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SCD1 Inhibitor

ABIN412321 产品详细信息, 供应商: Log in to see
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A SCD1(stearoyl-CoA desaturase 1 inhibitor
产品特性 A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.
纯度 ≥ 95 % by HPLC
Chemical Name 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide
Formula C₂₀H₂₂ClN₃O₃
Permeability Cell-permeable
Solubility DMSO (~ 180 mg/ml)
分子量 387.86 g/mol
CAS-编号 1032229-33-6
研究领域 Kinases/Phosphatases
限制 仅限研究用
状态 Solid
注意事项 Protect from air and light
储存条件 -20 °C
有效期 24 months
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有引用在: Iwasaki, Suganami, Hachiya, Shirakawa, Kim-Saijo, Tanaka, Hamaguchi, Takai-Igarashi, Nakai, Miyamoto, Ogawa: "Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages." in: Diabetes, Vol. 63, Issue 1, pp. 152-61, 2013 (PubMed).