You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-LCP2 (LCP2) 抗体产品概述

Full name:
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) 抗体 (LCP2)
在www.antibodies-online.cn可供153 Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) 抗体的22不同的供货商。 再加上,我们可以发LCP2 蛋白 (9)LCP2 试剂盒 (4)和数多这个蛋白质的别的产品。 总共175 LCP2产品已列进来了。
别名:
AI323664, BB161688, SLP-76, Slp76, twm

最受欢迎的抗anti-LCP2 (LCP2) 抗体

选择您的来源和应用

抗Mouse (Murine) LCP2 抗体:

抗Rat (Rattus) LCP2 抗体:

抗Human LCP2 抗体:

所有可销售的anti-LCP2 抗体

您会转到已过滤好的搜索

引用最多的anti-LCP2 抗体

  1. Human Monoclonal LCP2 Primary Antibody for IF, IP - ABIN968146 : Harder, Kuhn: Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies. in The Journal of cell biology 2000 (PubMed)
    Show all 5 references for ABIN968146

  2. Human Monoclonal LCP2 Primary Antibody for WB - ABIN967597 : Fang, Motto, Ross, Koretzky: Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. in Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)
    Show all 3 references for ABIN967597

  3. Human Monoclonal LCP2 Primary Antibody for FACS, CyTOF - ABIN2666114 : Motto, Ross, Wu, Hendricks-Taylor, Koretzky: Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. in The Journal of experimental medicine 1996 (PubMed)
    Show all 3 references for ABIN2666114

  4. Human Monoclonal LCP2 Primary Antibody for WB - ABIN967606 : Janssen, Zhang: Adaptor proteins in lymphocyte activation. in Current opinion in immunology 2003 (PubMed)
    Show all 3 references for ABIN967606

  5. Human Monoclonal LCP2 Primary Antibody for ICS - ABIN1177173 : Wu, Koretzky: The SLP-76 family of adapter proteins. in Seminars in immunology 2004 (PubMed)
    Show all 2 references for ABIN1177173

  6. Human Monoclonal LCP2 Primary Antibody for IP, WB - ABIN264523 : Jackman, Motto, Sun, Tanemoto, Turck, Peltz, Koretzky, Findell: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. in The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for ABIN264523

  7. Human Monoclonal LCP2 Primary Antibody for IHC (p), IHC - ABIN269168 : Lin, Liu, Moore, Elizer, Veach, Hawiger, Ruley: Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)

  8. Human Polyclonal LCP2 Primary Antibody for IHC, ELISA - ABIN1532089 : Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012 (PubMed)

更多抗LCP2的相互作用对抗体

Mouse (Murine) Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. slp-76 contributes to the regulation of the tissue distribution, PLZF (显示 ZBTB16 抗体), and cytokine expression of iNKT cells via ADAP (显示 APP 抗体)-dependent and -independent mechanisms.

  2. findings identify ACK1 (显示 TNK2 抗体) as a novel SLP-76-associated protein-tyrosine kinase (显示 YES1 抗体) that modulates early activation events in T cells.

  3. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (显示 RANGAP1 抗体) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (显示 NFATC1 抗体) and NF-kappaB (显示 NFKB1 抗体) p65 (显示 NFkBP65 抗体) nuclear entry in T cells

  4. these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice

  5. Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees.

  6. this analysis identified 65 proteins not associated before with the Zap70 (显示 ZAP70 抗体)-Lat (显示 LAT 抗体)-SLP-76 network and thus should provide cues for future functional experiments.

  7. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1 (显示 PRAM1 抗体)/SKAP-HOM (显示 SKAP2 抗体) and SLP-76/Vav (显示 VAV1 抗体)/PLCgamma2 (显示 PLCG2 抗体) signaling hubs may be critical for Yersinia survival.

  8. analysis of a costimulatory mechanism by which CXCL12 (显示 CXCL12 抗体) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  9. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI (显示 FCER1A 抗体) and the IL-3 (显示 IL-3 抗体) receptor.

  10. These findings reveal a novel role for SLP-76 in CXCR4 (显示 CXCR4 抗体)-mediated T lymphocyte trafficking.

Human Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling.

  2. findings identify ACK1 (显示 TNK2 抗体) as a novel SLP-76-associated protein-tyrosine kinase (显示 EPHA8 抗体) that modulates early activation events in T cells.

  3. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  4. TSAD (显示 SH2D2A 抗体) binds to and co-localizes with Nck (显示 NCK1 抗体). Expression of TSAD (显示 SH2D2A 抗体) increases both Nck (显示 NCK1 抗体)-Lck (显示 LCK 抗体) and Nck (显示 NCK1 抗体)-SLP-76 interaction in T cells.

  5. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (显示 RANGAP1 抗体) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (显示 NFATC1 抗体) and NF-kappaB (显示 NFKB1 抗体) p65 (显示 GORASP1 抗体) nuclear entry in T cells

  6. SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling

  7. analysis of a costimulatory mechanism by which CXCL12 (显示 CXCL12 抗体) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  8. Multipoint binding of SLP-76 to ADAP (显示 FYB 抗体) facilitates the assembly of SLP-76 microclusters.

  9. Data indicate a role for the SAM (显示 TTN 抗体) domain in mediating SLP-76 self-association for T-cell function.

  10. Data indicate that the intracellular signaling of ITK (显示 ITK 抗体)-SYK (显示 SYK 抗体) requires both SLP-76 and the adapter function of SYK (显示 SYK 抗体)/ZAP-70 (显示 ZAP70 抗体) kinases.

LCP2 抗原简介

Antigen Summary

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Alternative names and synonyms associated with LCP2

  • lymphocyte cytosolic protein 2 (Lcp2) 抗体
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2) 抗体
  • AI323664 抗体
  • BB161688 抗体
  • SLP-76 抗体
  • Slp76 抗体
  • twm 抗体

Protein level used designations for LCP2

SH2 domain-containing leukocyte protein of 76 kDa , SLP-76 tyrosine phosphoprotein , lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD) , 76 kDa tyrosine phosphoprotein , SH2 domain-containing leukocyte protein of 76kD , lymphocyte cytosolic protein 2 , tyrosine phosphoprotein slp-76

GENE ID SPECIES
16822 Mus musculus
155918 Rattus norvegicus
3937 Homo sapiens
100511843 Sus scrofa
489126 Canis lupus familiaris
513244 Bos taurus
anti-LCP2 (LCP2) 抗体 精选生产商
您还需要查找其他产品吗?