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抗Human Endothelin 1 抗体:
抗Mouse (Murine) Endothelin 1 抗体:
抗Rat (Rattus) Endothelin 1 抗体:
Human Monoclonal Endothelin 1 Primary Antibody for IP, ELISA - ABIN560688
Ghoul, Serova, Astorgues-Xerri, Bieche, Bousquet, Varna, Vidaud, Phillips, Weill, Benhadji, Lokiec, Cvitkovic, Faivre, Raymond: Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. in Cancer research 2009
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Cow (Bovine) Polyclonal Endothelin 1 Primary Antibody for IHC, ELISA - ABIN1582246
Jo, Ryu, Kim, Yeo, Kim, Choi, Song, Kang: Up-regulation of endothelial endothelin-1 expression prior to vasogenic edema formation in the rat piriform cortex following status epilepticus. in Neuroscience letters 2011
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Dog (Canine) Monoclonal Endothelin 1 Primary Antibody for ICC, FACS - ABIN152685
Talati, West, Blackwell, Loyd, Meyrick: BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. in American journal of physiology. Lung cellular and molecular physiology 2010
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Cow (Bovine) Polyclonal Endothelin 1 Primary Antibody for IHC, ELISA - ABIN1582247
Hayashi, Hosoe, Takahashi: Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy. in Animal reproduction science 2012
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Human Monoclonal Endothelin 1 Primary Antibody for IHC (fro), IRMA - ABIN2473438
Papalambros, Sigala, Georgopoulos, Menekakos, Giatromanolaki, Bastounis, Sivridis: Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter. in International journal of molecular medicine 2003
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB (显示 ALMS1 抗体) disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (显示 ACE 抗体).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (显示 EDNRA 抗体)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (显示 NFKB1 抗体) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (显示 CA2 抗体)+ transients in atrial myocytes through Ins (显示 INS 抗体)(1,4,5)P3-dependent Ca2 (显示 CA2 抗体)+ release from perinuclear Ca2 (显示 CA2 抗体)+ stores
The enhancement of gap junction intercellular communication is activated by endothelin-1 via modulating the expression of connexin43 (显示 GJA1 抗体), and plays an important role in the pathogenesis of cerebral vasospasm
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (显示 MAPK14 抗体) kinase-mediated production of superoxide from NADPH oxidase (显示 NOX1 抗体) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (显示 HEBP1 抗体) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (显示 EDNRA 抗体)) receptors coupled to extracellular Ca(2 (显示 CA2 抗体)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6 (显示 IL6 抗体), endothelin ET-1, and apoptotic Bak (显示 BAK1 抗体) and Bcl-XL (显示 BCL2L1 抗体) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (显示 SRC 抗体) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (显示 ECE1 抗体)) acting via endothelin receptor A (显示 EDNRA 抗体) in the control of luteolytic sensitivity in the pig
Data indicate that patients with systemic sclerosis (SSc (显示 CYP11A1 抗体)) displayed higher serum levels of VEGF (显示 VEGFA 抗体), endothelin-1 and s-Fractalkine (显示 CX3CL1 抗体), and that the s-Fractalkine (显示 CX3CL1 抗体) levels positively correlated with CD34 (显示 CD34 抗体)(+)CD45 (显示 PTPRC 抗体)(-) endothelial progenitor cells (EPC (显示 TCF21 抗体)) numbers.
Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention
we could provide evidence that established stress-related biomarkers ET-1, MCP-1 (显示 CCL2 抗体), CGA (显示 CGA 抗体) were differentially regulated among patients with AF compared to healthy controls.
Two END1 (显示 VPS11 抗体) polymorphisms do not appear to affect the development of hypertension in the Chinese population.
TWEAK (显示 TNFSF12 抗体) may stimulate endothelial ET-1 synthesis, through the up-regulation of ECE-1 (显示 ECE1 抗体).
ET-1 may be a unique predictor of heart failure prognosis
The EDNRA (显示 EDNRA 抗体) SNP rs5335 was independently associated with aneurysms >/=7 mm in size at the time of rupture. Patients with cerebral aneurysms also carrying the G allele of EDNRA (显示 EDNRA 抗体) SNP rs5335 may develop larger aneurysms before rupture.
c-Src tyrosine kinase (显示 CSK 抗体) mediates high glucose-induced endothelin-1 expression
Endothelin contributes to the rise in SBP (显示 SHBG 抗体) in response to acute hypoxia in patients with severely untreated OSA.
Results show a correlation between ET-1 and an impaired liver function, quantified by the maximal liver function capacity test, in critically ill patients. The findings approve the close interaction between TNF-alpha (显示 TNF 抗体) and ET-1 in sepsis.
SIX1 (显示 SIX1 抗体) regulates dorsal arch development not only by inducing dorsal Jag1 (显示 JAG1 抗体) expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (显示 EDNRA 抗体) signaling.
NOX4 (显示 NOX4 抗体)-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 production.
in normal tissues the tandem of serine carboxypeptidases, Scpep1 (显示 SCPEP1 抗体) and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
Newborn endothelial cells express high levels of ET-1 peptides, rapidly release ET-1 in response to endothelial stimulation, and initiate ET-1-mediated endothelium-dependent constriction
cellular and molecular mechanisms of ET-1 action in periodontitis
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 via upregulation of the ETB (显示 EDNRB 抗体) receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
reduced lung levels of PPARgamma (显示 PPARG 抗体) and increased levels of microRNA-27a (miR (显示 MLXIP 抗体)-27a), v-ets (显示 ETS1 抗体) avian erythroblastosis virus E26 oncogene (显示 RAB1A 抗体) homolog 1 (ETS1 (显示 ETS1 抗体)), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (显示 PECAM1 抗体) and E selectin (显示 SELE 抗体)).
Increased circulating Edn1 and expression of Ednra (显示 EDNRA 抗体) in endothelial cells are characteristic of diabetic kidney disease-susceptible mice.
Phylogenetic analysis of conserved grhl (显示 GHRL 抗体)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (显示 GRHL3 抗体) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (显示 EDNRA 抗体) (endothelin-1/endothelin-1 receptor type A (显示 EDNRA 抗体)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (显示 DNAH8 抗体) in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (显示 EDNRA 抗体) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2 (显示 EDN2 抗体), EDN3 (显示 EDN3 抗体)) and EDN (显示 RNASE2 抗体)-converting enzymes (ECE1 (显示 ECE1 抗体), ECE2 (显示 ECE2 抗体)) are expressed in epithelial cells; EDN (显示 RNASE2 抗体) receptors (EDNRA (显示 EDNRA 抗体), EDNRB (显示 EDNRB 抗体)) are present in smooth-muscle. Expression of EDN1, EDN2 (显示 EDN2 抗体), and ECE2 (显示 ECE2 抗体) is highest on day of ovulation. EDN (显示 RNASE2 抗体)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (显示 NOX1 抗体)-PKCalpha (显示 PKCa 抗体)-p(38)MAPK (显示 MAPK1 抗体) and NFkappaB-MT1MMP (显示 MMP14 抗体) signaling pathways along with a marked decrease in TIMP-2 (显示 TIMP2 抗体) expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (显示 PLA2G4A 抗体) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS (显示 NOS 抗体) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (显示 OLR1 抗体) and CD40 (显示 CD40 抗体) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (显示 EDNRB 抗体) during the peri (显示 PLIN1 抗体)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, gene for endothelin
, endothelin 1
, preproendothelin 1
, endothelin 1 L homeolog