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hTau accumulation impairs synapse and memory by CaN-mediated suppression of nuclear CaMKIV/CREB (显示 CREB1 蛋白) signaling.
Within the pH range 5.0-11.5, CAMK4 maintained both its secondary and tertiary structures, along with its function, whereas significant aggregation was observed at acidic pH (2.0-4.5).
A positive association was not observed between rs10491334 in the CAMK4 gene and longevity in a Chinese population.
The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group.
Expression of CaMKIV inhibits autophosphorylation and activation of CaMKII (显示 CAMK2G 蛋白), and elicits G0/G1cell cycle arrest,impairing cell proliferation.
An imbalance of specific isoforms of CYFIP1 (显示 CYFIP1 蛋白), an FMRP (显示 FMR1 蛋白) interaction partner, and CAMK4, a transcriptional regulator of the FMRP (显示 FMR1 蛋白) gene, modulates risk for autism spectrum disorders.
CaMK4-dependent activation of AKT (显示 AKT1 蛋白)/mTOR (显示 FRAP1 蛋白) and CREM (显示 CREM 蛋白)-alpha underlies autoimmunity-associated Th17 imbalance.
CaMK4 regulates beta-cell proliferation and apoptosis in a CREB (显示 CREB1 蛋白)-dependent manner and CaMK4-induced IRS-2 (显示 IRS2 蛋白) expression is important in these processes
study suggests that the mutations in CAMK4 may lead to abnormal semen parameters
Phosphorylated Notch1 (显示 NOTCH1 蛋白)-IC by CaMKIV increases Notch1 (显示 NOTCH1 蛋白)-IC stability, which enhances osteoclast differentiation.
Pharmacological inhibition of CaMK4 recapitulated the observed defects in Cryptococcus neoformans phagocytosis. Furthermore, mice deficient in CaMK4 showed increased survival compared to wild-type mice upon infection with Cryptococcus neoformans. This increase in survival correlated with decreased expression of pattern recognition receptors on host phagocytes known to recognize Cryptococcus neoformans.
results imply that CaMKIV plays a role in maintenance the structure of chromatoid body by regulating the associations of proteins in it
CaMK4 activity is increased in T cells from systemic lupus erythematosus mice compared with the control group.
Results demonstrated that genetically inhibiting the CaMKK (显示 CAMKK2 蛋白) pathway via CaMKKbeta or CaMK IV is detrimental in the response of female mice to cerebral ischemia
CaMKIV-mTOR (显示 FRAP1 蛋白)-dependent autophagy is conserved in both immune and nonimmune/parenchymal cells and is fundamental for the respective functional and adaptive responses to septic insult.
The stimulation of CaMKII (显示 CAMK2G 蛋白) activity in the hippocampus is essential for rivastigmine-induced memory improvement in olfactory bulbectomized mice.
CaMKK (显示 CAMKK2 蛋白)/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia.
CaMKIV has opposing roles in nicotine and cocaine reward.
We identified the zebrafish homologue of CaMKIV (zCaMKIV) on the basis of biochemical characterization. zCaMKIV showed similar biochemical properties as well as tissue and subcellular distributions to rat CaMKIV (rCaMKIV)
Data suggest that Tyr (显示 TYR 蛋白)(99) phosphorylated calmodulin, as compared to non-phosphorylated, binds with a higher affinity at the calmodulin binding site (rich in basic amino acids) of CaM kinase IV leading to increased activation of CaM kinase IV.
conclude that the hypoxia-induced increased activation of CaM kinase IV cascade increases with the increase in the degree of cerebral tissue hypoxia as measured by cerebral tissue high energy phosphates in a curvilinear manner
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
calcium/calmodulin-dependent protein kinase type IV-like
, calcium/calmodulin-dependent protein kinase IV
, CAM kinase IV
, CAM kinase- GR
, brain Ca(2+)-calmodulin-dependent protein kinase type IV
, brain Ca++-calmodulin-dependent protein kinase type IV
, caM kinase-GR
, calcium/calmodulin-dependent protein kinase type IV
, calcium/calmodulin-dependent protein kinase type IV catalytic chain
, CAM kinase-GR
, Ca2+/calmodulin-dependent protein kinase type IV/Gr
, caMK IV
, Calmodulin-dependent protein kinase IV