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results highlight the importance of HTR1 in leukemogenesis and LSC (显示 ARHGEF1 蛋白) survival and identify this receptor family as a new target for therapy in AML (显示 RUNX1 蛋白) with prognostic value
HTR (显示 F2R 蛋白) polymorphisms related to vulnerability to major depressive disorder (MDD) and MDD with suicidal attempts.
The results of this study give new evidence for the role of epigenetic and genetic factors which could modulate HTR1B expression in the pharmacological response to antidepressants.
5-HT1B receptor-dependent cellular Src (显示 SRC 蛋白)-related kinase-Nox1 (显示 NOX1 蛋白)-pathways contribute to vascular remodeling in pulmonary arterial hypertension.
preliminary findings suggest a role of the HTR1B gene in susceptibility to development of bulimia nervosa subtypes. Furthermore, this gene might have an impact on the severity of anxiety in anorexia nervosa-spectrum patients.
Polymorphic variants of the HTR1B gene are associated with the susceptibility of secondary RP in vibration-exposed occupational populations of Chinese Han people.
large scale neural activation differences in the inferior and medial frontal and temporal/parietal regions of the response inhibition network between the different variants of both the HTR1B and 5HTT (显示 SLC6A4 蛋白) genes; activation in these regions was significantly associated with stop-task performance, but not with ADHD diagnosis or severity
Results from Parkinson's disease patients and MPTP (显示 PTPN2 蛋白)-lesioned monkeys argue in favor of a contribution of 5-HT1B receptors in the pathophysiology of levodopa-induced motor complications
The interaction between two major serotonergic structures involved in serotonin release, the SERT (显示 SLC6A4 蛋白) and 5-HT1B receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-HT1A (显示 HTR1A 蛋白) receptors.
Serotonin 1B Receptor Gene (HTR1B) Methylation as a Risk Factor for Callous-Unemotional Traits in Antisocial Boys
The data show for the first time an important interactive relationship between SERT (显示 SLC6A4 蛋白) and the PDGFRbeta in the production of pulmonary artery smooth muscle cell proliferation triggered by PDGF (显示 PDGFA 蛋白).
analysis of eight bovine 5-HT receptor subtypes in brain, abomasum, and intestine by real-time RT-PCR
Combinational action of SERT (显示 SLC6A4 蛋白) and a 5-HT receptor in SMC (显示 DYM 蛋白) growth and Rho A (显示 RHOA 蛋白)/ROCK participation in 5-HT receptor 1B/1D-mediated mitogenesis of vascular SMCs through an effect on cytoplasmic to nuclear translocation of ERK1 (显示 MAPK3 蛋白)/ERK2 (显示 MAPK1 蛋白).
The relationship between polymorphisms at the HTR1B site and milk yield in Holstein cattle is reported.
vestibular ganglion cells were immunoreactive for 5-HT(1B) receptors in macaques and rats.
found high levels of serotonin receptor 1B mRNA in primary visual cortex (V1) and clear activity-dependent modulatory effects of 5-HT1B receptor agonists on responses of V1 neurons.
Consistent with previous studies that have optogenetically inhibited vHPC-mPFC projections, activating prefrontal 5-HT1B receptors suppressed theta-frequency mPFC activity (4-12 Hz), and reduced avoidance of anxiogenic regions in the elevated plus maze
we showed that gravity changes induced differential modulation of gene expression of BDNF (显示 BDNF 蛋白) and 5-HTRs (5-HT1AR, 5-HT1BR and 5-HT2AR) in some brain regions. The modulation of gene expression may constitute molecular bases that underlie behavioral alteration induced by gravity changes.
Mice lacking 5-HT1B autoreceptors displayed the expected increases in extracellular serotonin levels in the ventral hippocampus following administration of a selective serotonin reuptake inhibitor.
Data suggest that pharmacological stimulation of serotonin 5Ht1b receptor enhances up-regulation of plasma Glp1 (glucagon-like peptide 1 (显示 GCG 蛋白)) induced by Dpp4 (dipeptidylpeptidase 4 (显示 DPP4 蛋白)) inhibition independently of feeding and also improves glucose tolerance.
5-HT1B Knockout and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in dopamine transporter Knockout mice.
The data of this study showed that while adolescent expression of 5-HT1BRs influences aggressive behavior, a distinct set of 5-HT1B receptors modulates impulsive behavior during adulthood.
The serotoninergic system plays an important role in the regulation of stress-induced depigmentation, which can be mediated by 5-HT1A (显示 HTR1A 蛋白)/1B receptors.
5-HT(1B)R stimulation increased glutamatergic neurotransmission in the hippocampus in p11KO mice, but not in WT mice. Hippocampal p11 (显示 S100A10 蛋白) determines the directionality of 5-HT(1B)R action on emotional memory processing
Selective inhibition of 5-HT2A by sarpogrelate stimulated angiogenesis, restoring ischemic limb blood perfusion in a severe diabetic mouse model through stimulation of the eNOS (显示 NOS3 蛋白)/Akt (显示 AKT1 蛋白) pathway via the endothelial 5-HT1B receptor.
The neurotransmitter serotonin (5-hydroxytryptamine\; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992
, 5-hydroxytryptamine receptor 1B
, serotonin 1D beta receptor
, serotonin receptor 1B
, 5-hydroxytryptamine serotonin receptor 1B
, 5-hydroxytryptamine 1B receptor
, 5-HT1D beta receptor
, 5-HT1D beta
, 5-HT1D subtype beta
, 5-Hydroxytryptamine 1D receptor subtype beta
, 5-hydroxytryptamine (serotonin) receptor 1B
, 5-HT1B receptor
, 5-HT<1B> receptor
, 5-HT1B serotonin receptor
, 5-hydroxytryptamine (serotonin ) receptor 1B
, serotonin (5-hydroxytryptamine (5HT)) receptor type 1B
, drosophila serotonin receptor 1B
, serotonin receptor 2B
, 5-hydroxytryptamine receptor 1B-like
, Serotonin receptor 1B