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Caspase-6 Inhibitor Z-VEID-FMK

ABIN412349 产品详细信息, 供应商: Log in to see
应用范围
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A caspase-4 inhibitor
序列 Z-Val-E(OMe)-Ile-Asp(OMe)-FMK
产品特性 PubChem CID: 44135214
VEID is the specific recognition sequence for caspase-6/Mch2. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
纯度 > 98 % by HPLC
Chemical Name Z-VEID-FMK, Caspase-6 Inhibitor, VEID-FMK, VEID fluoromethylketone
Formula C₃₁H₄₅FN₄O₁₀
Permeability Cell-permeable
Solubility DMSO
分子量 652.9 g/mol
应用备注 We recommend using 1000-5000X dilutions for inhibiting caspase-6 activity in Jurkat cell culture (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
限制 仅限研究用
状态 Liquid
浓度 10 mM
注意事项 Protect from light and moisture
储存条件 -20 °C
有效期 6-12 months
有引用在: Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Pelizon, dAdda di Fagagna, Farrace, Laskey: "Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis." in: EMBO reports, Vol. 3, Issue 8, pp. 780-4, 2002 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).