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ATM Kinase Inhibitor, KU-55933

ABIN412287 产品详细信息, 供应商: Log in to see
应用范围
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 An ATM kinase inhibitor
产品特性 A potent, selective and ATP-competitive inhibitor of Atm Kinase (Ki = 2.2 nM, IC50 = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC50 = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
纯度 ≥ 97 % by HPLC
Chemical Name 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933
Formula C₂₁H₁₇NO₃S₂
Permeability Cell-permeable
Solubility DMSO (100 mM) and Ethanol (50 mM)
分子量 395.49 g/mol
CAS-编号 587871-26-9
限制 仅限研究用
状态 Solid
注意事项 Protect from air and light
储存条件 -20 °C
有效期 24 months
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 image for ATM Kinase Inhibitor, KU-55933 (ABIN412287) ATM Kinase Inhibitor, KU-55933
有引用在: DeLoughery, Luczak, Ortega-Atienza, Zhitkovich: "DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 54-63, 2014 (PubMed).