NEW: 请通过本地经销商订购 4A Biotech Co.,Ltd.

C646, p300/CBP Inhibitor

ABIN809530 产品详细信息, 供应商: Log in to see
应用范围
Blocking Reagent (BR), Inhibition Assay (InhA)
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

原理 A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor
产品特性 A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86 %) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (< 10 %). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.
纯度 ≥ 98 % by NMR
Chemical Name (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Formula C₂₄H₁₉N₃O₆
Permeability Cell-permeable
Solubility DMSO (25 mM)
分子量 445.42 g/mol
CAS-编号 328968-36-1
限制 仅限研究用
状态 Solid
注意事项 Protect from light and air
储存条件 -20 °C
有效期 36 months
厂商提供的图像
 image for C646, p300/CBP Inhibitor (ABIN809530) C646, p300/CBP Inhibitor
有引用在: Chen, Wang, Uttarwar, vanKrieken, Li, Chen, Gao, Ghayur, Margetts, Krepinsky: "SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells." in: Journal of molecular cell biology, Vol. 6, Issue 6, pp. 516-30, 2015 (PubMed).