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p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis
Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans.
p58 (显示 CDK11B 蛋白)(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) pathway that requires activation of ATF6a (显示 ATF6 蛋白) and subsequently upregulates mitofusin 2 (显示 MFN2 蛋白).
interplay between p38 (显示 CRK 蛋白) phosphorylation and p58 (显示 CDK11B 蛋白)(IPK) upregulation has key roles in modulating ERp29 (显示 ERP29 蛋白)-induced cell-growth arrest and survival
the crystal structure of human P58 (显示 CDK11B 蛋白)(IPK)
Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP (显示 DDIT3 蛋白) and SREBP1 (显示 SREBF1 蛋白).
Spleen cells from transgenic mice overexpressing (Hu)PKR were studied and compared to those from wild-type mice after drug treatment. Dact-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division.
P58 (显示 CDK11B 蛋白)(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha (显示 EIF2A 蛋白) signaling, and thus attenuate the unfolded protein response.
The study demonstrates that P58 (显示 CDK11B 蛋白)(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells.
Cloning, prokaryotic expression of novel swine gene P58IPK and its polyclonal antibody preparation
Chaperone protein p58 (显示 CDK11B 蛋白)(IPK) is expressed predominantly in retinal ganglion cells (RGC), inner retinal neurons, and the photoreceptor inner segments.
combined deletion of ATF6alpha (显示 ATF6 蛋白) and the ER cochaperone p58 (显示 CDK11B 蛋白)(IPK) resulted in synthetic embryonic lethality.
Data present a working model for P58 (显示 CDK11B 蛋白)(IPK) to act together with Bip (显示 HSPA5 蛋白) to prevent protein aggregations and promote protein foldings within ER.
mechanism by which P58 (显示 CDK11B 蛋白)(IPK) functions to promote protein folding within the endoplasmic reticulum, determined from the crystal structure of P58 (显示 CDK11B 蛋白)(IPK)
renal injury inflicted by expression of the folding mutants was markedly enhanced by haploinsufficiency of the endoplasmic reticulum cochaperone p58 (显示 CDK11B 蛋白)(IPK).
The stress of unfolded proteins in the ER activates P58(IPK) transcription through an ER stress-response element in its promoter. P58(IPK) interacts with & inhibits PERK, which protects cells during the ER-stress response by reducing protein synthesis.
Insulin (显示 INS 蛋白) deficiency associated with the absence of P58 (显示 CDK11B 蛋白)(IPK) mimics beta-cell failure associated with type 1 and late-stage type 2 diabetes.
absence of P58 (显示 CDK11B 蛋白)(IPK) led to an increase in eIF2alpha (显示 EIF2A 蛋白) phosphorylation and decreased influenza virus mRNA translation
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).
dnaJ homolog subfamily C member 3
, endoplasmic reticulum DnaJ protein 6
, interferon-induced, double-stranded RNA-activated protein kinase inhibitor
, protein kinase inhibitor of 58 kDa
, protein kinase inhibitor p58
, protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
, DnaJ (Hsp40) homolog, subfamily C, member 3
, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor
, TPR repeat-containing protein
, DnaJ (Hsp40) homolog, subfamily C, member 3A
, DnaJ (Hsp40) homolog, subfamily C, member 3B
, protein kinase, interferon inducible double stranded RNA dependent inhibitor