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Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 (显示 EWSR1 ELISA试剂盒) KO mice
LGN (显示 GPSM2 ELISA试剂盒) and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing.
stimulation of GPR17 (显示 GPR17 ELISA试剂盒) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (显示 MBP ELISA试剂盒) expression levels mainly by triggering the Galphai/o signaling pathway.
Gnai1 missense mutation is responsible of hyperpigmentation in mouse model.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure.
leucine can directly facilitate insulin (显示 INS ELISA试剂盒) signaling through a Galphai protein-dependent intracellular signaling pathway
Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.
Mice with mutations of Gnai1 or Gnai2 (显示 GNAI2 ELISA试剂盒) have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 (显示 GNAI3 ELISA试剂盒) and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (显示 GNAI2 ELISA试剂盒), and Galphai3 (显示 GNAI3 ELISA试剂盒), with no evidence for functional coupling to Galphagust.
testosterone rapidly increased whole-cell HCAEC SKCa and BKCa (显示 KCNMA1 ELISA试剂盒) currents via a surface androgen receptor (显示 AR ELISA试剂盒), Gi/o protein, and protein kinase A
These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.
CGRP (显示 S100A12 ELISA试剂盒) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (显示 GNAS ELISA试剂盒), Galphai, and Galphaq (显示 GNAQ ELISA试剂盒)/11 pathways.
biochemical and computational data indicate that the interactions between alpha5, alpha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (显示 RND2 ELISA试剂盒) (or GDP rebinding).
Data indicate that hydroxyurea (HU) induces SAR1 (显示 IQGAP1 ELISA试剂盒) protein expression, which in turn activates gamma-globin (显示 HBG1 ELISA试剂盒) expression, predominantly through the Gialpha/JNK (显示 MAPK8 ELISA试剂盒)/Jun (显示 JUN ELISA试剂盒) pathway.
Gi alpha subunit (显示 POLG ELISA试剂盒) was found to be a key modulator of GABAB-receptors signaling in analgesia.
AC5, by binding active Galphai1, interferes with G-protein deactivation and reassembly and thereby might sensitize its own regulation.
Data indicate that focal adhesion kinase (FAK) activation and cell migration require Src, Gi/Go, COX-2 and LOXs activities.
resistin (显示 RETN ELISA试剂盒) contributes to the pro-inflammatory state of SMC (显示 DYM ELISA试剂盒) by the up-regulation of CX3CL1 (显示 CX3CL1 ELISA试剂盒) and CX3CR1 (显示 CX3CR1 ELISA试剂盒) expression via a mechanism involving NF-kB, AP-1 (显示 FOSB ELISA试剂盒), and STAT1 (显示 STAT1 ELISA试剂盒)/3 transcription factors, (2) resistin (显示 RETN ELISA试剂盒) employs TLR4 (显示 TLR4 ELISA试剂盒) and Gi-protein signaling.
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 1
, guanine nucleotide-binding protein G(i) subunit alpha-1
, Gi1 protein alpha-subunit
, alpha-subunit of G-protein, type G-alpha-i-1
, guanine nucleotide-binding protein G(i), alpha-1 subunit
, Gi1 protein alpha subunit
, Gi-alpha-1 protein
, guanine nucleotide binding protein (G protein), alpha inhibiting 1
, Galpha i1a