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SMN1 抗体

(Survival of Motor Neuron 1, Telomeric (SMN1))
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy\; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008].
SMN1 抗体 SMN1 抗体 SMN1 抗体 (ABIN969408)

SMN1 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 5H1 unconjugated

SMN1 抗体 SMN1 抗体 SMN1 抗体 (ABIN969407)

SMN1 适用: 人, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2F1 unconjugated

SMN1 抗体  (AA 80-150) SMN1 抗体  (AA 80-150) SMN1 抗体 (AA 80-150) (ABIN7270652)

SMN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

SMN1 抗体 by 适用

Find SMN1 抗体 for a variety of species such as anti-Human SMN1, anti-Mouse SMN1, anti-Rat SMN1. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find SMN1 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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SMN1 抗体 by 抗原表位

Find SMN1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

SMN1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal SMN1 抗体. Click on a link to go to the corresponding products.

SMN1 抗体 by 克隆

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Find SMN1 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular SMN1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Monkey
Application WB, ELISA, IHC, ICC
Validations
  • (1)
  • (5)
Cat. No. ABIN969408
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, ELISA, IHC, FACS
Validations
  • (1)
  • (4)
Cat. No. ABIN969407
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN7270652
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB
Validations
  • (5)
Cat. No. ABIN2778671
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7171024
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN524429
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Xenopus laevis
Application WB, ELISA, IP, IF, IHC (p), ICC, FACS
Validations
  • (2)
  • (2)
Cat. No. ABIN108566
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN7270651
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, ICC
Validations
  • (1)
  • (2)
Cat. No. ABIN2854909
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7443548
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP
Validations
  • (1)
  • (1)
Cat. No. ABIN541049
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog, Human, Monkey, Mouse
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6747045
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN6568829
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7001502
Quantity 20 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN6265189
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our SMN1 抗体

Zhang, Lin, Li, Lu, Guo, Dong, Zhao, He, Wang, Chen: "Application of urine cells in drug intervention for spinal muscular atrophy." in: Experimental and therapeutic medicine, Vol. 14, Issue 3, pp. 1993-1998, (2017) (PubMed).

Hendrickson, Donohoe, Akmaev, Sugarman, Labrousse, Boguslavskiy, Flynn, Rohlfs, Walker, Allitto, Sears, Scholl: "Differences in SMN1 allele frequencies among ethnic groups within North America." in: Journal of medical genetics, Vol. 46, Issue 9, pp. 641-4, (2009) (PubMed).

Ogawa, Usui, Aoki, Ito, Itoh, Kai, Kanamori-Katayama, Hayashizaki, Suzuki: "Gemin2 plays an important role in stabilizing the survival of motor neuron complex." in: The Journal of biological chemistry, Vol. 282, Issue 15, pp. 11122-34, (2007) (PubMed).

Grondard, Biondi, Armand, Lécolle, Della Gaspera, Pariset, Li, Gallien, Vidal, Chanoine, Charbonnier: "Regular exercise prolongs survival in a type 2 spinal muscular atrophy model mouse." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 33, pp. 7615-22, (2005) (PubMed).

Liu, Dreyfuss: "A novel nuclear structure containing the survival of motor neurons protein." in: The EMBO journal, Vol. 15, Issue 14, pp. 3555-65, (1996) (PubMed).

Aliases for SMN1 抗体

survival motor neuron protein (LOC461829) 抗体
survival of motor neuron 1, telomeric (Smn1) 抗体
survival of motor neuron 1, telomeric (SMN1) 抗体
survival motor neuron 1 (Smn1) 抗体
survival of motor neuron 2, centromeric (SMN2) 抗体
survival motor neuron protein-like (LOC100348318) 抗体
survival motor neuron (SMN) 抗体
survival motor neuron protein (LOC100713418) 抗体
survival motor neuron protein (LOC100065744) 抗体
survival motor neuron protein (LOC102176643) 抗体
survival of motor neuron 1, telomeric (smn1) 抗体
AI849087 抗体
BCD541 抗体
fa12d01 抗体
GEMIN1 抗体
Gemin1 抗体
QtsA-10002 抗体
SMA 抗体
SMA1 抗体
SMA2 抗体
SMA3 抗体
SMA4 抗体
SMA@ 抗体
Smn 抗体
SMN 抗体
smn 抗体
SMN1 抗体
SMN2 抗体
SMNT 抗体
T-BCD541 抗体
TDRD16A 抗体
wu:fa12d01 抗体
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