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IFNa (显示 IFNA ELISA试剂盒) and IFNc show similar antiviral activities and ability to induce antiviral genes in lymphoid tissues.
Data indicate that the combination of AAV2.IL-4 (显示 IL4 ELISA试剂盒) and AAV2.IFN-alpha (显示 IFNA ELISA试剂盒) was not significantly different as compared to AAV2.IL-4 (显示 IL4 ELISA试剂盒) alone.
Infecting virus and the target cell type dictate the extent and signature of inducible IFN-alpha2 gene expression.
Mutation of the IFNAR-1 (显示 IFNAR1 ELISA试剂盒) receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists.
produced in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus in lymph nodes cells expressing the myeloid markers CD14 (显示 CD14 ELISA试剂盒), CD11b (显示 ITGAM ELISA试剂盒), and CD172a (显示 SIRPA ELISA试剂盒)
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (显示 STAT1 ELISA试剂盒) and, to a lesser extent, STAT2 (显示 STAT2 ELISA试剂盒).
Interferon-alpha (显示 IFNA ELISA试剂盒)-induced CD100 (显示 SEMA4D ELISA试剂盒) expression on naive CD8 (显示 CD8A ELISA试剂盒)(+) T cells enhances antiviral responses to hepatitis C infection through CD72 (显示 CD72 ELISA试剂盒) signal transduction.
Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function on exposure to IFN-alpha2a and IFN-gamma (显示 IFNG ELISA试剂盒).
Increase in serum IFNA2 is associated with adenoma.
Data suggest IFNA2 binding to extracellular domain of IFN receptors IFNAR1 (显示 IFNAR1 ELISA试剂盒) or IFNAR2 (显示 IFNAR2 ELISA试剂盒) promotes proximity between intracellular domains; signaling depends on duration of activation and affinity of binding rather than specific conformational changes.
Report biased expression of human interferon alpha-2b and Escherichia coli methionine amino peptidase genes under control of single promoter in E. coli.
interferon alpha-2b gene mutations were identified among brain tumor patients; highest percentage of frameshift mutations was identified; patients were found to be under environmental stress from contaminated drinking water and from local gamma radiations
PPARalpha (显示 PPARA ELISA试剂盒) activation by an agonist WY-14643 could potentiate IFN-alpha (显示 IFNA ELISA试剂盒) responses, reverse IFN-alpha (显示 IFNA ELISA试剂盒) refractoriness, and enhance viral eradication in hepatocytes.
The chronic use of low dose of radiations by occupational workers has a significant correlation with mutational effects on interferon alpha 2b gene, further evident by depressed interferon alpha (显示 IFNA ELISA试剂盒) levels in serum.
IFN-beta (显示 IFNB1 ELISA试剂盒) was significantly more effective than IFNA2 in protecting human head and neck squamous cell carcinoma lines from oncolysis by vesicular stomatitis.
The structure, mechanism of action and biological activities of IFNalpha2. [Review]
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold.
, interferon alpha 2
, interferon alpha family, gene 2
, interferon alpha A
, IFN-alpha 2
, interferon-alpha 2
, alpha-2a interferon
, interferon alpha 2a
, interferon alpha 2b
, leIF A