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PIKFYVE 抗体

(phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve\; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD)\; an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].
PIKFYVE 抗体  (AA 342-451) PIKFYVE 抗体  (AA 342-451) PIKFYVE 抗体 (AA 342-451) (ABIN566937)

PIKFYVE 适用: 人 ELISA, WB, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 6C7 unconjugated

PIKFYVE 抗体 PIKFYVE 抗体 PIKFYVE 抗体 (ABIN7011299)

PIKFYVE 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

PIKFYVE 抗体  (AA 1819-2098) PIKFYVE 抗体  (AA 1819-2098) PIKFYVE 抗体 (AA 1819-2098) (ABIN7142036)

PIKFYVE 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

PIKFYVE 抗体 by 适用

Find PIKFYVE 抗体 for a variety of species such as anti-Human PIKFYVE, anti-Mouse PIKFYVE, anti-Rat PIKFYVE. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find PIKFYVE 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

PIKFYVE 抗体 by 克隆形成能力

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Find PIKFYVE 抗体 with a specific conjugate such as Biotin, APC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular PIKFYVE 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IF, IHC (p), RNAi
Validations
  • (2)
  • (6)
Cat. No. ABIN566937
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7011299
Quantity 60 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7142036
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN566936
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7236083
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN391254
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IF
Validations
  • (1)
Cat. No. ABIN7188956
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN1327579
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, WB, IHC
Validations
  • (1)
Cat. No. ABIN6264230
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, ICC
Validations
  • (2)
Cat. No. ABIN1860221
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN1531726
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, WB, IF
Validations
  • (2)
Cat. No. ABIN1534208
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IF, IC
Validations
  • (2)
Cat. No. ABIN7303604
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN359341
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
Cat. No. ABIN7182416
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PIKFYVE 抗体

Takasuga, Horie, Sasaki, Sun-Wada, Kawamura, Iizuka, Mizuno, Eguchi, Kofuji, Kimura, Yamazaki, Horie, Odanaga, Sato, Chida, Kontani, Harada, Katada, Suzuki, Wada, Ohnishi, Sasaki: "Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1726-31, (2013) (PubMed).

Alesutan, Ureche, Laufer, Klaus, Zürn, Lindner, Strutz-Seebohm, Tavaré, Boehmer, Palmada, Lang, Seebohm, Lang: "Regulation of the glutamate transporter EAAT4 by PIKfyve." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 25, Issue 2-3, pp. 187-94, (2010) (PubMed).

Tsuruta, Green, Rousset, Dolmetsch: "PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death." in: The Journal of cell biology, Vol. 187, Issue 2, pp. 279-94, (2009) (PubMed).

Yang, Carpenter, Abrams: "Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 42331-6, (2004) (PubMed).

Sbrissa, Ikonomov, Strakova, Dondapati, Mlak, Deeb, Silver, Shisheva: "A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity." in: Molecular and cellular biology, Vol. 24, Issue 23, pp. 10437-47, (2004) (PubMed).

Ikonomov, Sbrissa, Mlak, Deeb, Fligger, Soans, Finley, Shisheva: "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50863-71, (2003) (PubMed).

Sbrissa, Ikonomov, Deeb, Shisheva: "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells." in: The Journal of biological chemistry, Vol. 277, Issue 49, pp. 47276-84, (2002) (PubMed).

Aliases for PIKFYVE 抗体

phosphoinositide kinase, FYVE finger containing (pikfyve) 抗体
phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE) 抗体
phosphoinositide kinase, FYVE type zinc finger containing (Pikfyve) 抗体
phosphoinositide kinase, FYVE-type zinc finger containing (Pikfyve) 抗体
5230400C17Rik 抗体
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