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Z-VDVAD-FMK

ABIN412074 产品详细信息, 供应商: Log in to see
应用范围
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A caspase-4 inhibitor
序列 Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
产品特性 A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
纯度 Single spot by TLC
Chemical Name Z-VDVAD-FMK, Z-VDVAD-fluoromethylketone, Caspase-2 Inhibitor (fluoromethylketone)
Formula C₃₂H₄₆FN₅O₁₁
Permeability Cell-permeable
Solubility DMSO (20 mM)
分子量 695.7 g/mol
应用备注 We recommend using 2-10 µM for inhibiting caspase activity in cell culture.
The optimal doses may vary for different cells and culture conditions.
限制 仅限研究用
状态 Solid, Lyophilized
注意事项 Protect from light and moisture
储存条件 -20 °C
有效期 12 months
厂商提供的图像
 image for Z-VDVAD-FMK (ABIN412074) Z-VDVAD-FMK
有引用在: Pianu, Lefort, Thuiliere, Tabourier, Bartolini: "The Aβ₁₋₄₂ peptide regulates microtubule stability independently of tau." in: Journal of cell science, Vol. 127, Issue Pt 5, pp. 1117-27, 2014 (PubMed).

Chang, Lin, Wu, Kuo, Wu, Shieh, Gean, Chen, Chen, Wu, Tai, Tseng: "Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 7, pp. 4214-22, 2011 (PubMed).

Ariazi, Cunliffe, Lewis-Wambi, Slifker, Willis, Ramos, Tapia, Kim, Yerrum, Sharma, Nicolas, Balagurunathan, Ross, Jordan: "Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 47, pp. 18879-86, 2011 (PubMed).

Höglund, Nilsson, Forshell, Maclean, Nilsson: "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine." in: Blood, Vol. 113, Issue 18, pp. 4281-8, 2009 (PubMed).

Nakajima, Nishimura, Nakaima, Oh, Noguchi, Taniguchi, Tamura: "Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 30, pp. 12448-52, 2009 (PubMed).

Upton, Austgen, Nishino, Coakley, Hagen, Han, Papa, Oakes: "Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 3943-51, 2008 (PubMed).