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TRAP80 is a selective regulator of hepatic lipogenesis and is required for LXR (显示 NR1H3 ELISA试剂盒)-dependent SREBP-1c (显示 SREBF1 ELISA试剂盒) activation.
Studies indicate that the activation domain of p53 (显示 TP53 ELISA试剂盒) (p53AD) binds directly to the MED17 subunit of Mediator, whereas the p53 (显示 TP53 ELISA试剂盒) C-terminal domain (p53CTD) binds the MED1 (显示 MED1 ELISA试剂盒) subunit.
the p. L371P mutation in MED17 is a founder mutation in the Caucasus Jewish community and that homozygosity for this mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
mediator of RNA polymerase II transcription subunit 17
, Mediator of RNA polymerase II transcription subunit 17
, CRSP complex subunit 6
, cofactor required for Sp1 transcriptional activation subunit 6
, cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa
, activator-recruited cofactor 77 kDa component
, thyroid hormone receptor-associated protein complex 80 kDa component
, transcriptional coactivator CRSP77
, vitamin D3 receptor-interacting protein complex 80 kDa component
, cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
, cofactor required for Sp1 transcriptional activation, subunit 6