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anti-Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) 抗体产品概述

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anti-Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) 抗体 (PRKAR1A)
在www.antibodies-online.cn可供52 Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) 抗体的13不同的供货商。 再加上,我们可以发Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) 蛋白 (18)和数多这个蛋白质的别的产品。 总共78 Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1)产品已列进来了。
别名:
1300018C22Rik, ACRDYS1, ADOHR, CAR, CNC, CNC1, im:7047729, PKR1, PPNAD1, PRKAR1, prkar1a, RIalpha, RIIA, Tse-1, TSE1, zgc:92515

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引用最多的anti-Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) 抗体

  1. Human Polyclonal PRKAR1A Primary Antibody for EIA, IHC (p) - ABIN360569 : Grönholm, Vossebein, Carlson, Kuja-Panula, Teesalu, Alfthan, Vaheri, Rauvala, Herberg, Taskén, Carpén: Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN360569

  2. Human Monoclonal PRKAR1A Primary Antibody for IF, IHC - ABIN2452637 : Maleszewski, Larsen, Kip, Castonguay, Edwards, Carney, Kipp: PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors. in The American journal of surgical pathology 2014 (PubMed)
    Show all 2 references for ABIN2452637

  3. Human Polyclonal PRKAR1A Primary Antibody for WB - ABIN519180 : Uys, Ramburan, Loos, Kinnear, Korkie, Mouton, Riedemann, Moolman-Smook: Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. in BMC cell biology 2011 (PubMed)

更多抗Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1)的相互作用对抗体

Zebrafish Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) interaction partners

  1. Results demonstrate that PKA activity regulated by Mys is indispensable for negative regulation of the Hh signaling pathway in Hh-responsive cells.

Mouse (Murine) Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) interaction partners

  1. data demonstrate that haploinsufficiency for either one of the type-II regulatory subunits improved the bone phenotype of mice haploinsufficient for Prkar1a

  2. PRKAR1A gene and its locus are altered in mixed odontogenic tumors. Expression is decreased in a subset of tumors, and Prkar1a(+) (/) (-) mice do not show abnormalities, which indicates that additional genes play a role in this tumor's pathogenesis.

  3. Prkar1a activation enhances beta-catenin (显示 CTNNB1 抗体) transcriptional activity through nuclear localization to PML (显示 PML 抗体) bodies.

  4. Loss of Prkar1a can only promote tumorigenesis when Prkar1a-mediated apoptosis is somehow countered.

  5. Data show that mammary-specific loss of Prkar1a leads to elevated type-II PKA isozyme activation and this is sufficient to drive breast carcinogenesis.

  6. Results show that mouse Prkar1a and human PRKAR2A (显示 PRKAR2A 抗体) exhibited a dynamic spatio-temporal expression in tooth development, whereas neither human PRKAR1A nor mouse Prkar2a (显示 PRKAR2A 抗体) showed their expression in odontogenesis.

  7. Ablation of Prkar1a interferes with signaling pathways necessary for osteoblast differentiation.

  8. hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1 (显示 RPS6KA1 抗体), which via phosphorylation of NHE1 (显示 SLC9A1 抗体) induces cardiomyocyte apoptosis.

  9. Prkar1a was found to play a critical role in peripheral nerve development.

  10. Dysregulated protein kinase A activity in the amygdala-prefrontal cortex circuitry in Prkar1a(+/-) mice is associated with behavioral phenotype of anxiety and a bias for threat

Human Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) interaction partners

  1. Electrostatic interactions are mediators in the allosteric activation of protein kinase A RIalpha.

  2. the present study reported for the first time an intronic splice site mutation in the PRKAR1A gene of a Chinese family with Carney complex, which probably caused skin pigmentation observed in affected family members.

  3. This study reports a novel point mutation of the PRKAR1A gene in a patient with Carney complex who presented with significant osteoporosis and fractures.

