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Calpain Inhibitor I, ALLN

ABIN629157 产品详细信息, 供应商: Log in to see
应用范围
Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A Calpain inhibitor
序列 Ac-Leu-Leu-Nile-CHO
产品特性 A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.
纯度 ≥ 95 % by HPLC
Chemical Name Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al
Formula C₂₀H₃₇N₃O₄
Permeability Cell-permeable
Solubility DMSO (25 mg/ml) or EtOH
分子量 383.54 g/mol
CAS-编号 110044-82-1
研究领域 Kinases/Phosphatases
限制 仅限研究用
状态 Powder
注意事项 Protect from moisture and air
储存条件 -20 °C
有效期 24 months
厂商提供的图像
 image for Calpain Inhibitor I, ALLN (ABIN629157) Calpain Inhibitor I, ALLN
有引用在: Cho, Yoon, Kim, Woo, Rhee: "Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 33, pp. 12043-8, 2014 (PubMed).