HtrA Serine Peptidase 1 蛋白 (HTRA1)产品概述

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HtrA Serine Peptidase 1 蛋白 (HTRA1)
在www.antibodies-online.cn可供20 HtrA Serine Peptidase 1 (HTRA1) 蛋白的7不同的供货商。 再加上,我们可以发HtrA Serine Peptidase 1 抗体 (73)HtrA Serine Peptidase 1 试剂盒 (29)和数多这个蛋白质的别的产品。 总共127 HtrA Serine Peptidase 1产品已列进来了。
别名:
AI429470, ARMD7, CARASIL, HTRA, HTRA1, L56, MGC145723, ORF480, Prss11, RSPP11, Xhtra1, zgc:92029, zgc:172061
列出全部蛋白 基因 基因ID UniProt
HTRA1 5654 Q92743
HTRA1 56213 Q9R118
HTRA1 65164 Q9QZK5

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  1. Human HTRA1 Protein expressed in Escherichia coli (E. coli) - ABIN368668 : Frochaux, Hildebrand, Talke, Linscheid, Schlüter: Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. in PLoS ONE 2014 (PubMed)

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Zebrafish HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.

Rhesus Monkey HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.

  2. Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR of ARMS2 (显示 ARMS2 蛋白) to be associated with drusen.

  3. As in humans, one variant within LOC387715/ARMS2 (显示 ARMS2 蛋白) and one in HTRA1 were significantly associated with age-related macular degeneration.

Human HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD (显示 AMD1 蛋白)) pathogenesis.

  2. Variants in HTRA1 are not associated with age-related macular degeneration.

  3. Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers

  4. FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation

  5. correlation between TGFb1 (显示 TGFB1 蛋白) and pSmad2 as well as between HtrA1 and TGFb1 (显示 TGFB1 蛋白) and the very significant increase of Ki67 (显示 MKI67 蛋白) in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis.

  6. Two synonymous polymorphisms in exon 1 of the HTRA1 gene result in a protein with altered thermophoretic properties.

  7. significant increase of serum HtrA1 in early-onset pre-eclampsia

  8. a frameshift mutation in the HTRA1 gene detected in a CARASIL pedigree resulted in reduced HTRA1 protein and increased TGF-beta1 (显示 TGFB1 蛋白) expression, which may cause severe CARASIL and peripheral small arterial disease

  9. Human HTRA1 expression is enhanced by Age-related macular degeneration specific indel mutation in the promoter region of HTRA1 gene, and this enhanced HTRA1 may be concerned with induce retinal neovasucularization.

  10. Results does not conclusively support HTRA1 role as a tumor suppressor but suggest its possible prognostic role in many human tumors.

Mouse (Murine) HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. transfection of cells with a constitutively active rapamycin-resistant p70S6K (显示 RPS6KB1 蛋白) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.

  2. Increased expressions of Tgf-beta1 (显示 TGFB1 蛋白), p-Smad2 (显示 SMAD2 蛋白)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.

  3. In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (显示 TGFB1 蛋白) pathway activation.

  4. HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone

  5. The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (显示 AMD1 蛋白)

  6. the inhibitory effect of IFN-gamma (显示 IFNG 蛋白) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (显示 NCOA5 蛋白)) mouse models and in human RA synovial cells.

  7. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

  8. Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (显示 BMP2 蛋白)-induced Smad1 (显示 SMAD1 蛋白)/5/8, ERK1/2 and p38 (显示 CRK 蛋白) phosphorylation in pre-osteoblasts.

  9. This study offers new insights into the regulation of HTRA-1 expression via LPS (显示 TLR4 蛋白)/TLR-4 (显示 TLR4 蛋白) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.

  10. suggest a critical role for LRP1 (显示 LRP1 蛋白) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (显示 CTGF 蛋白) protein levels.

Xenopus laevis HtrA Serine Peptidase 1 (HTRA1) interaction partners

  1. The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.

蛋白简介HtrA Serine Peptidase 1 (HTRA1)

蛋白简介

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.

Alternative names and synonyms associated with HtrA Serine Peptidase 1 (HTRA1)

  • HtrA serine peptidase 1a (htra1a)
  • HtrA serine peptidase 1 (HTRA1)
  • HtrA serine peptidase 1b (htra1b)
  • HtrA serine peptidase 1 (htra1)
  • Serine protease HTRA1 (htra1)
  • HtrA serine peptidase 1 (Htra1)
  • serine protease (HTRA)
  • AI429470 蛋白
  • ARMD7 蛋白
  • CARASIL 蛋白
  • HTRA 蛋白
  • HTRA1 蛋白
  • L56 蛋白
  • MGC145723 蛋白
  • ORF480 蛋白
  • Prss11 蛋白
  • RSPP11 蛋白
  • Xhtra1 蛋白
  • zgc:92029 蛋白
  • zgc:172061 蛋白

Protein level used designations for HtrA Serine Peptidase 1 蛋白 (HTRA1)

HtrA serine peptidase 1 , high-temperature requirement A serine peptidase 1A , serine protease 11 , serine protease HTRA1A , high-temperature requirement A serine peptidase 1B , serine protease HTRA1B , high temperature required A1 , Serine protease HTRA1 , IGFBP5-protease , high-temperature requirement A serine peptidase 1 , protease, serine, 11 (IGF binding) , serine protease HTRA1 , insulin-like growth factor binding protein 5 protease , protease, serine, 11 (Igf binding) , IGF binding , protease, serine, 11 , protease serine 11 , High-temperature requirement A serine peptidase 1 , Serine protease 11

GENE ID SPECIES
431766 Danio rerio
450792 Pan troglodytes
565082 Danio rerio
705855 Macaca mulatta
780187 Xenopus (Silurana) tropicalis
100064570 Equus caballus
100196695 Salmo salar
100541363 Meleagris gallopavo
100564246 Anolis carolinensis
100583976 Nomascus leucogenys
5654 Homo sapiens
56213 Mus musculus
477852 Canis lupus familiaris
282326 Bos taurus
65164 Rattus norvegicus
496061 Xenopus laevis
100857572 Gallus gallus
100008705 Oryctolagus cuniculus
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