Caspase-12 Inhibitor Z-ATAD-FMK

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应用范围
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A caspase-12 inhibitor
序列 Z-Ala-Thr-Ala-Asp(OMe)-FMK
产品特性 A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
纯度 > 95 % by HPLC
Chemical Name Z-ATAD-FMK, Caspase-12 Inhibitor, Z-ATAD-fluoromethylketone
Formula C₂₄H₃₃FN₄O₉
Permeability Cell-permeable
Solubility DMSO
分子量 540.54 g/mol
应用备注 We recommend using up to 1000-5000X dilutions for inhibiting caspase-12 activity in cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
限制 仅限研究用
状态 Liquid
浓度 10 mM
注意事项 Protect from light and moisture
储存条件 -20 °C
有效期 12 months
有引用在: Zeng, Li, He, Xu, Galicia, Deng, Stiles: "Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes." in: Molecular cancer research : MCR, Vol. 9, Issue 12, pp. 1708-17, 2011 (PubMed).

Bian, Elner, Elner: "Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role." in: Investigative ophthalmology & visual science, Vol. 49, Issue 12, pp. 5593-601, 2008 (PubMed).

Fu, Minamino, Tsukamoto, Sawada, Asai, Kato, Asano, Fujita, Takashima, Hori, Kitakaze: "Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition." in: Cardiovascular research, Vol. 79, Issue 4, pp. 600-10, 2008 (PubMed).

Ou, Wu, Ip, Meng, Hsu, Ip: "Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response." in: Journal of lipid research, Vol. 49, Issue 5, pp. 985-94, 2008 (PubMed).

Trisciuoglio, Uranchimeg, Cardellina, Meragelman, Matsunaga, Fusetani, Del Bufalo, Shoemaker, Melillo: "Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide." in: Journal of the National Cancer Institute, Vol. 100, Issue 17, pp. 1233-46, 2008 (PubMed).