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findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates
The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Results suggest that musclin has a strong relationship with insulin (显示 INS 蛋白) resistance in type 2 diabetes mellitus.
osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator
Foxo1 (显示 FOXO1 蛋白) downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin (显示 INS 蛋白)-mediated upregulation of this gene in muscle cells.
Ostn is a naturally occurring ligand of the NPR-C (显示 NPR3 蛋白) clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C (显示 NPR3 蛋白), thus locally elevating levels of C-type natriuretic peptide (显示 NPPC 蛋白).
Data show that musclin (Ostn) production is stimulated by Ca2 (显示 CA2 蛋白)+-dependent proto-oncogene (显示 RAB1A 蛋白) protein c (显示 PROC 蛋白)-Akt (Akt (显示 AKT1 蛋白)) phosphorylation.
findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes
Musclin expression level is tightly regulated by nutritional changes and its physiological role could be linked to glucose metabolism
we detected 2 SNPs, A85C and T335C, that were located on the 3rd exon and the 3 untranslated regions of the bovine Osteocrin gene, respectively, using 413 Qinchuan cattle DNA samples.
involved in regulation of bone formation and mineralization