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this study shows that mitochondrial reactive oxygen species suppress humoral immune responses through reduction of CD19 expression and resultant B cell receptor signaling in B cells
autoimmunity induced by excessive BAFF (显示 TNFSF13B ELISA试剂盒) production requires B1b B cells and CD19 signaling.
WIPF1 (显示 WIPF1 ELISA试剂盒) deficiency impaired CD19 co-receptor activation and subsequent PI3 kinase (显示 PIK3CA ELISA试剂盒) signaling, by distorting the actin and tetraspanin networks that lead to altered CD19 cell surface dynamics.
Syk (显示 SYK ELISA试剂盒)-deficient B cells require BAFF receptor (显示 TNFRSF13C ELISA试剂盒) and CD19/PI3K signaling for their long-term survival.
The selection of mature B cells is critically dependent on the expression level of the co-receptor CD19.
This inhibitory function of FcgammaRIIB in impairing the spatial-temporal colocalization of BCR (显示 BCR ELISA试剂盒) and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus
These results show that the ability of CD19-CAR T-cells to home in on tumor lesions is pivotal for their anti-tumor effects in our xenograft models, and therefore may enhance the efficacy of adoptive T-cell therapy for refractory B-cell lymphoma.
Data show that effective B cell receptor (BCR (显示 BCR ELISA试剂盒)) signaling requires collaboration with the coreceptor CD19 organized by the CD81 (显示 CD81 ELISA试剂盒)-tetraspanin network.
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
CD19positive CD45R (显示 PTPRC ELISA试剂盒)(lo)positive lymphocytes of embryonic origin are present in Peyer's patches and in the spleen throughout the life span of wild-type mice, beginning at postnatal day 7.
These data provide proof-of-principle for the view that newly generated Ab-secreting cells can acquire a mature plasma cell phenotype that is accompanied by loss of CD19 expression at an early stage of differentiation and that aging is not an obligate requirement for a CD19(neg) state to be established.
Results indicate the strong efficacy of FLAG-tagged CD19 CAR-T cells in solid and hematological cancer models.
The histological observations suggested that the patients represent diverse cases of NHL (显示 RTEL1 ELISA试剂盒) like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL (显示 RTEL1 ELISA试剂盒). The findings indicate that patients with NHL (显示 RTEL1 ELISA试剂盒) may also be analyzed for status of PAX5 (显示 PAX5 ELISA试剂盒), CD19 and ZAP70 (显示 ZAP70 ELISA试剂盒), and their transcriptional and post-translational variants for the differential diagnosis of NHL (显示 RTEL1 ELISA试剂盒) and therapy.
The frequencies of CD19+CD24hiCD38hi B-regulatory lymphocyte were significantly increased in children with beta-thalassemia.
a CD45 (显示 PTPRC ELISA试剂盒)+/CD19 - cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma.
CD19 is required for TLR9 (显示 TLR9 ELISA试剂盒)-induced B-cell activation (显示 BLNK ELISA试剂盒). Hence CD19/PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒)/BTK (显示 BTK ELISA试剂盒) is an essential axis integrating BCRs and TLR9 (显示 TLR9 ELISA试剂盒) signaling in human B cells.
High anti-EBV IgG levels in Crohn's disease are associated with 5-aminosalicylic acid treatment, tonsillectomy, and decrease of CD19(+) cells.
We propose that CD81 (显示 CD81 ELISA试剂盒) enables the maturation of CD19 and its trafficking to the membrane by regulating the exit of CD19 from the ER to the pre-Golgi compartment
we outline our approach to nonviral gene transfer using the Sleeping Beauty system and the selective propagation of CD19-specific CAR(+) T cells on AaPCs
We demonstrate that this motif plays a role in the maturation and recycling of CD19 but in a CD81 (显示 CD81 ELISA试剂盒)-independent manner.
DNA sequence analysis of the coding sequence of CD19, the CR2 co-signaling molecule.
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
spinster homolog 1 (Drosophila)
, CD19 antigen
, CD19 molecule
, b-lymphocyte antigen CD19-like
, B-lymphocyte antigen CD19
, differentiation antigen CD19
, B-lymphocyte surface antigen B4
, T-cell surface antigen Leu-12
, B cell surface marker CD19
, Differentiation antigen CD19