anti-大鼠 EIF2AK2 抗体 for ELISA

Recommended EIF2AK2 Antibody (supplied by: Log in to see )

抗原
Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) 抗体
  • PKR
  • pkr
  • EIF2AK2
  • DKFZp469K1934
  • EIF2AK1
  • PRKR
  • 2310047A08Rik
  • 4732414G15Rik
  • AI467567
  • AI747578
  • Pkr
  • Prkr
  • Tik
  • eukaryotic translation initiation factor 2 alpha kinase 2
  • eukaryotic translation initiation factor 2-alpha kinase 2
  • EIF2AK2
  • eif2ak2
  • Eif2ak2
抗原表位
C-Term
61
54
27
19
18
15
15
13
12
6
5
4
4
4
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
291
78
42
2
2
2
2
1
1
1
1
宿主

248
47
克隆类型
多克隆
标记
This EIF2AK2 antibody is un-conjugated
7
7
6
5
5
4
4
4
4
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
190
127
98
81
49
44
19
16
4
4
2
1
1
Supplier
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产品编号 ABIN1003006
$ 511.06
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1003007 IHC ELISA WB Rabbit IgG N-Term Log in to see Polyclonal 4
1 ABIN4345932 ELISA ICC IF IHC IHC (p) WB Rabbit all Isoforms Log in to see Polyclonal
1 ABIN4345931 ELISA IHC IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN1030589 IHC ELISA WB Rabbit C-Term Log in to see Polyclonal
1 ABIN1031517 IHC ELISA WB Rabbit N-Term Log in to see Polyclonal
1 ABIN2620304 ELISA WB Biotin Rabbit IgG AA 279-506 Log in to see Polyclonal
1 ABIN2620305 ELISA WB FITC Rabbit IgG AA 279-506 Log in to see Polyclonal
1 ABIN2620303 ELISA WB Rabbit IgG AA 279-506 Log in to see Polyclonal
1 ABIN1585063 IHC ELISA WB Rabbit Log in to see Polyclonal
1 ABIN1585062 IHC ELISA WB Rabbit Log in to see Polyclonal
1 ABIN2959690 IF IHC ELISA WB Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN2959691 IHC ELISA WB Rabbit IgG N-Term Log in to see Polyclonal
1 ABIN1887369 IHC ELISA WB Rabbit C-Term Log in to see Polyclonal
1 ABIN1888178 IHC ELISA WB Rabbit N-Term Log in to see Polyclonal
1 ABIN2432223 IHC ELISA Rabbit IgG Log in to see Polyclonal

General

抗原 Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) 抗体
抗原表位 C-Term
(61), (54), (27), (19), (18), (15), (15), (13), (12), (6), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 人, 小鼠, 大鼠
(291), (78), (42), (2), (2), (2), (2), (1), (1), (1), (1)
宿主
(248), (47)
克隆类型
多克隆
标记 This EIF2AK2 antibody is un-conjugated
(7), (7), (6), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
应用范围 Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(190), (127), (98), (81), (49), (44), (19), (16), (4), (4), (2), (1), (1)
Pubmed 4个引用可参考
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EIF2AK2抗体详情

EIF2AK2目标详情 使用细节 贮存及处理 References for anti-EIF2AK2 antibody (ABIN1003006) 图像
Blocking Peptide Blocking peptide for this product available: ABIN1003847
纯化方法 Affinity chromatography purified via peptide column.
免疫原 PKR antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PKR.
亚型 IgG

EIF2AK2目标详情

EIF2AK2抗体详情 使用细节 贮存及处理 References for anti-EIF2AK2 antibody (ABIN1003006) 图像 回页首
抗原
别名 PKR (Interferon Inducible RNA Dependent Protein Kinase) (EIF2AK2 Antibody 摘要)
背景 The interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
途径 ER-Nucleus Signaling, Hepatitis C

使用细节

EIF2AK2抗体详情 EIF2AK2目标详情 贮存及处理 References for anti-EIF2AK2 antibody (ABIN1003006) 图像 回页首
应用备注 This antibody can be used for detection of PKR by Western blot at 0.5 – 1 myg/ml. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far. This antibody is human, mouse and rat reactive.
限制 仅限研究用

贮存及处理

EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 References for anti-EIF2AK2 antibody (ABIN1003006) 图像 回页首
状态 Liquid
缓冲液 Antibody is supplied in PBS containing 0.02% sodium azide.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
储存条件 4 °C
有效期 12 months

References for anti-EIF2AK2 antibody (ABIN1003006)

EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 贮存及处理 图像 回页首
有引用在:

Gil, García, Esteban: "Caspase 9 activation by the dsRNA-dependent protein kinase, PKR: molecular mechanism and relevance." in: FEBS letters, Vol. 529, Issue 2-3, pp. 249-55, 2002

Saelens, Kalai, Vandenabeele: "Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation." in: The Journal of biological chemistry, Vol. 276, Issue 45, pp. 41620-8, 2001

Gil, Esteban: "Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action." in: Apoptosis : an international journal on programmed cell death, Vol. 5, Issue 2, pp. 107-14, 2001

Meurs, Chong, Galabru, Thomas, Kerr, Williams, Hovanessian: "Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon." in: Cell, Vol. 62, Issue 2, pp. 379-90, 1990