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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN2017902
Djalilian, Caicedo, Lessan, Grami, Le, Spellman, Pambuccian, Hall, Low, Ondrey: Efficacy of an osmotic pump delivered, GM-CSF-based tumor vaccine in the treatment of upper aerodigestive squamous cell carcinoma in rats. in Cancer immunology, immunotherapy : CII 2007
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803898
Carreño, Pacheco, Gutierrez, Jacobelli, Kalergis: Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells. in Immunology 2010
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Mouse (Murine) CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803901
Bråve, Ljungberg, Boberg, Rollman, Isaguliants, Lundgren, Blomberg, Hinkula, Wahren: Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery. in Molecular therapy : the journal of the American Society of Gene Therapy 2005
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN934919
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
TRAF6 (显示 TRAF6 蛋白) is also required for GM-CSF-induced ubiquitination and activation of Akt (显示 AKT1 蛋白).
High GM-CSF expression is associated with breast Cancer.
In gastric cancer (GC), tumour-derived GM-CSF activated neutrophils and induced neutrophil PD-L1 (显示 CD274 蛋白) expression via Janus kinase (JAK (显示 JAK3 蛋白))-signal transducer and activator of transcription 3 (STAT3 (显示 STAT3 蛋白)) signalling pathway. The activated PD-L1 (显示 CD274 蛋白)(+) neutrophils effectively suppressed normal T-cell immunity in vitro and contributed to the growth and progression of human GC in vivo.
The IL-3 (显示 IL-3 蛋白)/ GM-CSF effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs).
Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 (显示 IL5 蛋白) and GM-CSF.
Data suggest that the methylotrophic yeast Pichia pastoris is an effective recombinant host for heterologous granulocyte-macrophage colony-stimulating factor (rhGM-CSF) production.
Letter: Knockdown of either filaggrin (显示 FLG 蛋白) or loricrin (显示 LOR 蛋白) increases the productions of interleukin (IL)-1alpha, IL-8 (显示 IL8 蛋白), IL-18 (显示 IL18 蛋白) and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.
Impaired RASGRF1 (显示 RASGRF1 蛋白)/ERK (显示 EPHB2 蛋白)-mediated GM-CSF response characterizes CARD9 (显示 CARD9 蛋白) deficiency in French-Canadians.
Honokiol could possess potential anti-inflammatory effects and inhibits TNF-alpha (显示 TNF 蛋白)-induced IL-1beta (显示 IL1B 蛋白), GM-CSF and IL-8 (显示 IL8 蛋白) production in PBMCs from rheumatoid arthritis patients.
The canonical NFkappaB (显示 NFKB1 蛋白) signaling in fibroblasts, but not in tumor cells, was shown to be responsible for the induced and constitutive CSF2 expression.
GM-CSF primes IL-13 (显示 IL13 蛋白) production by macrophages via PAR-2 (显示 F2RL1 蛋白).
These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 (显示 CXCL10 蛋白) and GM-CSF gene transcription.
Data suggest exposure to maternal CSF2 from D5-D7 of development is fundamentally different for female/male blastocysts with respect to embryo elongation, characteristics of transcriptome/methylome, and endometrial interferon tau secretion at D15 (显示 MRPL16 蛋白).
The increase in calving rate caused by CSF2 treatment involves, in part, more extensive development of extraembryonic membranes and capacity of the conceptus to secrete IFNT2 at day 15 of pregnancy.
immunolocalization studies confirmed the presence of granulocyte-macrophage colony stimulating factor(GM-CSF) in the germ cell line in bovine and human testes and addition of GM-CSF enhances several parameters of sperm motility
the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 (显示 PTGS2 蛋白) and GM-CSF during the peri (显示 PLIN1 蛋白)-attachment period in the cow.
CSF2 affect embryonic development and enhance embryo competence for posttransfer survival.
GM-CSF is required for the normal balance of leukocyte subsets, including granulocytes, B cells, and naive vs. effector T cells. There was an approximately 3-fold increase in the percentages of granulocytes in Csf2-/- PBMCs. The presence of maximal experimental autoimmune encephalomyelitis in the complete absence of GM-CSF revealed that GM-CSF is not an obligate effector molecule in all forms of EAE.
chemerin (显示 RARRES2 蛋白) inhibited nuclear factor-kappaB activation and the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (显示 IL2 蛋白) (IL-6 (显示 IL6 蛋白)) by tumor cells and tumor-associated endothelial cell, respectively, via its receptors, and consequently, MDSC induction was impaired, leading to restoration of antitumor T-cell response and decreased tumor angiogenesis.
These findings describe a novel role for GM-CSF as an essential initiating cytokine in cardiac inflammation.
Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF (显示 CSF3 蛋白) and/or GM-CSF (G(M)-CSF (显示 CSF1R 蛋白)) synthesized by the brain. Glioblastoma cells themselves also synthesize G(M)-CSF (显示 CSF1R 蛋白). G(M)-CSF (显示 CSF1R 蛋白) synthesized by brain due to damage by a growing tumor and by the tumor itself stimulates bone marrow to shift hematopoiesis toward granulocytic lineages away from lymphocytic lineages.
Evi1 (显示 MECOM 蛋白)(+)DA-3 cells modified to express an intracellular form of GM-CSF, acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF levels.
IL-23 (显示 IL23A 蛋白)-induced GM-CSF mediates the pathogenicity of CD4 (显示 CD4 蛋白)(+) T cells in experimental autoimmune myocarditis.
GM-CSF accelerated the G1/S phase transition in EPCs by upregulating the expression of cyclins D1 and E.
Proteomic Analysis Reveals Distinct Metabolic Differences Between Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Macrophage Colony Stimulating Factor (M-CSF (显示 CSF1R 蛋白)) Grown Macrophages Derived from Murine Bone Marrow Cells
host RNF13 (显示 RNF13 蛋白) affects the concentration of GM-CSF in tumor-bearing lungs
CSF2 stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (显示 MAPK1 蛋白)-dependent MTOR (显示 FRAP1 蛋白) signal transduction cascades.
Data indicate that differentially expressed IL-17 (显示 IL17A 蛋白), IL-22 (显示 IL22 蛋白), and IL-23 (显示 IL23A 蛋白) levels are associated with K-ras (显示 HRAS 蛋白) in a stage-specific fashion along colorectal cancer progression and an association was established between mutant K-ras (显示 HRAS 蛋白) and GM-CSF and IFN-gamma (显示 IFNG 蛋白).
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.
granulocyte-macrophage colony-stimulating factor
, colony stimulating factor 2 (granulocyte-macrophage)
, colony-stimulating factor
, granulocyte-macrophage colony stimulating factor 2
, put. GM-CSF
, granulate-macrophage stimulating factor
, granulocyte-macrophage stimulation factor