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PRKAR1A 抗体

(Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013].
PRKAR1A 抗体  (AA 1-250) PRKAR1A 抗体  (AA 1-250) PRKAR1A 抗体 (AA 1-250) (ABIN3021148)

PRKAR1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

PRKAR1A 抗体  (N-Term) PRKAR1A 抗体  (N-Term) PRKAR1A 抗体 (N-Term) (ABIN6264423)

PRKAR1A 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

PRKAR1A 抗体  (N-Term) PRKAR1A 抗体  (N-Term) PRKAR1A 抗体 (N-Term) (ABIN544271)

PRKAR1A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

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PRKAR1A 抗体 by 适用

Find PRKAR1A 抗体 for a variety of species such as anti-Human PRKAR1A, anti-Rat PRKAR1A, anti-Mouse PRKAR1A. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular PRKAR1A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN3021148
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6264423
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
  • (2)
Cat. No. ABIN544271
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IHC (p)
Validations
  • (4)
Cat. No. ABIN5518788
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (9)
  • (3)
Cat. No. ABIN2729578
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7185424
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (2)
Cat. No. ABIN7127774
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN519180
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7184468
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN562373
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN519181
Quantity 100 μg
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6745561
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (4)
  • (1)
Cat. No. ABIN1944928
Quantity 100 μg
Datasheet Datasheet
Reactivity Chicken, Cow, Human, Mouse, Pig, Rat, Sheep
Application WB, IF, IC
Validations
  • (2)
Cat. No. ABIN7296678
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN360569
Quantity 0.4 mL
Datasheet Datasheet

Latest Publications for our PRKAR1A 抗体

Graham, Lackner, Terracciano, González-Cantú, Maleszewski, Greipp, Simon, Torbenson: "Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion." in: Hepatology (Baltimore, Md.), Vol. 68, Issue 4, pp. 1441-1447, (2019) (PubMed).

Graham, Terracciano, Meves, Vanderboom, Dasari, Yeh, Torbenson, Cruise: "Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 29, Issue 6, pp. 607-15, (2018) (PubMed).

Cao, Xia, Zhou, Yang, Hao, Peng, Liu, Zhu: "Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex." in: Scientific reports, Vol. 6, pp. 33557, (2016) (PubMed).

Sousa, Gomez, Diniz, Bernardes, Soares, Brito, Liu, Pontes, Stratakis, Gomes: "Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors." in: Endocrine-related cancer, Vol. 22, Issue 3, pp. 399-408, (2015) (PubMed).

Maleszewski, Larsen, Kip, Castonguay, Edwards, Carney, Kipp: "PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors." in: The American journal of surgical pathology, Vol. 38, Issue 8, pp. 1079-87, (2014) (PubMed).

Wells, OReilly, Szul, Sullivan, Handley, Garrett, McNicholas, Roda, Miller, Tal-Singer, Gaggar, Rennard, Jackson, Blalock: "An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 190, Issue 1, pp. 51-61, (2014) (PubMed).

Shajahan-Haq, Cook, Schwartz-Roberts, Eltayeb, Demas, Warri, Facey, Hilakivi-Clarke, Clarke: "MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer." in: Molecular cancer, Vol. 13, pp. 239, (2014) (PubMed).

Zhao, Li, Wohlford-Lenane, Agnihothram, Fett, Zhao, Gale, Baric, Enjuanes, Gallagher, McCray, Perlman: "Rapid generation of a mouse model for Middle East respiratory syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 13, pp. 4970-5, (2014) (PubMed).

Tian, Jiang, Tamosiuniene, Sung, Qian, Dhillon, Gera, Farkas, Rabinovitch, Zamanian, Inayathullah, Fridlib, Rajadas, Peters-Golden, Voelkel, Nicolls: "Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension." in: Science translational medicine, Vol. 5, Issue 200, pp. 200ra117, (2013) (PubMed).

Wang, Henry, Distefano, Wang, Räikkönen, Mönkkönen, Tanaka, Morita: "Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human V?2V?2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 3, pp. 1029-42, (2013) (PubMed).

Aliases for PRKAR1A 抗体

protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) 抗体
protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a) 抗体
protein kinase cAMP-dependent type 1 regulatory subunit alpha (Prkar1a) 抗体
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (prkar1aa) 抗体
cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene (LOC707275) 抗体
protein kinase cAMP-dependent type I regulatory subunit alpha (Prkar1a) 抗体
protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog (prkar1a.S) 抗体
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