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抗Human Stanniocalcin 1 抗体:
抗Mouse (Murine) Stanniocalcin 1 抗体:
抗Rat (Rattus) Stanniocalcin 1 抗体:
Human Monoclonal Stanniocalcin 1 Primary Antibody for ELISA, WB - ABIN563043
dos Santos, Trindade, Gonçalves, Bressan, Anastassopoulos, Yunes, Kobarg: Human stanniocalcin-1 interacts with nuclear and cytoplasmic proteins and acts as a SUMO E3 ligase. in Molecular bioSystems 2010
Human Polyclonal Stanniocalcin 1 Primary Antibody for IHC (p), WB - ABIN4892215
Hayase, Sasaki, Matsubara, Seo, Miyakoshi, Murata, Ozaki, Kakudo, Kumamoto, Ylaya, Cheng, Thorgeirsson, Hewitt, Ward, Kimura: Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells. in Thyroid : official journal of the American Thyroid Association 2015
Cow (Bovine) Polyclonal Stanniocalcin 1 Primary Antibody for WB - ABIN2777144
Gao, Xu, Chen, Wang, Wang, Wu, Yuan: Potential protein toxicity of synthetic pigments: binding of poncean S to human serum albumin. in Biophysical journal 2008
Show all 2 Pubmed References
Stanniocalcin 1 downregulation is responsible for sorafenib-induced cardiotoxicity through activated ROS (显示 ROS1 抗体) generation.
the results suggest that the CaSR is critical for Ca(2+) homeostasis in larval zebrafish exposed to low environmental Ca(2+) levels, possibly owing to its modulation of stanniocalcin mRNA expression.
This study showed that stanniocalcin 1 (stc1)modulates cation levels in trpm7 (显示 TRPM7 抗体) mutants and in the wild type; levels of cations are restored to normal in trpm7 (显示 TRPM7 抗体) mutants when stc1 activity is blocked.
STC-1 negatively regulates epithelial Ca(2 (显示 CA2 抗体)+) channel gene expression to reduce Ca(2 (显示 CA2 抗体)+) uptake in zebrafish embryos
Our results demonstrated the contrasting effects of STC1 and STC2 (显示 STC2 抗体)-derived peptides on human macrophage foam cell formation associated with ACAT1 (显示 ACAT1 抗体) expression and on HASMC migration.
Ssecretory STC1 enhances metastatic potential of hepatocellular carcinomas via JNK (显示 MAPK8 抗体) signaling.
Glycolysis from glucose is regulated by hSTC-1, decreasing the adequate supply of glycerol-3-phosphate (G3P) needed for fatty acid esterification and triacylglycerol (TG) storage in brown adipose tissue (BAT (显示 BAAT 抗体)). The decrease of TG capacity synthesis from glucose by hSTC-1 compromises the BAT (显示 BAAT 抗体) thermogenic capacity.
Increased STC1 plasma level represents a hallmark of late-onset preeclampsia; STC1 gene variants modulate placental gene expression and maternal hormone levels.
Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties.
Study demonstrates that STC1 is overexpressed in the prostate carcinoma cell lines and suggests that it promotes prostate carcinoma cell proliferation via cyclin E1 (显示 CCNE1 抗体)/CDK2 (显示 CDK2 抗体).
In the fed state, STC1 increases the incorporation of (14)C from glucose into lipids in the white retroperitoneal adipose tissue (WRAT). STC1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.
STC1 protein is significantly up-regulated in midsecretory endometrial fluid and is dysregulated in eutopic endometrial tissue from women with endometriosis. It is likely regulated by cAMP and may be involved in the pathogenesis of decidualization defects.
STC1 expression is significantly upregulated in human masticatory mucosa during wound healing
elevated STC-1 expression is associated with poor clinical outcome in triple-negative breast cancer (TNBC) patients, and STC-1 is directly involved in the invasiveness of TNBC cells
The temporal and cell type-specific expression of STC1 makes this gene a unique marker for implantation in pigs.
The effect of STC1 on the steroidogenetic pathway in cultured granulosa cells is reported.
Over-expression of STC-1 up-regulated Bcl-2 (显示 BCL2 抗体) protein expression and slightly down-regulated caspase-3 (显示 CASP3 抗体) production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
theca cell-derived big STC is targeted to the cholesterol/lipid storage droplets of luteal cells to regulate steroidogenesis.
once removed from their normal context within the ovary, luteal cells are capable of synthesizing and secreting big STC.
STC-1 in milk is increased following milk stasis
STC-1 maybe improve anti-inflammation, anti-oxidant and anti-apoptosis activities by affecting reactive oxygen species -mediated pathways, especially the phospho-modifications of the respective proteins, resulting in the increase of Superoxide dismutase (显示 SOD1 抗体) and reduce of capase-3, p53 (显示 TP53 抗体), IL-6 (显示 IL6 抗体) and IFN-gamma (显示 IFNG 抗体).
STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin (显示 F2 抗体)-induced signaling through PAR1 (显示 F2R 抗体) to ERK (显示 EPHB2 抗体), and inhibits bleomycin-induced pneumonitis.
Stanniocalcin 1 is expressed in thyroid side population cells and thyroid cancer cells.
Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using Stc1.
Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase (显示 PRKAA2 抗体)-dependent pathway.
STC1 is an endogenous stress protein that may counteract LPS (显示 TLR4 抗体)-induced lung injury by inhibiting the inflammatory cascade and inducing antioxidant and antiapoptotic mechanisms.
Remarkably, X-linked genes are not overexpressed in female Stc1(-/-) mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression.
Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury.
STC1 was not crucial for the development of ischemic tolerance triggered by hypoxic preconditioning, or for preserving blood-brain barrier integrity but may be involved in functional recovery after stroke.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.