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The involvement of mTOR (显示 FRAP1 ELISA试剂盒)-PGC-1alpha pathway in the connection between FTO (显示 FTO ELISA试剂盒) and muscle differentiation is displayed.
findings indicate that exercise intensity affected autophagy markers differently in skeletal muscle and suggest that PGC-1alpha regulates both acute and exercise training-induced autophagy in skeletal muscle potentially in a PGC-1alpha isoform specific manner
EET-mediated increase in HO-1 (显示 HMOX1 ELISA试剂盒) levels require PGC-1alpha expression
This change in the cellular location of p53 (显示 TP53 ELISA试剂盒) alleviates the abrogation of PGC (显示 PGC ELISA试剂盒)-1a repression caused by nuclear p53 (显示 TP53 ELISA试剂盒), which may further increases PGC (显示 PGC ELISA试剂盒)-1a expression
Peroxisome proliferator-activated receptor gamma (显示 PPARG ELISA试剂盒) coactivator 1alpha (PGC-1alpha) exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1alpha in different models of muscle wasting.
Adult conditional PGC-1alpha knock-out mice show a significant loss of dopaminergic neurons th (显示 EPRS ELISA试剂盒)at is accompanied by a reduction of dopamine in the striatum. Study identifies also two brain-enriched isoforms of PGC-1alpha: PGC-1alpha1L (160 kDa) and PGC-1alpha1S (100 kDa).
The study propose that gluconeogenesis driven by NTPGC- 1a, along with PGC (显示 PGC ELISA试剂盒)-1a, contributes to the elevated blood glucose level in response to fasting.
Metagenomic analysis revealed direct correlation between PPARGC1A, SNAI1 (显示 SNAI1 ELISA试剂盒), and metastatic lung disease.
Destabilization of PGC1a is attributable to decreased p38 MAPK (显示 MAPK14 ELISA试剂盒) activation via diminished CaMKII (显示 CAMK2G ELISA试剂盒) signaling. Thus, we elucidate a pathway downstream of Ca(2 (显示 CA2 ELISA试剂盒)+)-mediated CaMKII (显示 CAMK2G ELISA试剂盒) activation that is dysfunctional in C3KO(Capn3 (显示 CAPN3 ELISA试剂盒) knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation
lncBATE10 can decoy Celf1 (显示 CELF1 ELISA试剂盒) from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1 (显示 CELF1 ELISA试剂盒)
Study investigated the molecular basis of such effects focusing on a commonly studied polymorphism in pig Pgc1alpha, which changes a cysteine at position 430 (WT) of the protein to a serine (C430S); found that differential O-GlcNAcylation of Pgc1alpha regulates PCK1 (显示 PCK1 ELISA试剂盒) activity and this molecular mechanism could explain at least in part the epistatic interaction between both genes.
Transcription of the gene was detected in adipose, muscle, kidney, liver, brain, heart and adrenal gland tissues, which is in agreement with the function of PPARGC1A in adaptive thermogenesis.
The purpose of this study was to screen for new single nucleotide polymorphisms in exon 8 of the porcine PPARGC1A gene and to test their possible association with production traits.
impact of PPARGC1A on energy and lipid metabolism in vivo, through several downstream target genes
The *2690T>C and *2864T>C polymorphisms in PPARGC1A can be used as genetic markers for selection toward improved meat quality.
The c.-2894G>A polymorphism in the 5' upstream region of the porcine PPARGC1A gene can be used as a meaningful molecular marker for simultaneous improvement of lean meat production and quality traits.
PPARGC1A may play a key role in down-regulating lipid deposition, and the SNPs with differential genotype distribution among three breeds may be related to gene expression and fat deposition.
Polymorphisms in PPARGC1A and CAPNS1 (显示 CAPNS1 ELISA试剂盒) genes may affect meat quality traits.
skeletal muscle PGC-1alpha is required for fasting-induced (显示 C10orf10 ELISA试剂盒) upregulation of skeletal muscle SIRT3 (显示 SIRT3 ELISA试剂盒) and maintaining high fat oxidation in the fasted state, but is dispensable for preserving the capability to switch substrate during the transition from the fed to the fasted state and for fasting-induced (显示 C10orf10 ELISA试剂盒) PDH (显示 PDP ELISA试剂盒) regulation in skeletal muscle.
Conversely, nitric oxide (NO) triggered post translation modifications of PGC-1alpha and induced FAO, recovering the bioenergetics impairment of muscles but shunting the defective mitochondrial biogenesis.
The results revealed that the distribution of genotypes and allele frequency of the PGC-1alpha Gly482Ser polymorphism in polycystic ovary syndrome patients was statistically significant from those of the control group respectively indicating that the presence of 'A' allele might confer risk to polycystic ovary syndrome.
PGC-1alpha protein was higher after HIHVT than after SIT (p < 0.05). Moreover, the AMPKpTHR172/AMPK (显示 PRKAA1 ELISA试剂盒) ratio increased at post after SIT (p < 0.05), whereas this effect was delayed after HIHVT as it increased after 3 h
There were no significant correlations between LRP130 (显示 LRPPRC ELISA试剂盒), SIRT3 (显示 SIRT3 ELISA试剂盒), or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130 (显示 LRPPRC ELISA试剂盒), SIRT3 (显示 SIRT3 ELISA试剂盒), and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.
Study found that in human Parkinson's disease postmortem tissue from the substantia nigra pars (显示 EPRS ELISA试剂盒) compacta, there is a reduction of PGC-1alpha isoforms and mitochondria markers.
type 2 diabetes mellitus is associated with decreased expression of PGC1alpha and UCP1 (显示 UCP1 ELISA试剂盒) mRNA in epicardial adipose tissue of patients with coronary artery disease.
These studies suggest SIRT1 (显示 SIRT1 ELISA试剂盒)/PGC-1alpha as underlying pathways contributing to AMD (显示 AMD1 ELISA试剂盒) pathophysiology.
Low-intensity endurance cycling exercise performed with blood flow restriction failed to increase PGC-1alpha expression to that commonly observed with endurance exercise. Isoform-specific postexercise increases in the alpha4 isoform along with Hif-1alpha and VEGF mRNA expression following higher intensity endurance exercise without blood flow restriction.
PPARGC1A single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age.
PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits.
NO/protein kinase (显示 CDK7 ELISA试剂盒) G (PKG (显示 PRKG1 ELISA试剂盒))-dependent downregulation of PGC-1 alpha and the ROS (显示 ROS1 ELISA试剂盒) detoxification system in endothelial cells are mediated by the PI3K/Akt (显示 AKT1 ELISA试剂盒) signaling
The effects of dietary fat components on the expression of PPAR-gamma (显示 PPARG ELISA试剂盒) AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.
genetic analysis of bovine PPARGC1A
PPARGC1A was associated with a significant increase in milk protein (显示 CSN2 ELISA试剂盒) percentage in contrast to association results previously reported for the German Holstein population
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
, PPAR-gamma coactivator
, peroxisome proliferator activated receptor gamma coactivator-1
, PPAR Gamma Coactivator-1
, PPAR gamma coactivator variant form
, PPAR-gamma coactivator 1-alpha
, peroxisome proliferator-activated receptor gamma coactivator 1-alpha
, ligand effect modulator-6
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5
, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT
, peroxisome proliferative activated receptor, gamma, coactivator 1
, peroxisome proliferator activated receptor gamma coactivator 1 alpha
, peroxisome proliferative activated receptor gamma coactivator 1
, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
, proliferator-activated receptor gamma coactivator 1 alpha
, peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
, peroxisome-proliferator-activated receptor-gamma co-activator-1