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Phospholipase C beta connects G protein signaling with RNA interference. (Review)
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (显示 SOX10 ELISA试剂盒) expression and presence of the BRAF (显示 BRAF ELISA试剂盒) V600E mutation.
Mutations in GNAQ and GNA11 (显示 GNA11 ELISA试剂盒) genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
These results indicate that the mechanism by which Galphaq and PLC (显示 HSPG2 ELISA试剂盒)-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined.
Data (including data from studies using cells from knockout mice) suggest that CLEC2 (显示 CLEC1B ELISA试剂盒)/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 (显示 CLEC1B ELISA试剂盒) = C-type lectin (显示 MBL2 ELISA试剂盒) CLEC2 (显示 CLEC1B ELISA试剂盒); CLEC2R = CLEC2 (显示 CLEC1B ELISA试剂盒) receptor; GNAQ = guanine nucleotide-binding protein (显示 COASY ELISA试剂盒) G[q] subunit alpha)
The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b (显示 CCR2 ELISA试剂盒)-stimulated Rho A (显示 RHOA ELISA试剂盒) GTPase (显示 RACGAP1 ELISA试剂盒)-mediated serum response factor activation.
GNAQ/11 mutant clones make up a fraction of the cells in choroidal nevi. Nevus cells are furthermore characterised by heterogeneous YAP (显示 YAP1 ELISA试剂盒) expression. Combined GNAQ/11 and YAP (显示 YAP1 ELISA试剂盒) may constitute a putative precursor tumour pathway with an activated oncogene (显示 RAB1A ELISA试剂盒) (GNAQ/11) and downstream effector (YAP (显示 YAP1 ELISA试剂盒)).
RasGRP3 (显示 RASGRP3 ELISA试剂盒) mediates ERK MAPK (显示 MAPK1 ELISA试剂盒) pathway activation in GNAQ mutant uveal melanoma.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (显示 TH1L ELISA试剂盒) differentiation
The GC/GC (显示 GC ELISA试剂盒) genotype of the TT(-695/-694)GC polymorphism is associated with increased Gq protein expression, augmented angiotensin II receptor type 1 (显示 AGTR1 ELISA试剂盒)-related vasoconstriction, and increased myocardial injury after coronary artery bypass grafting.
The Galphas (显示 GNAS ELISA试剂盒) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (显示 AVPR1A ELISA试剂盒), respectively. The beta2-AR/Galphas (显示 GNAS ELISA试剂盒) peptide interface is dominated by electrostatic interactions, whereas the V1AR (显示 AVPR1A ELISA试剂盒)/Galphaq peptide interactions are predominantly hydrophobic.
The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.
atomic structure of GRK2 (显示 ADRBK1 ELISA试剂盒) in complex with Galphaq and Gbetagamma, in which the activated Galpha (显示 SUCLG1 ELISA试剂盒) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (显示 TGFB1 ELISA试剂盒) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (显示 IL33 ELISA试剂盒) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the impaired working memory in forebrain-specific Perk (显示 EIF2AK3 ELISA试剂盒) knockout mice may stem from altered Gq protein-coupled intracellular Ca(2 (显示 CA2 ELISA试剂盒)+) dynamics in cortical pyramidal neurons.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (显示 HAND1 ELISA试剂盒) differentiation
Fluid shear stress acts on the Galphaq-ERK5 (显示 MAPK7 ELISA试剂盒) signaling pathway to upregulate Cyclin B1 (显示 CCNB1 ELISA试剂盒) and CDK1 (显示 CDK1 ELISA试剂盒) expression, thereby resulting in MC3T3-E1 cell proliferation.
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (显示 CRH ELISA试剂盒) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
The betaARKrgs peptide, but not endogenous GRK2 (显示 ADRBK1 ELISA试剂盒), interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2 (显示 ADRBK1 ELISA试剂盒)-based therapeutic approaches to prevent hypertrophy and heart failure.
Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
, guanine nucleotide-binding protein G(q) subunit alpha
, guanine nucleotide-binding protein alpha-q
, G alpha q
, guanine nucleotide binding protein alpha q subunit
, guanine nucleotide binding protein, alpha q polypeptide
, guanine nucleotide regulatory protein G alpha q
, heterotrimeric guanine nucleotide-binding protein alpha q subunit
, guanine nucleotide-binding protein G(q) alpha subunit