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抗Human GNAQ 抗体:
抗Rat (Rattus) GNAQ 抗体:
抗Mouse (Murine) GNAQ 抗体:
Chicken Monoclonal GNAQ Primary Antibody for IF, WB - ABIN968914
Dutt, Kjoller, Giel, Hall, Toksoz: Activated Galphaq family members induce Rho GTPase activation and Rho-dependent actin filament assembly. in FEBS letters 2002
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Chicken Monoclonal GNAQ Primary Antibody for IF, WB - ABIN968915
Li, Iyengar: Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal GNAQ Primary Antibody for ELISA, WB - ABIN4315225
Ngai, Inngjerdingen, Berge, Taskén: Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. in BMC immunology 2009
Human Monoclonal GNAQ Primary Antibody for ELISA, WB - ABIN516106
Sánchez-Fernández, Cabezudo, Caballero, García-Hoz, Tall, Klett, Michnick, Mayor, Ribas: Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector. in The Journal of biological chemistry 2016
Phospholipase C beta connects G protein signaling with RNA interference. (Review)
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (显示 SOX10 抗体) expression and presence of the BRAF (显示 BRAF 抗体) V600E mutation.
Mutations in GNAQ and GNA11 (显示 GNA11 抗体) genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
These results indicate that the mechanism by which Galphaq and PLC (显示 HSPG2 抗体)-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined.
Data (including data from studies using cells from knockout mice) suggest that CLEC2 (显示 CLEC1B 抗体)/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ agonists. (CLEC2 (显示 CLEC1B 抗体) = C-type lectin (显示 MBL2 抗体) CLEC2 (显示 CLEC1B 抗体); CLEC2R = CLEC2 (显示 CLEC1B 抗体) receptor; GNAQ = guanine nucleotide-binding protein (显示 COASY 抗体) G[q] subunit alpha)
The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b (显示 CCR2 抗体)-stimulated Rho A (显示 RHOA 抗体) GTPase (显示 RACGAP1 抗体)-mediated serum response factor activation.
GNAQ/11 mutant clones make up a fraction of the cells in choroidal nevi. Nevus cells are furthermore characterised by heterogeneous YAP (显示 YAP1 抗体) expression. Combined GNAQ/11 and YAP (显示 YAP1 抗体) may constitute a putative precursor tumour pathway with an activated oncogene (显示 RAB1A 抗体) (GNAQ/11) and downstream effector (YAP (显示 YAP1 抗体)).
RasGRP3 (显示 RASGRP3 抗体) mediates ERK MAPK (显示 MAPK1 抗体) pathway activation in GNAQ mutant uveal melanoma.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (显示 TH1L 抗体) differentiation
The GC/GC (显示 GC 抗体) genotype of the TT(-695/-694)GC polymorphism is associated with increased Gq protein expression, augmented angiotensin II receptor type 1 (显示 AGTR1 抗体)-related vasoconstriction, and increased myocardial injury after coronary artery bypass grafting.
The Galphas (显示 GNAS 抗体) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (显示 AVPR1A 抗体), respectively. The beta2-AR/Galphas (显示 GNAS 抗体) peptide interface is dominated by electrostatic interactions, whereas the V1AR (显示 AVPR1A 抗体)/Galphaq peptide interactions are predominantly hydrophobic.
The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.
atomic structure of GRK2 (显示 ADRBK1 抗体) in complex with Galphaq and Gbetagamma, in which the activated Galpha (显示 SUCLG1 抗体) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]
the impaired working memory in forebrain-specific Perk (显示 EIF2AK3 抗体) knockout mice may stem from altered Gq protein-coupled intracellular Ca(2 (显示 CA2 抗体)+) dynamics in cortical pyramidal neurons.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (显示 HAND1 抗体) differentiation
Fluid shear stress acts on the Galphaq-ERK5 (显示 MAPK7 抗体) signaling pathway to upregulate Cyclin B1 (显示 CCNB1 抗体) and CDK1 (显示 CDK1 抗体) expression, thereby resulting in MC3T3-E1 cell proliferation.
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (显示 CRH 抗体) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
The betaARKrgs peptide, but not endogenous GRK2 (显示 ADRBK1 抗体), interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2 (显示 ADRBK1 抗体)-based therapeutic approaches to prevent hypertrophy and heart failure.
Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling.
Developmental AHR activation by pollutants, and other exogenous ligands, increases the likelihood that Gnaq knockout mice will develop autoimmune diseases later in life.
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
, guanine nucleotide-binding protein G(q) subunit alpha
, guanine nucleotide-binding protein alpha-q
, G alpha q
, guanine nucleotide binding protein alpha q subunit
, guanine nucleotide binding protein, alpha q polypeptide
, guanine nucleotide regulatory protein G alpha q
, heterotrimeric guanine nucleotide-binding protein alpha q subunit
, guanine nucleotide-binding protein G(q) alpha subunit