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These findings illustrate a novel strategy for viral interference with the SUMO pathway, and identify the EBV miR (显示 MLXIP ELISA试剂盒)-BHRF1-1 and the cellular RNF4 as regulators of the productive virus cycle.
These results point to an important role of the affinity between RNF4 and its cognate RAD6B (显示 UBE2B ELISA试剂盒) or UBCH5B (显示 UBE2D2 ELISA试剂盒) in governing the multiplicity of substrate ubiquitination.
the opposing activities of RNF4 and ataxin-3 (显示 ATXN3 ELISA试剂盒) consolidate robust MDC1 (显示 MDC1 ELISA试剂盒)-dependent signaling and repair ofDNA double-strand break.
Combined effect of dynamic recruitment of RNF4 to KAP1 regulates the relative occupancy of 53BP1 and BRCA1 at double-strand break sites to direct DNA repair in a cell cycle-dependent manner.
c-Myc (显示 MYC ELISA试剂盒) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1 (显示 PIAS1 ELISA试剂盒), SENP7 (显示 SENP7 ELISA试剂盒) and RNF4
Data show that RNF4 is a SUMO-targeted ubiquitin ligase that targets TRF2 (显示 TERF2 ELISA试剂盒) for ubiquitination.
novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 (显示 USP11 ELISA试剂盒) and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR (显示 DDR1 ELISA试剂盒).
RNF4 negatively regulates NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling by down-regulating TAB2 (显示 TAB2 ELISA试剂盒)
RNF4 enhances Ube2E1 (显示 UBE2E1 ELISA试剂盒) self-ubiquitination.
NMR spectroscopy and biochemical characterization reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer.
These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure.
This paper identifies a nucleosome-targeting motif within the RNF4 RING domain that can bind DNA and thereby enables RNF4 to selectively ubiquitinate nucleosomal histones.
fork collapse in Atr (显示 ATR ELISA试剂盒)-deleted cells is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA (显示 AURKA ELISA试剂盒)-PLK1 (显示 PLK1 ELISA试剂盒) pathway
Rnf4 controls protein localization at DNA damage sites by integrating SUMOylation and ubiquitylation events.
SUMO interacting motif is dispensable for PML (显示 PML ELISA试剂盒) SUMOylation and interaction with RNF4 but is required for efficient PML (显示 PML ELISA试剂盒) ubiquitination, recruitment of proteasome components within NBs (显示 NLRP2 ELISA试剂盒) and proteasome-dependent degradation of PML (显示 PML ELISA试剂盒) in response to AsO
Rnf4 deficiency is embryonic lethal with higher levels of methylation in genomic DNA. Mechanistic studies show that RNF4 interacts with and requires the base excision repair enzymes TDG (显示 TDG ELISA试剂盒) and APE1 (显示 APEX1 ELISA试剂盒) for active demethylation.
GC-rich (显示 RELB ELISA试剂盒) elements flanking the transcription start site govern activation
1.6- and 3.0-kb transcripts originate from the same promoter, encode for the same protein and differ in the 3' UTR (显示 UTS2R ELISA试剂盒).
RNF4 is a negative regulator of TRPS1 (显示 TRPS1 ELISA试剂盒) activity
results suggest a role for small nuclear ring finger protein(SNURF/RNF4) in fetal germ cell development as well as in oocyte and granulosa cell maturation in an estrogen- and gonadotropin-regulated fashion
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
E3 ubiquitin ligase RNF4
, E3 ubiquitin-protein ligase RNF4
, small nuclear RING finger protein
, gene trap ROSA b-geo 8
, small nuclear ring finger protein
, RING finger protein 4