  4. Letter/Case Report: novel PRKAR1A mutation resulting in a splicing variant in a case of Carney complex.

  5. P-Rex1 (显示 PREX1 抗体) contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism.

  6. In the absence of a PRKAR1A gene mutation, our Cushing's syndrome patients do not fit the criteria for Carney's complex

  7. Case Report: although there was no family history of any of the Carney complex features and no mutations in the PRKAR1A gene were found, findings lead to the diagnosis of sporadic Carney complex.

  8. this study evaluated the functional characteristics of PRKAR1A regulatory subunits carrying eight different mutations identified in patients with acrodysostosis and compared the results with those obtained for the two alternative mutations involved in the Carney complex

  9. PRKAR1A gene and its locus are altered in mixed odontogenic tumors. Expression is decreased in a subset of tumors, and Prkar1a(+) (/) (-) mice do not show abnormalities, which indicates that additional genes play a role in this tumor's pathogenesis.

  10. The truncated enzyme lacks the functional cyclic adenosine monophosphate (cAMP) binding domain at the C-terminus, causing PRKAR1A haploinsufficiency.

Pig (Porcine) Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) interaction partners

  1. ceramide activates plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate

Cow (Bovine) Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) interaction partners

  1. Data suggest PRKAR1A contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca (显示 PRKACA 抗体); conservation of structure does not necessarily imply conservation of dynamics.

  2. Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2 (显示 AKAP10 抗体).

  3. Data show that RSK1 (显示 RPS6KA1 抗体) regulates PKAc activity in a cAMP-independent manner, and PKARIalpha by associating with RSK1 (显示 RPS6KA1 抗体) regulates its activation and its biological functions.

  4. angle X-ray scattering studies indicate RIalpha, RIIalpha, and RIIbeta (显示 PRKAR2B 抗体) homodimers differ markedly in overall shape despite extensive sequence homology and similar molecular masses;cAMP binding does not cause large conformational changes(Prkar1a, Prkar2a (显示 PRKAR2A 抗体))

  5. the PKA RIalpha subunit dynamic C helix mediates isoform-specific domain reorganization upon C subunit binding

Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A) 抗原简介

Antigen Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Alternative names and synonyms associated with Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A)

  • protein kinase, cAMP-dependent, regulatory, type I, alpha (PRKAR1A) 抗体
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (prkar1aa) 抗体
  • similar to cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) (PRKAR1A) 抗体
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A) 抗体
  • protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a) 抗体
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (Prkar1a) 抗体
  • 1300018C22Rik 抗体
  • ACRDYS1 抗体
  • ADOHR 抗体
  • CAR 抗体
  • CNC 抗体
  • CNC1 抗体
  • im:7047729 抗体
  • PKR1 抗体
  • PPNAD1 抗体
  • PRKAR1 抗体
  • prkar1a 抗体
  • RIalpha 抗体
  • RIIA 抗体
  • Tse-1 抗体
  • TSE1 抗体
  • zgc:92515 抗体

Protein level used designations for PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) , cAMP-dependent protein kinase type I-alpha regulatory subunit , cAMP-dependent protein kinase regulatory subunit alpha 1 , cAMP-dependent protein kinase type I-alpha regulatory subunit-like , protein kinase, cAMP dependent regulatory, type 1, alpha , cAMP-dependent protein kinase regulatory subunit RIalpha , cAMP-dependent protein kinase type I-alpha regulatory chain , protein kinase A type 1a regulatory subunit , tissue-specific extinguisher 1 , protein kinase, cAMP dependent regulatory, type I, alpha , cAMP-dependent protein kinase type I regulatory subunit , cAMP-dependent protein kinase, regulatory subunit alpha 1

GENE ID SPECIES
454845 Pan troglodytes
480459 Canis lupus familiaris
494533 Danio rerio
707275 Macaca mulatta
719009 Macaca mulatta
100216463 Ovis aries
100395681 Callithrix jacchus
100588658 Nomascus leucogenys
19084 Mus musculus
5573 Homo sapiens
25725 Rattus norvegicus
397091 Sus scrofa
100171685 Pongo abelii
615074 Bos taurus
417438 Gallus gallus
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