Caspase-13 Inhibitor LEED-FMK

ABIN412051 产品详细信息, 供应商: Log in to see
应用范围
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
原理 A caspase-13 inhibitor
序列 Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK
产品特性 PubChem CID: 44135223
A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
纯度 > 95 % by HPLC
Chemical Name Z-LEED-FMK, Z-LEED-fluoromethylketone, Caspase-13 Inhibitor (fluoromethylketone)
Formula C₃₂H₄₅FN₄O₁₂
Permeability Cell-permeable
Solubility In DMSO (10 mM)
分子量 696.7 g/mol
应用备注 We recommend using 1000-5000X dilutions for inhibiting caspase-13 and related caspase activity (e.g., Add 1 µL to 1-5 mL of culture medium). The optimal doses may vary among different cells and culture conditions. The inhibitor is designed as a methyl ester to facilitate cell permeability.
限制 仅限研究用
状态 Liquid
浓度 10 mM
注意事项 Protect from light and moisture
储存条件 -20 °C
有效期 12 months
有引用在: Bian, Sun, Silver, Ho, Marchionni, Caggiano, Stone, Amende, Hampton, Morgan, Yan: "Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins." in: American journal of physiology. Heart and circulatory physiology, Vol. 297, Issue 6, pp. H1974-83, 2009 (PubMed).