelerated humoral immune responses and parasite control by boosting ICOS (显示 ICOS ELISA试剂盒)-signalling in two non-lethal murine models of malaria
reduced type I interferon (显示 IFNA ELISA试剂盒) production in obesity is caused by SOCS3 (显示 SOCS3 ELISA试剂盒) overexpression as well as tolerance induced by leptin (显示 LEP ELISA试剂盒)
Downregulation of IFNAR1 promotes melanoma development and progression. IFNAR1 mutation, which is partially resistant to downregulation, delays melanoma development.
The study provides evidence for the importance of brain endothelial and epithelial cells in the communication between the Central Nervous System and the immune system, and demonstrates tissue specific IFNAR1 engagement during sickness behavior.
Data show that both NF-kappaB (NF-kappaB (显示 NFKB1 ELISA试剂盒)) and tonic interferon (显示 IFNA ELISA试剂盒) signals are involved in the final maturation of thymocytes into naive T cells.
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche.
These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication.
On one hand, hepatitis B virus activates MMP-9 (显示 MMP9 ELISA试剂盒) in infected patients and leukocytes. On the other hand, MMP-9 (显示 MMP9 ELISA试剂盒) facilitates hepatitis B virus replication through repressing IFN/JAK (显示 JAK3 ELISA试剂盒)/STAT (显示 STAT1 ELISA试剂盒) signaling, IFNAR1 function, and IFN-alpha (显示 IFNA ELISA试剂盒) action.
this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo (显示 MITF ELISA试剂盒) in Estonian patients
A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1.
rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations.
Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection.
data illustrate a lipid G-protein coupled receptor (GPCR (显示 TAS1R3 ELISA试剂盒))-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 (显示 S1PR1 ELISA试剂盒) signaling
Data suggest IFNA2 (interferon (显示 IFNA ELISA试剂盒), alpha 2) binding to extracellular domain of IFNAR1 or IFNAR2 (显示 IFNAR2 ELISA试剂盒) promotes proximity between intracellular domains; signaling depends on duration of activation/affinity of binding rather than specific conformational changes.
Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 (显示 IFNA2 ELISA试剂盒) generates type I IFN competitive antagonists.
The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNAR1 gene was determined.
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
interferon alpha/beta receptor 1
, interferon receptor
, soluble receptor
, interferon-alpha receptor 1
, putative interferon-alpha/beta receptor alpha chain
, interferon receptor 1
, interferon (alpha, beta and omega) receptor 1
, interferon alpha/beta receptor 1-like
, IFN-alpha/beta receptor 1
, INF-a receptor
, interferon-alpha/beta receptor 1
, type I interferon receptor 1
, alpha-type antiviral protein
, beta-type antiviral protein
, cytokine receptor class-II member 1
, cytokine receptor family 2 member 1
, interferon-alpha/beta receptor alpha chain
, interferon-beta receptor 1
, interferon (alpha and beta) receptor 1
, interferon, alpha; receptor
, Interferon-alpha/beta receptor alpha chain