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Human PARK7 ELISA Kit for Cell ELISA - ABIN2685152
Wang, Yu, Pu, Du: Baicalein prevents 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression. in Molecules (Basel, Switzerland) 2013
Melatonin, added together with MPTP or added once MPTP was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
chaperone-mediated autophagy protects mitochondrial function by degrading nonfunctional PARK7 and maintaining its homeostasis, and dysregulation of this pathway may contribute to the neuronal stress and death in Parkinson disease pathogenesis
Knockdown of DJ-1 attenuates Nurr1 (显示 NR4A2 ELISA试剂盒) activity.
These results demonstrate that DJ-1 KO mice display progressive signs of retinal/RPE degeneration in association with higher levels of oxidative stress markers. Collectively this analysis indicates that DJ-1 plays an important role in protecting photoreceptors and RPE from oxidative damage during aging
DJ-1 activates autophagy to alleviate cardiac hypertrophy.
These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.
DJ-1 is a powerful regulator of reactive oxygen species production as well as NHE1 (显示 SLC9A1 ELISA试剂盒) expression and activity in CD4 (显示 CD4 ELISA试剂盒)(+) T cells.
DJ-1 deficiency negatively regulates liver progenitor cells (LPC (显示 PCSK7 ELISA试剂盒)) proliferation by impairing the formation of LPC (显示 PCSK7 ELISA试剂盒)-associated fibrosis and inflammatory niches.
regulation of reactive oxygen species (ROS (显示 ROS1 ELISA试剂盒)) and of the antioxidant protein (显示 PRDX3 ELISA试剂盒) DJ-1 (PARK-7), which increases with cancer progression and acts to lessen oxidative damage to malignant cells, in relationship with systemic mastocytosis severity, was examined.
Our data strengthen previous findings regarding DJ-1 diverse pathways and indicate that DJ-1 is part of a concerted and complex cellular response to OS
Our data demonstrates that the activation of DJ-1 in response to myocardial I/R injury protects the heart by regulating the SUMOylation status of Drp1 (显示 CRMP1 ELISA试剂盒) and attenuating excessive mitochondrial fission.
DJ-1 and its prokaryotic homologs constitute a major nucleotide repair system named guanine glycation repair.
Taken together, our results provide a structural basis for the binding mechanism between DJ-1 and Bcl-XL (显示 BCL2L1 ELISA试剂盒), which will contribute to molecular understanding of the role of mitochondrial DJ-1 in Bcl-XL (显示 BCL2L1 ELISA试剂盒) regulation in response to oxidative stress.
Results suggest that overexpression of DJ-1 improves mitochondrial function, at least in part, through a mechanism involving Akt (显示 AKT1 ELISA试剂盒) phosphorylation on threonine 308.
Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are members of the DJ-1/ThiJ/PfpI superfamily.
DJ-1 co-aggregating with alpha-synuclein may result from weak hydrophobic interaction and DJ-1 exhibited chaperon-like activity in the initial time of alpha-synuclein aggregation at high temperature.
The effects of variants in the Parkin (显示 PARK2 ELISA试剂盒), PINK1, and DJ-1 genes along with evidence for their pathogenicity have been summarized. (Review)
genetic analyses of indel loci in ACE (显示 ACE ELISA试剂盒), DJ-1, and GIGYF2 (显示 GIGYF2 ELISA试剂盒) genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population.
Downregulation of DJ-1 using DJ-1-siRNA in H69AR cells sensitized cancer cells to chemotherapeutic drugs through increasing drug-induced cell apoptosis accompanied with G0-G1 phase arrest. These findings suggest DJ-1 may serve as a potential biomarker for chemoresistance and prognostic factor for patients with small-cell lung cancer (SCLC).
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22