NEW: 请通过本地经销商订购 4A Biotech Co.,Ltd.

Necrosis Inhibitor, Necrox-5

ABIN1685483 产品详细信息, 供应商: Log in to see
应用范围
Blocking Reagent (BR), Inhibition Assay (InhA)
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

原理 A necrosis inhibitor
产品特性 A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1 µM NecroX-5 prevented ca. 50 % cell death in H9C2 cells exposed to 400 µM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.
纯度 ≥ 95 % by HPLC
Chemical Name [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, dihydrochloride
Formula C₂₅H₃₁N₃O₃S₂ ∙ 2CH₄O₃S
Permeability Cell-permeable
Solubility DMSO (> 10 mg/mL) or H2O (> 10 mg/mL)
分子量 645.83 g/mol
CAS-编号 1383718-29-3
限制 仅限研究用
状态 Solid
注意事项 Protect from light and moisture
储存条件 -20 °C
有效期 24 months
厂商提供的图像
 image for Necrosis Inhibitor, Necrox-5 (ABIN1685483) Necrosis Inhibitor, Necrox-5
有引用在: Wang, Xiao, Ling, Meng, Wu, Yang, Zou: "BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 140, Issue 2, pp. 393-402, 2014 (PubMed).