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IKK-ε Kinase Inhibitor II

ABIN629117 产品详细信息, 供应商: Log in to see
应用范围
Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 An IKK-ε kinase inhibitor
产品特性 A benzimidazole analog that acts as a potent and selective inhibitor of IKK-epsilon kinase (IC50 = 40 nM), displays >125-fold selectivity over IKK-alpha and IKK-beta.
纯度 ≥ 97 % by HPLC
Chemical Name 5-​(5,​6-​dimethoxy-​1H-​benzimidazol-​1-​yl)-​3-​[[2-​(methylsulfonyl)phenyl]methoxy]-​2-​thiophenecarbonitrile
Formula C₂₂H₁₉N₃O₅S₂
Permeability Cell-permeable
Solubility DMSO
分子量 469.53 g/mol
CAS-编号 862812-98-4
研究领域 Kinases/Phosphatases
限制 仅限研究用
状态 Solid
注意事项 Protect from air and light
储存条件 -20 °C
有效期 24 months
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有引用在: Palchetti, Starace, De Cesaris, Filippini, Ziparo, Riccioli: "Transfected poly(I:C) activates different dsRNA receptors, leading to apoptosis or immunoadjuvant response in androgen-independent prostate cancer cells." in: The Journal of biological chemistry, Vol. 290, Issue 9, pp. 5470-83, 2015 (PubMed).