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downregulation of REPS2 may contribute to malignant progression of esophageal squamous cell carcinoma and represent a novel prognostic marker and a potential therapeutic target for esophageal squamous cell carcinoma patients.
These results suggest that POB1 interacts with PAG2 through its proline-rich motif, thereby regulating cell migration.
POB1 (显示 TRIM37 蛋白), through its influence on the Ral (显示 rala 蛋白) signalling pathway, is involved in growth factor signalling and consequently in control of cell proliferation
decreased expression of REPS2 might be a key factor, causing prostate cancer cells to become resistant to induction of apoptosis by androgen deprivation.
Decreased REPS2 expression is associated with androgen-independent state of advanced prostate cancer
These results show for the first time that POB1 (显示 TRIM37 蛋白) can regulate the transport function of RLIP76 (显示 RALBP1 蛋白) and are consistent with our previous studies showing that inhibition of RLIP76 (显示 RALBP1 蛋白) induces apoptosis in cancer cells.
Hsf-1 (显示 HSF1 蛋白) causes specific and saturable inhibition of the transport activity of Ralbp1 (显示 RALBP1 蛋白) and that the combination of Hsf-1 (显示 HSF1 蛋白) and POB1 (显示 TRIM37 蛋白) causes nearly complete inhibition through specific bindings with Ralbp1 (显示 RALBP1 蛋白).
REPS2 may be a useful tumor marker for favorable prognosis in breast cancer.
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
RALBP1-interacting protein 2
, partner of Ral-binding protein 1
, partner of RalBP1
, ralBP1-associated Eps domain-containing protein 2
, RALBP1-associated Eps domain containing protein 2
, ralBP1-interacting protein 2