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抗Human ARHGEF7 抗体:
抗Rat (Rattus) ARHGEF7 抗体:
抗Mouse (Murine) ARHGEF7 抗体:
Chicken Monoclonal ARHGEF7 Primary Antibody for IF, WB - ABIN968623
Bagrodia, Taylor, Jordon, Van Aelst, Cerione: A novel regulator of p21-activated kinases. in The Journal of biological chemistry 1998
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Rat (Rattus) Monoclonal ARHGEF7 Primary Antibody for IF, WB - ABIN968624
Manser, Loo, Koh, Zhao, Chen, Tan, Tan, Leung, Lim: PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. in Molecular cell 1998
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Human Polyclonal ARHGEF7 Primary Antibody for ICC, ELISA - ABIN1169227
Oh, Yoo, Jo, Song, Kim, Park: Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. in Biochemical and biophysical research communications 1997
each mutation in LRRK2 (显示 LRRK2 抗体) and ARHGEF7 demonstrated its unique functional property, which may contribute to the pathogenesis of Parkinson disease
we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease
Data show association of G protein-coupled receptor (显示 ADRA1A 抗体) kinase-interacting protein (显示 CIB1 抗体) 1 (GIT1), p21 (显示 CDKN1A 抗体)-activated kinase interacting exchange factor (betaPIX), and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1 (显示 PAK1 抗体)) with centrosomes.
Data show the role of Rho guanine nucleotide exchange factor 7 (beta-PIX) to the regulation of high mobility of lung adenocarcinoma cell line H1299 via regulation of focal adhesions dynamics, changes in actin cytoskeleton organization and cell polarity.
Phosphorylation of LRRK2 (显示 LRRK2 抗体) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7.
GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain.
Conversely, increased expression of betaPIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap (显示 YAP1 抗体)/Taz (显示 TAZ 抗体), promoting localization of Yap (显示 YAP1 抗体)/Taz (显示 TAZ 抗体) to the cytoplasm and inhibiting cell migration and proliferation.
Data indicate that suppression of c-Cbl (显示 CBL 抗体) protein by rho guanine nucleotide exchange factor 7 (Cool-1) may be critical for generation of at least a subset of glioblastoma (GBM).
The interaction of betaPix with srGAP1 (显示 SRGAP1 抗体) is critical for maintaining suppressive crosstalk between Cdc42 (显示 CDC42 抗体) and RhoA (显示 RHOA 抗体) during 3D collagen migration.
BetaPix phosphorylation at Ser (显示 SIGLEC1 抗体)-340 upregulates Nox1 (显示 NOX1 抗体) through Rac (显示 AKT1 抗体) activation.
It provides for the first time, to our knowledge, a possible mechanism for the concerted action of tyrosine kinases, GIT1/betaPIX proteins, and Ca(2 (显示 CA2 抗体)+) in the propagation of signals leading to the regulation of microtubule nucleation in activated mast cells.
beta-Pix controls the spatial localization of Rac1 activity to drive collective AVE migration at a critical stage in mouse development.
Therefore, we propose that PKCgamma (显示 PRKCG 抗体) positively modulates dopamine release through beta2PIX phosphorylation.
Glucose stimulates Cav-1 (显示 CAV1 抗体) and induces its dissociation from Cdc42 (显示 CDC42 抗体), to promote Cdc42 (显示 CDC42 抗体)-betaPix binding and Cdc42 (显示 CDC42 抗体) activation, and to trigger downstream signaling and ultimately sustain insulin (显示 INS 抗体) release.
a model by which SNX27 (显示 SNX27 抗体) regulates trafficking of beta-Pix to focal adhesions and thereby influences cell motility.
betaPix-b(L) induced pinocytosis through cooperative action of the CH and Dbl (显示 MCF2 抗体) homology (DH) domains, demonstrating the role of betaPix-b(L) in the regulation of membrane dynamics
Stat3 binds to betaPIX, a Rac1 activator,and regulates Rac1 activity to modulate the organization of actin cytoskeleton and directional migration
phosphorylation-dephosphorylation cycle of Cool-1 at Tyr (显示 TYR 抗体)-442 can serve as a key regulatory signal for focal complex assembly-disassembly, and consequently, for the migration and invasive activity of Src (显示 SRC 抗体)-transformed
P85 beta-PIX, located downstream of Rac1, is a key regulator for the activations of FAK (显示 PTK2 抗体) or p38 MAP kinase (显示 MAPK14 抗体) and plays a pivotal role in focal complex formation and cell motility.
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Rho guanine nucleotide exchange factor (GEF) 7
, Rho guanine nucleotide exchange factor 7
, rho guanine nucleotide exchange factor 7-like
, PAK-interacting exchange factor beta
, SH3 domain-containing proline-rich protein
, guanine nucleotide exchange factor 7
, rho guanine nucleotide exchange factor 7
, Pak interacting exchange factor
, Pak3 binding protein