anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) 抗体产品概述

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anti-Breast Cancer Anti-Estrogen Resistance 1 抗体 (BCAR1)
在www.antibodies-online.cn可供181 Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) 抗体的22不同的供货商。 再加上,我们可以发Breast Cancer Anti-Estrogen Resistance 1 试剂盒 (20)Breast Cancer Anti-Estrogen Resistance 1 蛋白 (7)和数多这个蛋白质的别的产品。 总共217 Breast Cancer Anti-Estrogen Resistance 1产品已列进来了。
别名:
AI385681, BCAR1, Cas, CAS1, CASS1, CRKAS, fc17f11, MGC68466, P130CAS, wu:fc17f11, zgc:175192

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  1. Chicken Monoclonal BCAR1 Primary Antibody for IHC (f), IF - ABIN967871 : Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for 967871

  2. Human Monoclonal BCAR1 Primary Antibody for WB - ABIN967617 : Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 967617

更多抗Breast Cancer Anti-Estrogen Resistance 1的相互作用对抗体

Xenopus laevis Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. bcar3 gene is expressed downstream of Gata2 (显示 GATA2 抗体) during gastrulation, and is co-expressed with gata2 (显示 GATA2 抗体) but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns

Human Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. the p130Cas FAT domain uniquely confers a mechanosensing function.

  2. Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 (显示 RBL2 抗体) Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness.

  3. Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs.

  4. Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer.

  5. blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin (显示 PXN 抗体) are significantly expressed in individual cases.

  6. expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness

  7. p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK (显示 PTK2 抗体) binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK (显示 PTK2 抗体) binding + greatly enhanced migration

  8. these data identify a new p130Cas/Cyclooxygenase-2 (显示 PTGS2 抗体) axis as a crucial element in the control of breast tumor plasticity.

  9. Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN (显示 PTEN 抗体), respectively.

  10. BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review)

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli (显示 TOMM22 抗体)-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.

  2. CRP2 (显示 CEBPB 抗体) sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.

  3. p130Cas plays pivotal roles in osteoclastic bone resorption.

  4. 31-kDa caspase (显示 CASP3 抗体)-generated cleavage product of p130Cas inhibited MyoD (显示 MYOD1 抗体)-induced transcriptional activation of muscle-specific (显示 EIF3K 抗体) genes.

  5. beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas (显示 CTNND1 抗体) signaling-adaptor proteins

  6. Crk-associated substrate -vinculin (显示 VCL 抗体) binding significantly affects the dynamics of Crk-associated substrate and vinculin (显示 VCL 抗体) within focal adhesions as well as the size of focal adhesions.

  7. we provide evidence that exercise-induced p38 MAPK (显示 MAPK14 抗体) signaling is not impaired by the muscle-specific (显示 EIF3K 抗体) deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.

  8. study described a molecular complex of PTPalpha (显示 PTPRA 抗体)-BCAR3 (显示 BCAR3 抗体)-Cas (显示 CTNND1 抗体)-Src (显示 SRC 抗体); this complex forms in response to PTPalpha (显示 PTPRA 抗体) Tyr789 phosphorylation and mediates Cas (显示 CTNND1 抗体) localization to focal adhesions and Cas (显示 CTNND1 抗体) downstream signaling to promote cell migration

  9. p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling

  10. Cas (显示 CTNND1 抗体) is required for apoptosis that is induced by proteasome inhibition, and potentially by other death stimuli.

Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) 抗原简介

Antigen Summary

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006

Alternative names and synonyms associated with Breast Cancer Anti-Estrogen Resistance 1 (BCAR1)

  • breast cancer anti-estrogen resistance 1 (bcar1) 抗体
  • breast cancer anti-estrogen resistance 1 (BCAR1) 抗体
  • breast cancer anti-estrogen resistance 1 (Bcar1) 抗体
  • breast cancer anti-estrogen resistance 1-like (LOC100350323) 抗体
  • AI385681 抗体
  • BCAR1 抗体
  • Cas 抗体
  • CAS1 抗体
  • CASS1 抗体
  • CRKAS 抗体
  • fc17f11 抗体
  • MGC68466 抗体
  • P130CAS 抗体
  • wu:fc17f11 抗体
  • zgc:175192 抗体

Protein level used designations for BCAR1

breast cancer anti-estrogen resistance 1 , breast cancer anti-estrogen resistance protein 1-like , Cas scaffolding protein family member 1 , Crk-associated substrate p130Cas , breast cancer anti-estrogen resistance protein 1 , CRK-associated substrate , p130 Cas , p130cas , v-crk-associated tyrosine kinase substrate

GENE ID SPECIES
398756 Xenopus laevis
415691 Gallus gallus
447979 Xenopus (Silurana) tropicalis
454246 Pan troglodytes
568309 Danio rerio
100391559 Callithrix jacchus
100435586 Pongo abelii
9564 Homo sapiens
12927 Mus musculus
25414 Rattus norvegicus
479648 Canis lupus familiaris
527550 Bos taurus
100127482 Sus scrofa
100350323 Oryctolagus cuniculus
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