Use your antibodies-online credentials, if available.
Select your species
Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta (显示 GSK3b ELISA试剂盒)(Ser9) and Akt (显示 AKT1 ELISA试剂盒)(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (显示 AKT1 ELISA试剂盒)/GSK3beta (显示 GSK3b ELISA试剂盒) signaling axis at cilia in SHH (显示 SHH ELISA试剂盒)-dependent medulloblastoma that is regulated by INPP5E (显示 INPP5E ELISA试剂盒) to maintain tumor cell cilia, promote SHH (显示 SHH ELISA试剂盒) signaling and thereby medulloblastoma progression.
mTORC2 (显示 CRTC2 ELISA试剂盒) complex is responsible for phosphorylating Akt (显示 AKT1 ELISA试剂盒) at S(473).
FHL2 (显示 FHL2 ELISA试剂盒) facilitates ovarian granulosa cell tumor progression via controlling AKT1 (显示 AKT1 ELISA试剂盒) transcription.
Omentin (显示 ITLN1 ELISA试剂盒) protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt (显示 AKT1 ELISA试剂盒)/NOS3 (显示 NOS3 ELISA试剂盒)-dependent mechanism.
AIM2 (显示 AIM2 ELISA试剂盒) contributes to the maintenance of intestinal integrity via Akt (显示 AKT1 ELISA试剂盒) and protects against Salmonella mucosal infection.
Following transepithelial migration, neutrophils adhesion to ICAM-1 (显示 ICAM1 ELISA试剂盒) resulted in activation of Akt (显示 AKT1 ELISA试剂盒) and beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling, increased epithelial-cell proliferation, and wound healing.
Besides, both in vivo and in votro studies suggested that K145 stimulated insulin (显示 INS ELISA试剂盒) dependent Akt (显示 AKT1 ELISA试剂盒) phosphorylation and subsequently activates FoxO1 (显示 FOXO1 ELISA试剂盒) phosphorylation therefore inhibited gluconeogenetic genes expression including PEPCK (显示 PEPCK ELISA试剂盒) and G6pase (显示 G6PC ELISA试剂盒). Our study figures out a potential extent increase the value of developing K145 as therapeutic candidate for diabetes.
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (显示 AKT1 ELISA试剂盒) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (显示 AKT1 ELISA试剂盒) in heart.
High Akt1 (显示 AKT1 ELISA试剂盒) expression is associated with hepatocarcinogenesis.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (显示 CTNNB1 ELISA试剂盒) in the crosstalk between Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) and Wnt (显示 WNT2 ELISA试剂盒)/Ca(2 (显示 CA2 ELISA试剂盒)+) signaling pathways upon Wnt3a (显示 WNT3A ELISA试剂盒) stimulation in differentiating hNPCs.
STIM1 (显示 STIM1 ELISA试剂盒)-induced Ca(2 (显示 CA2 ELISA试剂盒)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (显示 PTPRB ELISA试剂盒) and VE-cadherin (显示 CDH5 ELISA试剂盒) and hence increase endothelial permeability.
Ascites and CCL18 (显示 CCL18 ELISA试剂盒) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin (显示 0 ELISA试剂盒), a process in part mediated through the PI3-kinase (显示 PIK3CA ELISA试剂盒)-Akt/PKB (显示 AKT1 ELISA试剂盒) cell survival pathway. These results provide further rationale for clinical investigation of relaxin (显示 0 ELISA试剂盒) as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (显示 EGFR ELISA试剂盒) and IL8 (显示 IL8 ELISA试剂盒) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Pyk2 is a key downstream signaling molecules of CCR7 (显示 CCR7 ELISA试剂盒) in SCCHN, which promotes SCCHN tumorigenesis and progression.
Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.
Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (显示 LPXN ELISA试剂盒).
Src (显示 SRC ELISA试剂盒) has a role in priming Pyk2 (but not FAK (显示 PTK2 ELISA试剂盒)) phosphorylation and subsequent activation downstream of integrins
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC protein kinase alpha RAC-PK alpha
, RAC-alpha serine/threonine-protein kinase
, murine thymoma viral (v-akt) oncogene homolog 1
, protein kinase B alpha
, thymoma viral proto-oncogene 1
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta