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Human DDC ELISA Kit for Sandwich ELISA - ABIN422044
Jang, Park, Lee, Lee, Kim, Koh: 1,25-dyhydroxyvitamin D3 attenuates L-DOPA-induced neurotoxicity in neural stem cells. in Molecular neurobiology 2015
lowered expression of Atg6 (显示 BECN1 ELISA试剂盒) or Pi3K59F in Ddc-Gal4 (显示 LGALS4 ELISA试剂盒)-expressing neurons results in decreased longevity and associated age-dependent loss of locomotor ability. Inhibition of Atg6 (显示 BECN1 ELISA试剂盒) or Pi3K59F together with overexpression of the sole pro-survival Bcl-2 (显示 BCL2 ELISA试剂盒) Drosophila homolog Buffy in Ddc-Gal4 (显示 LGALS4 ELISA试剂盒)-expressing neurons resulted in further decrease in the survival
epidermal Ddc induction at pupariation is under the control of an extended genomic region that contains both positive and negative regulatory elements
Broad-Complex protein is required for Ddc activation at eclosion in Drosophila
evidence for a wound response pathway that senses aseptic breaks in the barrier epidermis of Drosophila embryos; a minimal 472-bp Ddc wound response enhancer requires a Grh (显示 GNRH1 ELISA试剂盒) protein binding site and the function of the grh (显示 GNRH1 ELISA试剂盒) gene
The Ddc locus exhibits a complicated pattern of variation apparently due to several evolutionary forces.
The involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria.
Combinatorial expression of tyrosine hydroxylase (TH (显示 TH ELISA试剂盒)), aromatic acid acid decarboxylase (AADC), and the brain-specific (显示 CALY ELISA试剂盒) isoform of the vesicular monoamine transporter (显示 Slc18a2 ELISA试剂盒), VMAT2 (显示 Slc18a2 ELISA试剂盒).
Loss of Ddc appears to result in similar phenotypes as that of ADCC deficiency, thus zebrafish could be a good model for investigating pathogenetic mechanisms of AADC deficiency in children.
We found that only the modified U1 snRNA (IVS-AAA (显示 AAAS ELISA试剂盒)) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro
The data show that endothelial AADC plays an important role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent regulation of nitric oxide generation.
Mash1 (显示 ASCL1 ELISA试剂盒) plays an important role in regulating the expression of AADC in type III cells in taste buds.
evidence for PKGIalpha-dependent phosphorylation and activation of neuronal AAAD (显示 AADAC ELISA试剂盒) in vitro, and introduce AAAD (显示 AADAC ELISA试剂盒) as a putative PKGIalpha substrate.
Data suggest a possible participation of aromatic L-amino acid decarboxylase (AADC) in the regulation of catecholamine biosynthesis in stellate ganglia of repeatedly stressed mice.
Results suggest that AADC expression begins at early stages of taste bud cell differentiation, and biogenic amines may act on taste bud differentiation of tongue epithelial cells, and further may regulate innervation of taste bud progenitor cells.
analysis of Ddc redefines the imprinted Grb10 (显示 GRB10 ELISA试剂盒) domain on mouse proximal chromosome 11 and identifies Ddc_exon1a as the first example of a heart-specific imprinted gene
the fact that renal DDC inversely correlated with renal sodium reabsorption suggest that renal and intestinal gender dimorphism in DDC could be related to sex-related differences in sodium balance observed between males and females
SNP rs10499695 located intronically in the gene DDC, (DOPA decarboxylase) is significantly associated with cognitive performance in diabetes 2.
Molecular characteristic and physiological role of DOPA-decarboxylase is reviewed.
We found that only the modified U1 snRNA (IVS-AAA (显示 APP ELISA试剂盒)) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro
The results of this study showed that Lack of Association Between Polymorphisms in Dopa decarboxylase Genes With Childhood
The data showed that L-DOPA decarboxylase constitutes a highly promising molecular marker for renal cell carcinoma.
gene study of 987 BPD cases and 1110 healthy controls found an association between BPD [ borderline personality disorder ]and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene
Results revealed the general picture of structural and/or functional effects of each DDC mutation linked to AADC deficiency mutations and help to guide therapeutic decision and prevent inappropriate use of treatment regiments.
A novel homozygous DDC variant in syndromic intellectual disability patients, c.1123C>T, resulting in p.Arg375Cys missense substitution.
Results indicate that miR (显示 MLXIP ELISA试剂盒)-145 has the ability to regulate DDC mRNA expression and potentially this occurs by recognizing its mRNA as a target.
Our results suggest that DDC may be a genetic modifier of the l-dopa response in Parkinson's disease
The unusual oxygen-consuming oxidative deamination reaction catalyzed by the pyridoxal 5'-phosphate (PLP (显示 PLP1 ELISA试剂盒)) enzyme DOPA decarboxylase (DDC) was here investigated.
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, L-aromatic dopa decarboxylase
, aromatic-L-amino acid decarboxylase
, aromatic amino acid decarboxylase
, L-Dopa decarboxylase
, aromatic L-amino acid decarboxylase
, DHPAA synthase
, alpha methyl dopa
, alpha-methotrexate deficient
, alpha-methyl dopa resistant
, dopa decarboxylase
, transcription unit No. 1
, 3,4-Dihydroxyphenylalanine decarboxylase
, dopamine decarboxylase
, transcription unit No. 3
, dopa decarboxylase (aromatic L-amino acid decarboxylase)
, Aromatic-L-amino-acid decarboxylase
, aromatic-L-amino-acid decarboxylase-like
, DOPA decarboxylase