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抗Mouse (Murine) IFNAR1 抗体:
抗Human IFNAR1 抗体:
抗Rat (Rattus) IFNAR1 抗体:
Human Polyclonal IFNAR1 Primary Antibody for CyTOF, FACS - ABIN4900075
Lin, Liao, Lin, Lin: Blocking of the alpha interferon-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection. in Journal of virology 2004
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Human Monoclonal IFNAR1 Primary Antibody for FACS - ABIN4897147
Ramachandran, Yu, Dyczynski, Baskaran, Zhang, Lulla, Lulla, Saul, Nelander, Dimberg, Merits, Leja-Jarblad, Essand: Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
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Human Monoclonal IFNAR1 Primary Antibody for FACS - ABIN4897145
Stone, Giugliano, Schnell, Cheng, Leahy, Golden-Mason, Gale, Rosen: Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. in PLoS pathogens 2013
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Human Monoclonal IFNAR1 Primary Antibody for CyTOF, FACS - ABIN4900073
Zhou, Huang, Poon, Chen, Chan, Ng, Guan, Watt, Lu, Yuen, Zheng: Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. in Journal of hepatology 2009
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Human Monoclonal IFNAR1 Primary Antibody for CyTOF, FACS - ABIN4900074
Madrid, Ganem: Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. in Journal of virology 2012
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Rat (Rattus) Polyclonal IFNAR1 Primary Antibody for IHC, WB - ABIN152597
Kumar, Krolewski, Fuchs: Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. in The Journal of biological chemistry 2004
Human Monoclonal IFNAR1 Primary Antibody for FACS - ABIN4897143
Fuchs, Kaiser-Labusch, Bank, Ammann, Kolb-Kokocinski, Edelbusch, Omran, Ehl: Tyrosine kinase 2 is not limiting human antiviral type III interferon responses. in European journal of immunology 2016
Results show that removal of type-1 IFN signalling in the APPSWE/PS1DeltaE9 mouse model of AD confers a predominantly anti-inflammatory glial response and protects from cognitive decline. However this phenotype does not correlate with alterations in amyloid deposition and only a modest reduction in Abeta (显示 APP 抗体) monomer levels.
transfusion-induced differentiation of IFNAR1(-/-) B cells into germinal center B cells and plasma cells was significantly reduced, compared to WT B cells. This study demonstrates that B cells require signaling from IFN-alpha (显示 IFNA 抗体)/beta to produce alloantibodies to the human KEL glycoprotein in mice.
These data suggest that plasmacytoid dendritic cells producing IFN-alpha (显示 IFNA 抗体) and IL-33 (显示 IL33 抗体) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (显示 CCL1 抗体) expression including CCL2 (显示 CCL2 抗体).
this study shows that the presence of IFN-alpha (显示 IFNA 抗体) at antigen sensitization activates an IDO1 (显示 IDO1 抗体)/TGF-beta (显示 TGFB1 抗体)-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells
these studies demonstrate an important role for type I IFN in skin fibrosis, and they provide a rationale for IFNAR1 inhibition in scleroderma
These results identify a key interface created by IFNAR1 residues Tyr (显示 TYR 抗体)(240) and Tyr (显示 TYR 抗体)(274) interacting with IFN-beta (显示 IFNB1 抗体) residues Phe(63), Leu(64), Glu (显示 GCG 抗体)(77), Thr (显示 TRH 抗体)(78), Val(81), and Arg(82) that underlie IFN-beta (显示 IFNB1 抗体)-IFNAR1-mediated signaling and biological processes.
IFNAR1-deficiency accelerated humoral immune responses and parasite control by boosting ICOS (显示 ICOS 抗体)-signalling in two non-lethal murine models of malaria
reduced type I interferon (显示 IFNA 抗体) production in obesity is caused by SOCS3 (显示 SOCS3 抗体) overexpression as well as tolerance induced by leptin (显示 LEP 抗体)
Downregulation of IFNAR1 promotes melanoma development and progression. IFNAR1 mutation, which is partially resistant to downregulation, delays melanoma development.
Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer.
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche.
These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication.
On one hand, hepatitis B virus activates MMP-9 (显示 MMP9 抗体) in infected patients and leukocytes. On the other hand, MMP-9 (显示 MMP9 抗体) facilitates hepatitis B virus replication through repressing IFN/JAK (显示 JAK3 抗体)/STAT (显示 STAT1 抗体) signaling, IFNAR1 function, and IFN-alpha (显示 IFNA 抗体) action.
this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo (显示 MITF 抗体) in Estonian patients
A small proportion of both pancreatic and periampullary tumors showed a strong expression of the IFNAR-1.
rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations.
Genetic polymorphisms of the promoter of INFAR gene represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection.
data illustrate a lipid G-protein coupled receptor (GPCR (显示 TAS1R3 抗体))-IFNAR1 regulatory loop that balances effective and detrimental immune responses and elevated endogenous S1PR1 (显示 S1PR1 抗体) signaling
Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 (显示 IFNA2 抗体) generates type I IFN competitive antagonists.
The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNAR1 gene was determined.
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
interferon alpha/beta receptor 1
, interferon receptor
, soluble receptor
, interferon-alpha receptor 1
, putative interferon-alpha/beta receptor alpha chain
, interferon receptor 1
, interferon (alpha, beta and omega) receptor 1
, interferon alpha/beta receptor 1-like
, IFN-alpha/beta receptor 1
, INF-a receptor
, interferon-alpha/beta receptor 1
, type I interferon receptor 1
, alpha-type antiviral protein
, beta-type antiviral protein
, cytokine receptor class-II member 1
, cytokine receptor family 2 member 1
, interferon-alpha/beta receptor alpha chain
, interferon-beta receptor 1
, interferon (alpha and beta) receptor 1
, interferon, alpha; receptor
, Interferon-alpha/beta receptor alpha chain